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帕金森氏症胚胎细胞疗法重启

2015-05-28 宗华 中国科学报

帕金森　胚胎细胞疗法
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近日，一名患有帕金森氏症的50多岁男性接受了将胚胎脑细胞注射进其大脑的治疗。他是近20年来首位以这种方式进行治疗的患者，并且将在大约5年后恢复对其动作的完全控制。“治疗效果看上去还不错。”来自英国剑桥大学的Roger Barker介绍说。他正带领一个国际团队重启该治疗过程。28年前，这种疗法在瑞典首创，但在美国开展的两次试验中，病人接受注射后的最初两年里并未出现显著疗效。于是，该治疗过程被放弃，取

近日，一名患有帕金森氏症的50多岁男性接受了将胚胎脑细胞注射进其大脑的治疗。他是近20年来首位以这种方式进行治疗的患者，并且将在大约5年后恢复对其动作的完全控制。

“治疗效果看上去还不错。”来自英国剑桥大学的Roger Barker介绍说。他正带领一个国际团队重启该治疗过程。

28年前，这种疗法在瑞典首创，但在美国开展的两次试验中，病人接受注射后的最初两年里并未出现显著疗效。于是，该治疗过程被放弃，取而代之的是深度脑刺激治疗。

这些试验所忽略的是，胚胎细胞同接受注射者的大脑磨合并且很好地连接起来需要若干年的时间。很多瑞典和北美患者在接受移植超过3年后，其症状得到明显缓解。而这是在试验结束的很久之后。“在最好的情况下，接受这种治疗的患者几乎回到正常状态。”Barker表示。

由于早期试验错过了改善阶段，因此从上世纪90年代起就没有人再接受过胚胎脑细胞注射。不过，这名最近在剑桥艾登布鲁克斯医院接受治疗的男性并未获得彻底治疗，因为该研究团队只有足够治疗其半个大脑的细胞。

这种移植依赖于终止妊娠的女性所捐献的胚胎细胞，因此研究人员无法知道什么时候还能再获得细胞。该疗法需要利用来自至少3个胚胎的细胞治疗每个大脑半球，但由于缺少细胞，早先治疗上述同一个人的4次尝试均不得不被停止。

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    2015-05-31 huaxipanxing

    看看

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=25577, encodeId=c493255e7d6, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 31 21:15:00 CST 2015, time=2015-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1315251, encodeId=c9af1315251d4, content=<a href='/topic/show?id=6fcc83e0554' target=_blank style='color:#2F92EE;'>#胚胎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83705, encryptionId=6fcc83e0554, topicName=胚胎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6393434, createdName=ailian1202, createdTime=Sat May 30 02:57:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25196, encodeId=a2ee2519626, content=有谁能提供进一步的资料！我们一般用核团焚毁或者dbs, beContent=null, objectType=article, channel=null, level=null, likeNumber=204, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:16:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25195, encodeId=a1b82519536, content=我是神经外科的而且用各种方法治疗帕金森！这次真的学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:15:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25187, encodeId=f1082518ee4, content=这是个很好的方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=559f1626469, createdName=youxnc, createdTime=Thu May 28 15:26:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25185, encodeId=d0fa251857c, content=希望, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=Dr.LV, createdTime=Thu May 28 15:20:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
    2015-05-30 ailian1202

    #胚胎#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=25577, encodeId=c493255e7d6, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 31 21:15:00 CST 2015, time=2015-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1315251, encodeId=c9af1315251d4, content=<a href='/topic/show?id=6fcc83e0554' target=_blank style='color:#2F92EE;'>#胚胎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83705, encryptionId=6fcc83e0554, topicName=胚胎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6393434, createdName=ailian1202, createdTime=Sat May 30 02:57:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25196, encodeId=a2ee2519626, content=有谁能提供进一步的资料！我们一般用核团焚毁或者dbs, beContent=null, objectType=article, channel=null, level=null, likeNumber=204, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:16:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25195, encodeId=a1b82519536, content=我是神经外科的而且用各种方法治疗帕金森！这次真的学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:15:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25187, encodeId=f1082518ee4, content=这是个很好的方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=559f1626469, createdName=youxnc, createdTime=Thu May 28 15:26:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25185, encodeId=d0fa251857c, content=希望, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=Dr.LV, createdTime=Thu May 28 15:20:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
    2015-05-28 summer474cn

    有谁能提供进一步的资料！我们一般用核团焚毁或者dbs

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=25577, encodeId=c493255e7d6, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 31 21:15:00 CST 2015, time=2015-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1315251, encodeId=c9af1315251d4, content=<a href='/topic/show?id=6fcc83e0554' target=_blank style='color:#2F92EE;'>#胚胎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83705, encryptionId=6fcc83e0554, topicName=胚胎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6393434, createdName=ailian1202, createdTime=Sat May 30 02:57:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25196, encodeId=a2ee2519626, content=有谁能提供进一步的资料！我们一般用核团焚毁或者dbs, beContent=null, objectType=article, channel=null, level=null, likeNumber=204, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:16:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25195, encodeId=a1b82519536, content=我是神经外科的而且用各种方法治疗帕金森！这次真的学习了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:15:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25187, encodeId=f1082518ee4, content=这是个很好的方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=559f1626469, createdName=youxnc, createdTime=Thu May 28 15:26:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25185, encodeId=d0fa251857c, content=希望, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=Dr.LV, createdTime=Thu May 28 15:20:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
    2015-05-28 summer474cn

    我是神经外科的而且用各种方法治疗帕金森！这次真的学习了！

    0

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    2015-05-28 youxnc

    这是个很好的方法

    0

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    2015-05-28 Dr.LV

    希望

    0

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