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Circulation:膳食Omega-6脂肪酸生物标志物与心血管疾病和死亡率

2019-04-12 xing.T 网络

由此可见,在汇总的全球分析中,较高的体内循环和组织LA水平和可能的AA与较高的主要心血管事件风险相关。这些结果支持LA在CVD预防中的有利作用。

亚油酸(主要膳食中的ω-6脂肪酸及其主要代谢产物花生四烯酸)的全球饮食建议和血管效应仍存在争议。为了解决这种不确定性并为国际建议提供信息,近日,血管领域权威杂志Circulation上发表了一篇研究文章,研究人员评估了多种国际研究中亚油酸(LA)和花生四烯酸(AA)的体内循环和组织水平,以及与心血管疾病(CVD)之间的关系。 

研究人员在来自13个国家的30项前瞻性观察研究的全球联盟中进行了协调、从头和个体层面的分析。根据预先指定的分析计划分析了循环和脂肪组织中LA和AA生物标志物与总体CVD和亚型(冠心病(CHD)、缺血性卒中、心血管死亡率)的多变量调整关联。以总脂肪酸的%衡量LA和AA的水平,并根据它们的间距范围(即第一和第五五分位数的中点之间的范围)进行线性地评估,并且通过五分位数进行分类评估。研究人员使用逆方差加权荟萃分析汇总研究特异性结局。通过年龄、性别、种族、糖尿病、他汀类药物使用、阿司匹林使用、ω-3水平和脂肪酸去饱和酶1基因型(如果可用)来探索异质性。

在随访中位数为2.5至31.9岁的30项前瞻性研究中,68659名参与者中发生了15198例心血管事件。较高水平的LA与总CVD、心血管死亡率和缺血性卒中风险降低显著相关,每个组合的风险比范围为0.93(95%CI为0.88-0.99)、0.78(0.70-0.85)和0.88(0.79-0.98),并与CHD风险较低(0.94; 0.88-1.00)无显著相关。在五分位数评估LA的关系是相似的。AA水平与心血管结局风险较高无关;比较极端五分位数,较高水平与较低的总CVD风险相关(0.92; 0.86-0.99)。在观察到的关系中未发现人口亚群的一致异质性。

由此可见,在汇总的全球分析中,较高的体内循环和组织LA水平和可能的AA与较高的主要心血管事件风险相关。这些结果支持LA在CVD预防中的有利作用。 

原始出处:

Matti Marklund,et al.Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality: An Individual-Level Pooled Analysis of 30 Cohort Studies. Circulation. 2019. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.038908

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1841379, encodeId=b3c618413e903, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Nov 02 15:55:00 CST 2019, time=2019-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2007545, encodeId=ad7b200e5451c, content=<a href='/topic/show?id=33141333248' target=_blank style='color:#2F92EE;'>#Omega-6脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13332, encryptionId=33141333248, topicName=Omega-6脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Sun Apr 14 13:55:00 CST 2019, time=2019-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350393, encodeId=21641350393c6, content=<a href='/topic/show?id=224a85904ad' target=_blank style='color:#2F92EE;'>#膳食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85904, encryptionId=224a85904ad, topicName=膳食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Apr 14 05:55:00 CST 2019, time=2019-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498558, encodeId=dbbe149855800, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Apr 14 05:55:00 CST 2019, time=2019-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560820, encodeId=00f31560820ec, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sun Apr 14 05:55:00 CST 2019, time=2019-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566829, encodeId=8c6f156682967, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sun Apr 14 05:55:00 CST 2019, time=2019-04-14, status=1, ipAttribution=)]
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