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Stroke:无症状颈动脉动脉粥样硬化病人静息性脑梗死

2016-04-04 MedSci MedSci原创

研究背景及研究目的:颈动脉粥样硬化及同侧静息性脑梗死(SBI)之间的关系尚不清楚。我们验证颈内动脉(ICA)颅外段狭窄和同侧大脑半球静息性脑梗死之间的关系比对侧无颈内动脉颅外段狭窄的相关性更强。

研究背景及研究目的:颈动脉粥样硬化及同侧静息性脑梗死(SBI)之间的关系尚不清楚。我们验证颈内动脉(ICA)颅外段狭窄和同侧大脑半球静息性脑梗死之间的关系比对侧无颈内动脉颅外段狭窄的相关性更强。

研究方法:我们识别按照标准造影显示有单侧ICA狭窄≥50%的病人。并纳入近期头颅磁共振提示没有卒中史及短暂性脑缺血发作的病人。盲法的读片者确定前循环静息性脑梗死的发生。SBI被定义为表现为T2高信号的白质区,皮质下或皮质的腔梗。威尔克森符号等级检定用于比较大脑半球SBI,Cohen κ用于评估SBI评估评定者间可信度。

研究结果:在104个病人中,我们发现与ICA疾病对侧SBI发生率(20.8%)相比,同侧发生率(33%)更高( P=0.0067)。在两侧半球中腔隙性SBIs(包括白质及皮质下)的发生率没有显著差异(P=0.109),但是皮质SBIs在ICA疾病侧发生率更高(P=0.0045)。观察者间可信度较高(κ=0.818)。

研究结论:无症状ICA疾病的病人有同侧SBI更高的发生率同对侧相比。但仅限于皮质SBI,而不是别的腔隙性SBI亚型。

原始出处:

Baradaran H1, Gialdini G1, Mtui E1, Askin G1, Kamel H1, Gupta A2.et al,Silent Brain Infarction in Patients With Asymptomatic Carotid Artery Atherosclerotic Disease.Stroke. 2016 Mar 31. pii: STROKEAHA.116.013193.


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    2016-04-05 karmond
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