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Diabetologia:盐摄入过多或增加糖尿病肾病风险

2014-10-13 desperado-c 丁香园

膳食中食盐摄入增加可导致血压水平升高,并可对微血管并发症产生不良影响。但是,钠和钾摄入量与 1 型糖尿病微血管并发症之间的关系尚未明确。 为此,来自荷兰马斯特里赫特大学医学中心的 Lian Engelen 教授及其团队进行了一项研究,探讨膳食中食盐摄入量(通过 24 小时尿钠排泄量进行估算)和尿钾排泄量与 1

膳食中食摄入增加可导致血压水平升高,并可对微血管并发症产生不良影响。但是,钠和钾摄入量与 1 型糖尿病微血管并发症之间的关系尚未明确。

为此,来自荷兰马斯特里赫特大学医学中心的 Lian Engelen 教授及其团队进行了一项研究,探讨膳食中食盐摄入量(通过 24 小时尿钠排泄量进行估算)和尿钾排泄量与 1 型糖尿病微血管并发症患病率之间的关系。该研究结果发表在 2014 年 11 月的 Diabetologia 杂志上。

该研究对 EURODIAB 前瞻性并发症研究中 1212 例 1 型糖尿病患者(年龄为 40±10 岁,男性占 51%)进行分析,测量患者留取的两份 24 小时尿液标本中钠和钾浓度。利用多元 logistic 回归分析调查患者膳食中食盐摄入量与微血管并发症之间的关系。

该研究发现,校正年龄、性别、BMI、吸烟、尿钾排泄量、降压药使用情况、体力活动水平、以及总能量、蛋白、酒精、饱和脂肪酸和纤维素摄入量后,膳食中食盐摄入量>1g/ 天与微量白蛋白尿发生呈正相关,但与大量白蛋白尿、非增值性视网膜病变、以及增值性视网膜病变发生无关。排除伴有心血管疾病和服用降压药的患者后,分析发现膳食中食盐摄入量与微量白蛋白尿和大量白蛋白尿都无明显相关性。此外,与 BMI<25kg/m2 患者相比,BMI≥25kg/m2 患者膳食中食盐摄入量与微量白蛋白尿之间的相关性更强。但是,整个研究期间,未发现尿钾排泄量与各种微血管并发症之间有任何相关性。

该研究提示,1 型糖尿病患者膳食中食盐摄入量(通过 24 小时尿钠排泄量确定)增加与微量白蛋白尿发生呈正相关,尤其是超重患者。

原始出处:

Engelen L1, Soedamah-Muthu SS, Geleijnse JM, Toeller M, Chaturvedi N, Fuller JH, Schalkwijk CG, Stehouwer CD.Higher dietary salt intake is associated with microalbuminuria, but not with retinopathy in individuals with type 1 diabetes: the EURODIAB Prospective Complications Study.Diabetologia. 2014 Nov;57(11):2315-23. doi: 10.1007/s00125-014-3367-9. Epub 2014 Aug 30.[pdf free]

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    2015-07-21 智智灵药
  2. [GetPortalCommentsPageByObjectIdResponse(id=1759496, encodeId=244b1e5949605, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Tue Jul 21 17:33:00 CST 2015, time=2015-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26097, encodeId=1fdb2609e14, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=196, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Fri Jun 05 16:30:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20539, encodeId=6bfb2053903, content=控制好糖尿病可能提高肝硬化患者的预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:08:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20538, encodeId=9ab220538f8, content=控制好糖尿病可能提高肝硬化患者的预后。, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Sat Apr 11 23:07:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636949, encodeId=8c7216369494b, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Aug 04 16:33:00 CST 2015, time=2015-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988905, encodeId=4fb719889057e, content=<a href='/topic/show?id=737ce226189' target=_blank style='color:#2F92EE;'>#盐摄入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72261, encryptionId=737ce226189, topicName=盐摄入)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Thu Oct 23 13:33:00 CST 2014, time=2014-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=12224, encodeId=35c21222496, content=这个内容确实让人眼睛一亮,饮食对健康的影响确实值得人们关注。, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3791485548, createdName=imp_liusongfang5341, createdTime=Thu Oct 16 17:16:00 CST 2014, time=2014-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=12137, encodeId=bbf71213e94, content=这个对我帮助很大,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=230, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87d138660, createdName=wugerde, createdTime=Mon Oct 13 14:30:00 CST 2014, time=2014-10-13, status=1, ipAttribution=)]
    2015-06-05 ljjj1053

    好好学习学习

    0

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    2015-04-11 x35042875

    控制好糖尿病可能提高肝硬化患者的预后。

    0

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    2015-04-11 x35042875

    控制好糖尿病可能提高肝硬化患者的预后。

    0

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    2014-10-16 imp_liusongfang5341

    这个内容确实让人眼睛一亮,饮食对健康的影响确实值得人们关注。

    0

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    2014-10-13 wugerde

    这个对我帮助很大,谢谢!

    0

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