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J Rheumatol:银屑病关节炎患者药理生物标志物与治疗反应和长期残疾的关联

2020-01-08 xiangting MedSci原创

检测ADA初治PsA患者的药物水平有助于确定12个月内的治疗反应/残疾。

这项研究旨在确定:(1)银屑病关节炎(PsA)患者的肿瘤坏死因子抑制剂(TNFi)药物水平/抗药抗体(ADAb)是否与治疗反应和残疾有关;(2)与TNFi药物水平相关的因素。

从一个全国性多中心前瞻队列中招募患者,并在12个月内收集纵向血清样本并进行28关节计数疾病活动性评分(DAS28/健康评估问卷(HAQ)测量。

12个月内,阿达木单抗(ADA)水平与ΔDAS28β0.05595CI 0.011-0.099; p=0.014)显著相关,与HAQ呈负相关(β–0.02295CI –0.043–0.00063)。与ADA药物水平显著相关的因素是ADAb水平和体重指数。

检测ADA初治PsA患者的药物水平有助于确定12个月内的治疗反应/残疾。

原始出处:

Meghna Jani. Association of Pharmacological Biomarkers with Treatment Response and Longterm Disability in Patients with Psoriatic Arthritis: Results from OUTPASS. J Rheumatol. December 2019.

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    2020-01-10 lmm397
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