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Diabetologia：口服丁酸盐不影响1型糖尿病患者的先天免疫和胰岛自身免疫？

2020-04-12 MedSci原创 MedSci原创

先天免疫；胰岛自身免疫
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丁酸盐补充可以预防小鼠自身免疫性糖尿病。1型糖尿病的病理生理学与肠道菌群的改变有关。

丁酸盐补充可以预防小鼠自身免疫性糖尿病。1型糖尿病的病理生理学与肠道菌群的改变有关，更具体地说，与短链脂肪酸(SCFA)丁酸盐在肠道内产生不足有关，丁酸盐可能在维持肠道上皮完整和人体及肠道微生物代谢方面发挥关键作用。因此，我们研究口服丁酸盐与安慰剂对长期1型糖尿病患者血糖调节和免疫变量的影响。

研究人员在一个随机(1:1)、对照、双盲交叉试验中，每天给30名长期患有1型糖尿病的患者口服4克丁酸钠或安慰剂，洗脱期为1个月。受试者被随机分配到 "先口服丁酸钠胶囊 "或 "先口服安慰剂胶囊 "研究组，每组5人。临床研究者从临床试验药房接受盲目用药。所有参与者、做测量或检查的人或评估结果的人都是盲目的组别分配。主要结局是先天性免疫表型的变化（单核细胞亚群和体外细胞因子的产生）。次要结果是血小板自身免疫的血液标志物（细胞计数、淋巴细胞刺激指数和CD8量子点测定）、葡萄糖和脂质代谢、β细胞功能（通过混合膳食试验）、肠道微生物群和粪便SCFA的变化。这些数据是在阿姆斯特丹大学医学中心收集的。

对所有30名参与者进行了分析。口服丁酸盐对粪便丁酸盐和丙酸盐水平有显著影响，丁酸盐治疗是安全的。然而，这种肠道SCFAs的调节并没有导致适应性或先天免疫或其他结果变量的任何显著变化。在我们的讨论中，我们将详细阐述这一与以往动物研究的重要差异。

研究表明，口服丁酸盐对长期1型糖尿病患者的先天或适应性免疫没有显著影响。

原始出处：

Pieter F. de Groot， Tatjana Nikolic,Oral butyrate does not affect innate immunity and islet autoimmunity in individuals with longstanding type 1 diabetes: a randomised controlled trial

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    2022-09-17 小小医者

    口服#丁酸盐#不影响1型#糖尿病#患者的先天免疫和胰岛#自身免疫#？丁酸盐目前认为是#肠道微生物#中产生的有益成分，与很多代谢，#衰老#，#免疫#等疾病相关

    0

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    2020-08-03 ms5439512287675881

    #BET#

    0

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    2020-08-13 ms9608593228839890

    #DIA#

    0

  4. 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    2021-01-01 millore

    #1型糖尿病患者#

    0

  5. 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    2020-06-09 baoya

    #胰岛#

    0

  6. 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likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Apr 13 00:54:58 CST 2020, time=2020-04-13, status=1, ipAttribution=)]
    2020-04-14 xue8604

    #糖尿病患者#

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=1639434, encodeId=b0fc1639434ba, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Aug 13 12:54:58 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968303, encodeId=e5951968303fa, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Fri Jan 01 01:54:58 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1750148, encodeId=18d31e5014813, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Tue Jun 09 10:54:58 CST 2020, time=2020-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474914, encodeId=541d14e4914e4, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Tue Apr 14 12:54:58 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585824, encodeId=0a24158582499, content=<a href='/topic/show?id=4ec1285864b' target=_blank style='color:#2F92EE;'>#先天免疫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28586, encryptionId=4ec1285864b, topicName=先天免疫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50ec17296275, createdName=liubm561, createdTime=Tue Apr 14 12:54:58 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043070, encodeId=562710430e043, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Apr 13 00:54:58 CST 2020, time=2020-04-13, status=1, ipAttribution=)]
    2020-04-14 liubm561

    #先天免疫#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1249533, encodeId=9bca124953301, content=口服<a href='/topic/show?id=239a1043841e' target=_blank style='color:#2F92EE;'>#丁酸盐#</a>不影响1型<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>患者的先天免疫和胰岛<a href='/topic/show?id=a9d886328a0' target=_blank style='color:#2F92EE;'>#自身免疫#</a>？丁酸盐目前认为是<a href='/topic/show?id=b1fd816e094' target=_blank style='color:#2F92EE;'>#肠道微生物#</a>中产生的有益成分，与很多代谢，<a href='/topic/show?id=4c239032154' target=_blank style='color:#2F92EE;'>#衰老#</a>，<a href='/topic/show?id=f61b2894204' target=_blank style='color:#2F92EE;'>#免疫#</a>等疾病相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104384, encryptionId=239a1043841e, topicName=丁酸盐), TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病), TopicDto(id=86328, encryptionId=a9d886328a0, topicName=自身免疫), TopicDto(id=81670, encryptionId=b1fd816e094, topicName=肠道微生物), TopicDto(id=90321, encryptionId=4c239032154, topicName=衰老), TopicDto(id=28942, encryptionId=f61b2894204, topicName=免疫)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=小小医者, createdTime=Sat Sep 17 06:42:37 CST 2022, time=2022-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761386, encodeId=73331e6138685, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon Aug 03 04:54:58 CST 2020, time=2020-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639434, encodeId=b0fc1639434ba, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Aug 13 12:54:58 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968303, encodeId=e5951968303fa, content=<a href='/topic/show?id=a4b96e542' target=_blank style='color:#2F92EE;'>#1型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=675, encryptionId=a4b96e542, topicName=1型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0e3195, createdName=millore, createdTime=Fri Jan 01 01:54:58 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1750148, encodeId=18d31e5014813, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Tue Jun 09 10:54:58 CST 2020, time=2020-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474914, encodeId=541d14e4914e4, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Tue Apr 14 12:54:58 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1585824, encodeId=0a24158582499, content=<a href='/topic/show?id=4ec1285864b' target=_blank style='color:#2F92EE;'>#先天免疫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28586, encryptionId=4ec1285864b, topicName=先天免疫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50ec17296275, createdName=liubm561, createdTime=Tue Apr 14 12:54:58 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043070, encodeId=562710430e043, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon Apr 13 00:54:58 CST 2020, time=2020-04-13, status=1, ipAttribution=)]
    2020-04-13 misszhang

    谢谢MedSci提供最新的资讯

    0

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