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Mol Biol Rep:过敏性鼻炎患者血清中转氨酶E1(RvE1)和白三烯B4(LTB4)水平失衡

2020-10-31 AlexYang MedSci原创

及时、成功地解决急性炎症对预防过敏性鼻炎(AR)慢性气道炎症的发展具有至关重要的作用。

及时、成功地解决急性炎症对预防过敏性鼻炎(AR)慢性气道炎症的发展具有至关重要的作用。

最近,有研究人员评估了AR患者外周血白细胞中促炎性白三烯B4(LTB4)、抗炎性介质(包括转氨酶E1(RvE1)、RvD1、IL-10和TGF-β)的血清水平,以及G-蛋白偶联受体120(GPR120)和过氧化物酶体增殖物激活受体-γ(PPAR-γ)受体的mRNA表达水平。研究包括了37名AR患者和30名年龄和性别匹配的健康受试者。研究人员使用了酶联免疫吸附试验(ELISA)测定了血清中LTB4、RvE1、RvD1、IL-10和TGF-β的水平,采用实时PCR方法评估了GPR120和PPAR-γ的mRNA表达水平。研究结果表明,AR患者血清中RvE1和LTB4的水平明显高于健康人(分别为P<0.01和P<0.0001)。然而,AR患者中RvE1和RvD1与LTB4的比值相对于健康受试者显著降低(分别为P<0.05和P<0.0001)。同时,AR患者血清中IL-10和TGF-β细胞因子的水平与健康受试者相比显著降低(分别为P<0.01和P<0.0001)。此外,AR患者PPAR-γ的mRNA表达量明显低于健康受试者(P<0.05)。

最后,研究人员指出,促炎脂质介质RvE1和促炎LTB4的失衡可能是AR患者气道炎症和随后慢性炎症发展的原因。

原始出处:

Ramin Lotfi , Akram Davoodi , Seyed Hamidreza Mortazavi et al. Imbalanced serum levels of resolvin E1 (RvE1) and leukotriene B4 (LTB4) in patients with allergic rhinitis. Mol Biol Rep. Sep 2020

 

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1800076, encodeId=c71d18000e694, content=<a href='/topic/show?id=64d7e1616c9' target=_blank style='color:#2F92EE;'>#白三烯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71616, encryptionId=64d7e1616c9, topicName=白三烯)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQHWdlyPWPmuHjfEXicudmC0dJ6SN5PHzglbDHibXpT1VXF2fKDnTzl2Eib4Pf94p58cnSKA3ZfGdFQ/132, createdBy=c44f2500101, createdName=ms2694732865965676, createdTime=Tue Feb 09 20:08:12 CST 2021, time=2021-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047329, encodeId=a0f2204e3292e, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Fri Apr 02 15:08:12 CST 2021, time=2021-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988892, encodeId=ca89198889218, content=<a href='/topic/show?id=bd15e161777' target=_blank style='color:#2F92EE;'>#白三烯B4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71617, encryptionId=bd15e161777, topicName=白三烯B4)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e05e201, createdName=appleandpeer, createdTime=Sat Jan 09 08:08:12 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767806, encodeId=f6071e678061d, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Tue Jul 27 02:08:12 CST 2021, time=2021-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054914, encodeId=6c6e2054914c0, content=<a href='/topic/show?id=69c9110e74c' target=_blank style='color:#2F92EE;'>#LTB4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11077, encryptionId=69c9110e74c, topicName=LTB4)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Thu Jun 03 14:08:12 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919162, encodeId=7ec11919162a7, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Sep 08 06:08:12 CST 2021, time=2021-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395470, encodeId=277013954e0c2, content=<a href='/topic/show?id=252d93386f8' target=_blank style='color:#2F92EE;'>#转氨酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93386, encryptionId=252d93386f8, topicName=转氨酶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Tue Nov 03 05:08:12 CST 2020, time=2020-11-03, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1800076, encodeId=c71d18000e694, content=<a href='/topic/show?id=64d7e1616c9' target=_blank style='color:#2F92EE;'>#白三烯#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71616, encryptionId=64d7e1616c9, topicName=白三烯)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQHWdlyPWPmuHjfEXicudmC0dJ6SN5PHzglbDHibXpT1VXF2fKDnTzl2Eib4Pf94p58cnSKA3ZfGdFQ/132, createdBy=c44f2500101, createdName=ms2694732865965676, createdTime=Tue Feb 09 20:08:12 CST 2021, time=2021-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047329, encodeId=a0f2204e3292e, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Fri Apr 02 15:08:12 CST 2021, time=2021-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988892, encodeId=ca89198889218, content=<a href='/topic/show?id=bd15e161777' target=_blank style='color:#2F92EE;'>#白三烯B4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71617, encryptionId=bd15e161777, topicName=白三烯B4)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e05e201, createdName=appleandpeer, createdTime=Sat Jan 09 08:08:12 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767806, encodeId=f6071e678061d, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Tue Jul 27 02:08:12 CST 2021, time=2021-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054914, encodeId=6c6e2054914c0, content=<a href='/topic/show?id=69c9110e74c' target=_blank style='color:#2F92EE;'>#LTB4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11077, encryptionId=69c9110e74c, topicName=LTB4)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/0EDD6BA8A8C6A0C23E8ABC8BA5331A25/100, createdBy=d37d2500154, createdName=ms5106640509429053, createdTime=Thu Jun 03 14:08:12 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1919162, encodeId=7ec11919162a7, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Sep 08 06:08:12 CST 2021, time=2021-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395470, encodeId=277013954e0c2, content=<a href='/topic/show?id=252d93386f8' target=_blank style='color:#2F92EE;'>#转氨酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93386, encryptionId=252d93386f8, topicName=转氨酶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Tue Nov 03 05:08:12 CST 2020, time=2020-11-03, status=1, ipAttribution=)]
    2021-09-08 sunylz
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张先生,男性,45岁,自幼经母亲垂直感染患乙肝,为“小三阳”,HBV DNA也一直阳性,既往每年单位体检,肝功能正常,自以为携带者,两年来,体查肝功能谷丙转氨酶(ALT)轻度升高40~100U/L左右,体重150Kg,身高174CM,血脂胆固醇轻度升高,血糖正常,查B超也提示轻度脂肪肝,我院肝脂肪测定,肝硬度测定均提示轻度脂肪肝,轻度肝纤维化,那么张先生的ALT升高是慢性乙肝引起还是脂肪肝引起呢?

J Periodontol: 拉美裔人群牙周炎与转氨酶升高的研究

西班牙裔/拉美裔人群中,非酒精性脂肪性肝病(NAFLD)患病率比其他种族/族裔群体更高,据报道,西班牙裔/拉丁裔群体的患病率也有所不同。实验动物和人类研究表明牙周炎与NAFLD之间存在关联,但尚未在西班牙裔/拉丁美洲人中报道。本研究将牙周炎作为一种新的危险因素进行了研究,该因素可能导致西班牙裔/拉美裔人群中NAFLD的负担。

J Viral Hepatitis:转氨酶2倍以内慢性乙型肝炎患者抗病毒治疗决策的临床无创指标

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转氨酶升高,到底是乙肝还是脂肪肝导致的?

张先生,男,45岁,自幼经母亲垂直感染患乙肝,为“小三阳”,HBV DNA也一直阳性,既往每年单位体检,肝功能正常,自以为携带者。

病例分析:扑朔迷离的转氨酶升高,原因竟是它?

患儿女,5岁,因“发现肝功异常2天”入院。2天前体检时发现转氨酶升高,无发热、咳嗽,无特殊外貌及特殊体味,无皮肤黄染,无出血倾向,精神食纳可,大小便正常。既往体健,入院前服用中药1月,无毒物和其他药物接触史,家族中无传染病史及肝病史。

病例分享:转氨酶升高、肝肿大待查1例——竟与罕见遗传性糖原累积病有关

GSD是一种罕见的遗传性糖原代谢异常性疾病,其遗传方式大多数为常染色体隐性遗传,个别类型为伴X染色体遗传。由于糖原在转化为葡萄糖的代谢过程中出现异常,从而导致过多或异常糖原蓄积在肝脏及其他组织器官中。

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