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Nutrients:维生素D3或可促进牙齿和面部骨骼的正常发育,预防错牙合!

2021-07-05 MedSci原创 MedSci原创

体内适当浓度的维生素D3或可以促进面部骨骼的正常发育。

下颌骨的生长发育受到各种遗传和环境因素、功能障碍和副功能(如拇指吮吸和口腔呼吸)的影响。颅面骨生长不足或过度会导致骨骼和牙齿缺损,进而导致错牙合。根据目前的Orlik-Grzybowska分类法,错牙合在矢状面、额面和水平面进行评估,并分为垂直面、水平面和横向面。有骨骼,牙齿和混合缺陷。

到目前为止,并不是所有错牙合的原因都得到了充分的解释。Moyers等人将错颌分为六类:遗传性、病因不明的发育性、创伤性、物理因素、习惯和疾病因素。在骨骼异常的发展过程中,人民通常会注意到一般的缺陷,包括维生素D3缺乏,众所周知缺乏维生素D将导致成长期的人佝偻病。而这种缺陷影响颌骨,可能与错咬合的发育有关。

基于这些,有研究者前瞻性地评估了维生素D缺乏对错牙合发育的影响。该研究结果近日发表在Nutrients期刊上。

2017年至2018年间,研究者在Wrocław的一家私人牙科诊所随机选取了一组患者进行了一项前瞻性观察性研究。分析对象包括男性和女性,年龄在18岁以上的白种人,他们因各种原因(通常是龋齿或正畸问题)前来治疗。检查由三部分组成:(1)医学访谈(2)口腔检查、藻酸盐印模、放射学成像(全景和头影测量)和正畸评估;(3)静脉采血检测维生素D3水平。

研究最后分析了114例患者(男53例,女61例),年龄18-50岁(平均36.5±11.8岁),已完成医学访谈,参加临床检查,并捐献血样进行实验室检测。

在研究组患者中,大多数人拒绝补充维生素D3 (73.6% n = 84)。只有将近四分之一的受访者愿意服用这种维生素(服用小剂量的维生素D3(500 2000国际单位/天),不服用钙和维生素K2)。

入选患者中,约42.1%的患者发现有骨骼缺陷。46.5%的患者出现牙槽畸形。以角型和犬齿类为多,最常见的缺损为上颌骨横向收缩,上弓狭窄(30.7%)。此外,85例患者出现拥挤,其中50例在下颌,35例在上颌。28.1%有牙周病,存在病理性牙周袋。近一半(50.5%)病例出现脱落和磨耗。

研究组维生素25(OH)D3浓度为7.8~57(ng/mL),平均为23.6~10.5(ng/mL)。根据所采用的代词值,86名受试者(75.4%)存在代词缺失;水平高达30 ng/mL。

比较不同维生素D3水平患者的定性特征和检测结果

研究没有评估维生素D水平对正畸治疗过程的影响。由于这是一项前瞻性观察研究,只有维生素D水平与错牙合或牙齿缺损的发生有关。回顾性分析上颌骨横行生长完成(的病例。维生素D水平低的患者要么根本不补充,要么补充剂量小,对维生素D水平没有显著影响。由于受访者人数相对较少,观察到的一些趋势导致了某些不具统计意义的结论:在维生素D3缺乏症患者中,更常观察到牙齿过载、骨骼缺损和牙齿拥挤。

上、下牙弓的牙齿拥挤和骨骼缺陷与维生素D低浓度的相关性更常见。48.1%的病例发生骨缺损。上牙弓狭窄在维生素D缺乏的患者中更常见。47.7%的病例发生了拥挤。此外,32.6%的维生素D缺乏症患者选择正畸治疗,这一比例远高于非维生素D缺乏症患者。

因此,体内适当浓度的维生素D3可以促进面部骨骼的正常发育。由于影响骨发育的因素更多,且受检查的患者组有限,因此这一结论还有待进一步推广。然而,目前的结果表明,有必要对这一主题进行更彻底的调查。

参考文献:Leszczyszyn, A.; Hnitecka, S.; Dominiak, M. Could Vitamin D3 Deficiency Influence Malocclusion Development? Nutrients 202113, 2122. https://doi.org/10.3390/nu13062122

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    2021-07-09 ms3000001999514966

    理学因素

    0

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    2021-07-07 ms2658711348342440

    所以要多晒太阳

    0

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    2021-07-07 neurowu
  5. [GetPortalCommentsPageByObjectIdResponse(id=1994485, encodeId=54bb199448507, content=<a href='/topic/show?id=b6e463201d4' target=_blank style='color:#2F92EE;'>#正常发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63201, encryptionId=b6e463201d4, topicName=正常发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Mar 29 04:34:30 CST 2022, time=2022-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997984, encodeId=b65d99e98461, content=理学因素, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62a85535130, createdName=ms3000001999514966, createdTime=Fri Jul 09 14:39:27 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997301, encodeId=605f99e30152, content=所以要多晒太阳, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f221859736, createdName=ms2658711348342440, createdTime=Wed Jul 07 20:54:58 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347561, encodeId=9485134e561e4, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Wed Jul 07 12:34:30 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430241, encodeId=a2ac143024133, content=<a href='/topic/show?id=b58f6e691fc' target=_blank style='color:#2F92EE;'>#牙齿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67691, encryptionId=b58f6e691fc, topicName=牙齿)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Jul 07 12:34:30 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996615, encodeId=fd8e996615c3, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jul 05 23:15:48 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996576, encodeId=b66c9965e600, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73b65416615, createdName=ms4000000622940391, createdTime=Mon Jul 05 22:02:22 CST 2021, time=2021-07-05, status=1, ipAttribution=)]
    2021-07-07 zhouqu_8
  6. [GetPortalCommentsPageByObjectIdResponse(id=1994485, encodeId=54bb199448507, content=<a href='/topic/show?id=b6e463201d4' target=_blank style='color:#2F92EE;'>#正常发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63201, encryptionId=b6e463201d4, topicName=正常发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Tue Mar 29 04:34:30 CST 2022, time=2022-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997984, encodeId=b65d99e98461, content=理学因素, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62a85535130, createdName=ms3000001999514966, createdTime=Fri Jul 09 14:39:27 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997301, encodeId=605f99e30152, content=所以要多晒太阳, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1f221859736, createdName=ms2658711348342440, createdTime=Wed Jul 07 20:54:58 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347561, encodeId=9485134e561e4, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Wed Jul 07 12:34:30 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430241, encodeId=a2ac143024133, content=<a href='/topic/show?id=b58f6e691fc' target=_blank style='color:#2F92EE;'>#牙齿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67691, encryptionId=b58f6e691fc, topicName=牙齿)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Jul 07 12:34:30 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996615, encodeId=fd8e996615c3, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Jul 05 23:15:48 CST 2021, time=2021-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996576, encodeId=b66c9965e600, content=1, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=73b65416615, createdName=ms4000000622940391, createdTime=Mon Jul 05 22:02:22 CST 2021, time=2021-07-05, status=1, ipAttribution=)]
    2021-07-05 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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    2021-07-05 ms4000000622940391

    1

    0

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