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Hypertension:环氧化酶-2通过PPARβ/δ依赖性血管扩张信号通路选择性地调控肾血流量。

2018-01-04 MedSci MedSci原创

环氧化酶-2(COX-2)是一种在炎症和癌症中诱导表达的酶,非甾体类抗炎药物的靶点。COX-2同时还在某些重要位置基础性表达,这种位置的COX-2受抑制后会促使出现胃肠和心血管/肾脏的副作用。肾脏基础性表达的COX-2可调控肾功能和肾血流量;但,肾脏对比其他组织血流量调控对COX-2依赖性的总体相关性尚不是很清楚。在本研究中,研究人员利用微球沉积技术和COX-2抑制剂,映射COX-2对小鼠局部血流

环氧化酶-2(COX-2)是一种在炎症和癌症中诱导表达的酶,非甾体类抗炎药物的靶点。COX-2同时还在某些重要位置基础性表达,这种位置的COX-2受抑制后会促使出现胃肠和心血管/肾脏的副作用。

肾脏基础性表达的COX-2可调控肾功能和肾血流量;但,肾脏对比其他组织血流量调控对COX-2依赖性的总体相关性尚不是很清楚。

在本研究中,研究人员利用微球沉积技术和COX-2抑制剂,映射COX-2对小鼠局部血流量的影响,同时与COX-2的表达模式进行对比。所有受研究的组织中,抑制COX-2主要改变肾脏的血流量,对脾脏、脂肪和睾丸的血流量也有一定的影响。

研究人员进一步对肾血管应答的信号通路进行分析发现,COX-2对肾血管功能的保护作用通过PPARβ/δ(过氧化物酶体增殖物激活受体β/δ)介导的前列环素信号。

上述数据表明,COX-2主要调节肾脏的血流量,机制是既往未报道过的PPARβ/δ介导的肾血管扩张信号通路。总而言之,本研究揭示了为何抑制COX-2的药物会有肾脏和心血管的副作用,并提示COX-2/前列环素/PPARβ/δ轴可作为肾脏疾病的潜在治疗靶点。

原始出处:

Nicholas S. Kirkby,et al.Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel PPARβ/δ-Dependent Vasodilator Pathway.Hypertension. January 02,2018.https://doi.org/10.1161/HYPERTENSIONAHA.117.09906

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    2018-08-26 lsj637
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  8. 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12:44:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539650, encodeId=fb5515396508a, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sat Jan 06 12:44:00 CST 2018, time=2018-01-06, status=1, ipAttribution=)]
    2018-01-12 虈亣靌

    谢谢分享.学习了

    0

  9. 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  10. 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