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Exp Physiol:如何预防胰岛素抵抗与随之而来的糖尿病?

2017-06-24 sunshine2015 来宝网

近期,上海交通大学药学院李大伟教授课题组经过多年研究在肿瘤治疗新靶点研究方面取得重大突破,其研究揭示了乳腺癌中高表达的人前梯度蛋白 2(AGR2)在肿瘤发生发展中的新作用机制。同时,根据相关机制开发的人源化抗体药物 Agtuzumab(18A4Hu)在抗肿瘤及药物联用方面也表现出了优良的治疗效果,相关的一系列研究发表在今年 5 月 8 日的 Nature 子刊《Oncogene》上以及 2016



科学家阐明糖尿病预防措施少量的身体活动可以提供保护胰岛素抵抗的健康益处,胰岛素抵抗是2型糖尿病的前兆,可以由高脂肪饮食引起。这就是实验生理学中发现的研究结果。他们的研究也提出了以前认为增加线粒体数量的疑问 - 线粒体数量是将葡萄糖和脂肪转化为能量的细胞中的微小结构,将有助于修复高脂肪饮食的一些症状。研究人员发现,体力活动的好处不受实验增强线粒体数量的影响。

胰岛素是一种用于控制血糖水平的激素。高脂肪饮食有助于胰岛素抵抗的发展,当他们的肌肉,脂肪和肝细胞对胰岛素没有适当的反应便导致2型糖尿病的发展。

Megan E. Rosa-Caldwell博士,Nicholas P. Greene博士和阿肯色大学综合肌肉代谢实验室的研究小组发现,基因工程改造成具有较高线粒体数量的小鼠没有得到更多的保护,脂肪饮食诱导胰岛素抵抗。研究人员在研究中为所有的小鼠喂食了模仿西方饮食——高脂肪的饮食。将基因工程和对照小鼠进一步分为允许运动的组和久坐组。

他们的研究结果表明,无论线粒体数量多少,身体活动对胰岛素抵抗都有类似的健康益处。似乎锻炼能够帮助去除损伤的细胞并提高线粒体的质量可能更有效地预防胰岛素抵抗。然而,这些方面需要进一步测试。

随着肥胖和2型糖尿病的持续增加,了解有助于或损害胰岛素抵抗的细胞过程可以帮助我们更好地定制有效的预防措施,如运动。

本文的主要作者Rosa-Caldwell女士说:“现在身体活动是最大的保护,但进一步的研究可能使我们能够更有效地预防和治疗胰岛素抵抗和随之而来的糖尿病。”

原始出处:

Megan E. Rosa-Caldwell, Jacob L. Brown, David E. Lee, et al. Autophagy activation, not PGC-1α, may mediate exercise-induced improvements in glucose handling during diet-induced obesity. Experimental Physiology, doi: 10.1113/EP086406, published 22 June 2017.

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    2018-01-24 baoya
  2. [GetPortalCommentsPageByObjectIdResponse(id=1749763, encodeId=229a1e4976365, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Wed Jan 24 20:33:00 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788811, encodeId=7a071e8881118, content=<a href='/topic/show?id=866d1421e4c' target=_blank style='color:#2F92EE;'>#Physio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14217, encryptionId=866d1421e4c, topicName=Physio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Sep 26 11:33:00 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214845, encodeId=ab3f214845e3, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Jun 24 15:24:04 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214800, encodeId=aafe214800de, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sat Jun 24 12:19:59 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214759, encodeId=a311214e597d, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 24 10:52:00 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1749763, encodeId=229a1e4976365, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Wed Jan 24 20:33:00 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788811, encodeId=7a071e8881118, content=<a href='/topic/show?id=866d1421e4c' target=_blank style='color:#2F92EE;'>#Physio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14217, encryptionId=866d1421e4c, topicName=Physio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Sep 26 11:33:00 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214845, encodeId=ab3f214845e3, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Jun 24 15:24:04 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214800, encodeId=aafe214800de, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sat Jun 24 12:19:59 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214759, encodeId=a311214e597d, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 24 10:52:00 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
    2017-06-24 天涯183

    非常好的文章,学习了,很受益

    0

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    2017-06-24 dhzzm

    学习了分享了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1749763, encodeId=229a1e4976365, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Wed Jan 24 20:33:00 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788811, encodeId=7a071e8881118, content=<a href='/topic/show?id=866d1421e4c' target=_blank style='color:#2F92EE;'>#Physio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14217, encryptionId=866d1421e4c, topicName=Physio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Sep 26 11:33:00 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214845, encodeId=ab3f214845e3, content=非常好的文章,学习了,很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Jun 24 15:24:04 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214800, encodeId=aafe214800de, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sat Jun 24 12:19:59 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214759, encodeId=a311214e597d, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 24 10:52:00 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
    2017-06-24 Y—xianghai

    学习了新知识

    0

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