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Dig Dis Sci: 益生菌和合生元在非酒精性脂肪性肝病患者中的疗效

2019-07-06 不详 MedSci原创

流行病学证据表明,非酒精性脂肪性肝病(NAFLD)是世界范围内的主要慢性肝病。然而,一些研究表明益生菌和合生元补充剂能够减轻肝病患者的肝脏损伤。因此,本项研究旨在探明二者的关系。

背景和目的
流行病学证据表明,非酒精性脂肪性肝病(NAFLD)是世界范围内的主要慢性肝病。然而,一些研究表明益生菌和合生元补充剂能够减轻肝病患者的肝脏损伤。因此,本项研究旨在探明二者的关系。

方法
研究人员系统地搜索了PubMed,Cochrane和Embase数据库,将收集到的所有文献按照Cochrane Risk of Bias Tool评估研究质量。

结果
本项研究共纳入15项随机对照试验,涉及782例NAFLD患者。益生菌和合生元补充剂可显着改善肝脏脂肪变性,丙氨酸氨基转移酶,天冬氨酸氨基转移酶,甘油三酯,总胆固醇,高密度脂蛋白,低密度脂蛋白(P<0.05)。但补充不能改善体重指数(P= 0.99),腰围和空腹血糖(P = 0.39)。

结论
本项Meta分析证明益生菌和合生元补充剂对NAFLD患者的肝脂肪变性,肝酶,脂质谱和肝硬度有益。

原始出处:

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  8. [GetPortalCommentsPageByObjectIdResponse(id=1673500, encodeId=e45016e3500a3, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Wed Dec 11 04:07:00 CST 2019, time=2019-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810135, encodeId=87b4181013520, content=<a href='/topic/show?id=70f484349b5' target=_blank style='color:#2F92EE;'>#脂肪性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84349, encryptionId=70f484349b5, topicName=脂肪性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 27 06:07:00 CST 2020, time=2020-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013046, encodeId=f9562013046f6, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Dec 31 04:07:00 CST 2019, time=2019-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1676493, encodeId=d28516e649313, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d18c27357544, createdName=Tommy1958, createdTime=Tue Nov 12 20:07:00 CST 2019, time=2019-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1654032, encodeId=587a165403224, content=<a href='/topic/show?id=1e1584351b2' target=_blank style='color:#2F92EE;'>#脂肪性肝病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84351, encryptionId=1e1584351b2, topicName=脂肪性肝病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c46224431741, createdName=wwzzly, createdTime=Wed Jul 24 23:07:00 CST 2019, time=2019-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2017969, encodeId=2748201e9697f, content=<a href='/topic/show?id=41ab81258fb' target=_blank style='color:#2F92EE;'>#肝病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81258, encryptionId=41ab81258fb, topicName=肝病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Tue Dec 24 13:07:00 CST 2019, time=2019-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435058, encodeId=d13e1435058af, content=<a href='/topic/show?id=23a938869f8' target=_blank style='color:#2F92EE;'>#合生元#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38869, encryptionId=23a938869f8, topicName=合生元)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jul 08 11:07:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369194, encodeId=51d8369194ea, content=666, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/04/2540fb84decb81d47a7f2868070e6cbd.jpg, createdBy=ed3f2205793, createdName=百草, createdTime=Sat Jul 06 23:13:10 CST 2019, time=2019-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032215, encodeId=0f1e10322151d, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sat Jul 06 23:07:00 CST 2019, time=2019-07-06, status=1, ipAttribution=)]
    2019-07-06 百草

    666

    0

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    2019-07-06 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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