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J Infect Dis:门诊患呼吸道合胞病毒感染的病毒载量与疾病严重程度的关系

2020-02-20 不详 网络

目前关于门诊儿童病毒载量是否影响呼吸道合胞病毒(RSV)疾病严重程度的数据很少。方法我们分析了参加呼吸道感染前瞻性队列研究的儿童中病毒载量与疾病严重程度之间的关联。在每次呼吸系统疾病期间,对儿童进行了检查,并获得了鼻拭子以检测RSV。 RSV负载的定量基于循环阈值(Ct)值。为了进行初步分析,将儿童分为两组:较高(Ct <27)和较低病毒载量(Ct≥27)。结果,在201例RSV感染中,病毒

目前关于门诊儿童病毒载量是否影响呼吸道合胞病毒(RSV)疾病严重程度的数据很少。

方法我们分析了参加呼吸道感染前瞻性队列研究的儿童中病毒载量与疾病严重程度之间的关联。在每次呼吸系统疾病期间,对儿童进行了检查,并获得了鼻拭子以检测RSV。 RSV负载的定量基于循环阈值(Ct)值。为了进行初步分析,将儿童分为两组:较高(Ct <27)和较低病毒载量(Ct≥27)。

结果,在201例RSV感染中,病毒载量较高的儿童的鼻炎(8天比6天; P = .0008),咳嗽(8天比6天; P = .034),发烧(2天比1天) ; P = .018),以及任何症状(病毒载量较低的症状)(10 vs 8天; P = .024)中位持续时间明显更长。 Ct值与所有测得症状的持续时间之间存在显著的负相关。

综上所述,该研究结果表明,病毒载量会导致儿童RSV疾病的严重性。通过RSV抗病毒药降低病毒载量可能为门诊儿童带来巨大的好处。

原始出处:

Uusitupa E, Waris M, Heikkinen T. Association of Viral Load With Disease Severity in Outpatient Children With Respiratory Syncytial Virus Infection. J Infect Dis. 2020 Feb 18. pii: jiaa076. doi: 10.1093/infdis/jiaa076.

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