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Eur Heart J:走路慢的中年人心血管疾病以及全因死亡风险更大

2017-09-02 朱爽爽 奇点网

近日,来自英国国立卫生研究所,莱斯特生物医学研究中心久坐行为与健康领域专家 Tom Yates 教授的团队在心血管疾病顶级期刊《欧洲心脏杂志》上发表的一项研究表明,走路慢的中年人全因死亡风险以及心血管疾病死亡风险是走路快的近两倍。而且,这一发现已经排除了性别,吸烟,BMI,饮食或观看电视时间等心血管疾病相关危险因素。


Tom Yates 教授

这几天,关于青岛“暴走团”占用机动车锻炼的事件在微博上吵的沸沸扬扬。有人认为他们占领机动车道锻炼是违法的,是倚老卖老。也有网友替他们喊冤,认为问题出在我国的社会资源不足。而抛开对错,小编在这里只想说,难道没有人发现这些经常暴走的大爷大妈们看起来精神状态很好么?

近日,来自英国国立卫生研究所,莱斯特生物医学研究中心久坐行为与健康领域专家 Tom Yates 教授的团队在心血管疾病顶级期刊《欧洲心脏杂志》上发表的一项研究表明,走路慢的中年人全因死亡风险以及心血管疾病死亡风险是走路快的近两倍。而且,这一发现已经排除了性别,吸烟,BMI,饮食或观看电视时间等心血管疾病相关危险因素。 大家都知道,心血管疾病是全球的头号死因。世界卫生组织 2012 年发布的数据显示,全球当年死于心血管疾病的总人数为 1750 万人,占全球死亡总人数的 31%。并且这一数据还在逐年增加。

而我国的情况也不容乐观。据统计,我国目前有心血管疾病患者 2.9 亿左右。也就是说平均每 5 个人中就有一个心血管疾病患者。同时,我国每年还有近 350 万人死于心血管疾病。因此,对于心血管疾病的早期筛查与防治很有必要。

此前,已有研究表明,加强机体的适应能力特别是心肺适应功能可以预防心血管疾病。同时,心肺适应功能也是预测全因死亡率以及心血管疾病死亡风险的重要标志。但是由于心肺适应功能需要特定的仪器测量,并不适合大规模推广。因此,找到更加简单方便的预测心血管疾病风险的标志非常必要。



早在 1999 年,《新英格兰医学杂志》上发表的一项研究就表明,走路的快慢与女性的冠心病死亡风险密切相关。随后,2002 年《柳叶刀》上也发表了一篇文章证明,走路快的男性冠心病的死亡风险也较低。此外,2013 年的时候,对于老年人群的系统研究同样发现,走路快的老年人,全因死亡风险显着降低。这意味着,走路的快慢也许可以作为一个简单的,独立的预测心血管疾病的标志。

由于上述实验在设计上存在一些问题。例如,有的实验样本量太小,而有的实验没有排除其他心血管疾病的风险因素,如年龄,吸烟,BMI 的干扰等等。所以,为了更准确的获取步行速度与心血管疾病的临床相关性,以及其对心血管疾病的影响程度。Yates 教授开始了本次实验。

首先,在 2006 年 -2010 年的时候,Yates 教授先后从英国生物库(UK Biobank)中找到了 502639 名愿意参与实验的中年人,去掉其中已经患有癌症,心血管疾病的人群,以及信息不全的的人群,最终有 420727 位中年人符合实验的标准。

Yates 教授收集了这些人的详细信息,包括 BMI、走路快慢(步行速度每小时低于 4.8 公里属于慢,4.8-6.4 公里属于正常,而大于 6.4 公里属于快)、吸烟状况、酒精使用、心肺功能等等。并且,在随后 6.3 年的随访期间,Yates 教授还收集了所有在此期间死亡人群的信息。



在对这些信息进行系统分析,同时使用 COX- 风险比例模型排除了吸烟,BMI,饮食习惯,每周观看电视时长等常见因素的干扰后。Yates 教授发现,走路快慢与心肺功能适应密切相关。并且无论男女,走路快的人心肺适应能力较强,而走的慢的人心肺适应能力较弱。不仅如此,Yates 教授随后还分析了走路快慢与心血管疾病死亡风险以及全因死亡风险之间的关系。

结果,Yates 教授惊奇的发现,总体而言,走路慢的人心血管疾病死亡风险或者全因死亡风险相对于走路快的人增加超过 70%。有趣地是,Yates 教授还发现,走路快慢对全因死亡的风险或者心血管疾病的死亡风险的影响与年龄以及性别无关,而和 BMI 指数密切相关。

简单地说,就是,在 BMI 值高的人群中(>24kg/m2),相对于走路快的人,走路慢的人全因死亡风险增加 30% 左右,心血管疾病死亡风险增加 80% 左右。而对于 BMI 值正常的人群(18.5-23.9),走路慢的人全因死亡风险增加 70% 左右,心脑血管疾病死亡风险增加 100% 左右。同样地,对于 BMI 值低的人群(<18.5),走路慢的人全因死亡风险以及心血管疾病死亡风险分别增加 100% 和 120%。表明,走路快慢与瘦子的健康关系更密切。



总的来说,Yates 教授发现,走路的快慢与全因死亡率以及心血管疾病死亡率密切相关,可以独立作为心血管疾病的风险预测标志。特别地,走路慢的瘦子死亡风险更高。而此前的研究也表明,通过规律的有氧运动,可以显着增强人们的心肺适应功能,降低心血管疾病风险。不仅如此,一些研究还表明,有氧运动还可以显着降低 2 型糖尿病高血压,高血脂等心血管疾病高危风险因素发病风险。所以,对于瘦子来说,适当运动更有必要。如果不想锻炼,走路快点可能也是很有用的。

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    2017-12-03 cqlidoudou
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objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Sat Sep 02 12:46:43 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-09-04 1e1263e3m20(暂无匿称)

    涨见识了.看来以后不能散步了

    0

  4. 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objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Sat Sep 02 12:46:43 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-09-03 zhaojie88
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  7. 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objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Sat Sep 02 12:46:43 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-09-03 slcumt
  8. 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  9. 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objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Sat Sep 02 12:46:43 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-09-03 131****1460

    学习了受益匪浅

    0

  10. 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    2017-09-02 186****0580(小山羊)

    学习了谢谢了

    0

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