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Brit J Surg:甲状腺髓样癌患者术后并发症

2020-11-24 MedSci原创 MedSci原创

MTC术后并发症是手术特异性的,可能与某些患者需要进行根治性切除不可避免的结果有关。

手术是甲状腺髓样癌(MTC)患者的根治手段。在确定手术范围时,应考虑并发症风险。近日,外科疾病领域权威杂志British Journal of Surgery上发表了一篇研究文章,这项研究旨在评估MTC术后并发症的手术特异性结局和危险因素。

研究人员在两个欧洲前瞻性质量数据库中确定了接受甲状腺手术的MTC患者。甲状旁腺功能减退症是通过补钙/活性维生素D治疗来确定。喉镜检查可诊断出喉返神经麻痹。如果在最后一次随访中发生并发症,则至少是暂时的。研究人员通过Logistic回归分析确定了至少一次短暂性甲状旁腺功能低下和RLN麻痹的危险因素。

该研究共纳入了650名患者,这些患者分布在69个中心接受了手术,中位年龄为56岁。分别有170名(26.2%)、62名(13.7%)和17名(2.6%)患者出现甲状旁腺功能低下、RLN麻痹和需要再次手术的出血。与甲状旁腺功能低下有关的因素包括中央淋巴结清扫术(CLND)(比值比(OR)为2.20,95%CI为1.04至4.67)、CLND加上单侧外侧淋巴结清扫术(LLND)(OR为2.78,1.20至6.43)、CLND加双侧LLND(OR为2.83,1.13至7.05)和观察到四个或更多甲状旁腺(OR为4.18,1.46至12.00)。RLN麻痹与CLND加LLND(OR为4.04,1.12至14.58)和T4肿瘤(OR为12.16,4.46至33.18)相关。隔室定向淋巴结清扫后,537例患者中有248例达到N0状态(46.2%)。

由此可见,MTC术后并发症是手术特异性的,可能与某些患者需要进行根治性切除不可避免的结果有关。

原始出处:

J. van Beek,et al.Complications after medullary thyroid carcinoma surgery: multicentre study of the SQRTPA and EUROCRINE databases.British Journal of Surgery.2020.https://bjssjournals.onlinelibrary.wiley.com/doi/10.1002/bjs.12055

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    2021-03-19 丁鹏鹏
  2. [GetPortalCommentsPageByObjectIdResponse(id=1758297, encodeId=e0c41e58297ee, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Fri Mar 19 21:26:12 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822009, encodeId=5dc31822009ff, content=<a href='/topic/show?id=26091021157a' target=_blank style='color:#2F92EE;'>#髓样癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102115, encryptionId=26091021157a, topicName=髓样癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sat Jan 02 13:26:12 CST 2021, time=2021-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910217, encodeId=0c9791021ee7, content=这种并发症是都会出现还是有个体差异性?, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=31745400749, createdName=ms6000001296915076, createdTime=Tue Dec 22 22:36:35 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902375, encodeId=cb259023e52c, content=MTC术后并发症是手术特异性的,可能与某些患者需要进行根治性切除不可避免的结果有关。<a href='/topic/show?id=bec66989e9a' target=_blank style='color:#2F92EE;'>#甲状腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=211, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69897, encryptionId=bec66989e9a, topicName=甲状腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Thu Nov 26 08:24:18 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902207, encodeId=998690220e33, content=MTC术后并发症是手术特异性的,可能与某些患者需要进行根治性切除不可避免的结果有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Wed Nov 25 15:55:34 CST 2020, time=2020-11-25, status=1, ipAttribution=)]
    2021-01-02 Boyinsh
  3. [GetPortalCommentsPageByObjectIdResponse(id=1758297, encodeId=e0c41e58297ee, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Fri Mar 19 21:26:12 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822009, encodeId=5dc31822009ff, content=<a href='/topic/show?id=26091021157a' target=_blank style='color:#2F92EE;'>#髓样癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102115, encryptionId=26091021157a, topicName=髓样癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sat Jan 02 13:26:12 CST 2021, time=2021-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910217, encodeId=0c9791021ee7, content=这种并发症是都会出现还是有个体差异性?, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=31745400749, createdName=ms6000001296915076, createdTime=Tue Dec 22 22:36:35 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902375, encodeId=cb259023e52c, content=MTC术后并发症是手术特异性的,可能与某些患者需要进行根治性切除不可避免的结果有关。<a href='/topic/show?id=bec66989e9a' target=_blank style='color:#2F92EE;'>#甲状腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=211, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69897, encryptionId=bec66989e9a, topicName=甲状腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Thu Nov 26 08:24:18 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902207, encodeId=998690220e33, content=MTC术后并发症是手术特异性的,可能与某些患者需要进行根治性切除不可避免的结果有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Wed Nov 25 15:55:34 CST 2020, time=2020-11-25, status=1, ipAttribution=)]
    2020-12-22 ms6000001296915076

    这种并发症是都会出现还是有个体差异性?

    0

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    2020-11-26 Oranhyg

    MTC术后并发症是手术特异性的,可能与某些患者需要进行根治性切除不可避免的结果有关。#甲状腺癌#

    0

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    2020-11-25 rayms

    MTC术后并发症是手术特异性的,可能与某些患者需要进行根治性切除不可避免的结果有关。

    0

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