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JAMA:丹麦神经系统疾病患者自杀死亡风险研究

2020-02-05 MedSci MedSci原创

1980-2016年间,丹麦神经系统疾病确诊患者的自杀死亡风险高于其他疾病,但绝对风险仍保持较低水平

近日研究人员考察了神经疾病患者与其他患者相比的自杀风险差异。

研究在丹麦开展,1980-2016年间,15岁以上的患者纳入本次研究,总计包含7300395人,其中1248252人患有头部损伤、中风、癫痫、多发性神经病、腓骨交界疾病、帕金森病、多发性硬化症、中枢神经系统感染、脑膜炎、脑炎、肌萎缩侧索硬化症、亨廷顿病、痴呆、智力残疾和其他脑疾病。研究的主要终点为自杀死亡率。

研究随访161935233个随访年,其中男性占49.1%,随访期间35483名患者死于自杀。自杀人群中,男性占77.4%,5141人(14.7%)诊断患者有神经系统疾病,其自杀率为每100000患者年44.0例,而其他疾病人群则为每100000患者年20.1例。神经系统疾病相比于其他疾病患者的自杀风险IRR为1.8,其中肌萎缩侧索硬化症或亨廷顿病患者IRR为4.9、多发性硬化为2.2、头部损伤为1.7、中风为1.3、癫痫为1.7。神经系统疾病确诊后1-3个月的患者IRR风险为3.1,10年以上为1.5。相比于其他疾病患者,痴呆患者的总自杀死亡IRR为0.8,但在确诊后首月高达3.0。亨廷顿病患者自杀死亡的绝对风险为1.6%。

研究发现,1980-2016年间,丹麦神经系统疾病确诊患者的自杀死亡风险高于其他疾病,但绝对风险仍保持较低水平。

原始出处:

Annette Erlangsen et al. Association Between Neurological Disorders and Death by Suicide in Denmark. JAMA. February 4, 2020

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    2020-02-05 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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