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Dermatol Surg:不同密度二氧化碳点阵激光治疗烧伤后肥厚疤痕的疗效对比

2021-08-20 MedSci原创 MedSci原创

既往研究已证实二氧化碳点阵激光在改善增生性烧伤疤痕的色素沉着、瘙痒和紧绷方面有效。然而,对于最佳治疗参数还没有达成共识。

既往研究已证实二氧化碳点阵激光在改善增生性烧伤疤痕的色素沉着、瘙痒和紧绷方面有效。然而,对于最佳治疗参数还没有达成共识

 

近日,发表于Dermatol Surg的一项研究比较了不同密度的二氧化碳点阵激光在治疗成熟肥厚烧伤疤痕方面的效果。

研究共纳入25名患者,均有3个或更多的成熟增生性烧伤疤痕。按照疤痕数目随机分配到低、中、高密度的二氧化碳点阵激光治疗。每个疤痕接受3次激光治疗,间隔时间为1个月。使用温哥华疤痕量表(VSS)和患者及观察者疤痕评估量表(POSAS)分数对改善程度进行临床评估,并通过治疗前和治疗结束后1个月的胶原蛋白(马松三色染色)进行组织学评估。

 

结果显示,高密度参数显示VSS和POSAS评估得分显著改善(P值<.001)。柔韧度和缓解是改善最多的参数。组织病理学评估显示,在3个使用的参数中,胶原蛋白的平均面积百分比明显下降,高密度激光治疗的改善程度最高(P值<.001)。

综上,该研究结果表明,高密度二氧化碳点阵激光治疗在临床和组织病理学上对烧伤疤痕都有更好的改善。

 

原始出处:

 

Shereen Tawfic, et al., High- Versus Low-Density Fractional Laser in the Treatment of Hypertrophic Postburn Scars: A Randomized Clinical Trial. Dermatol Surg. 2020 Sep;46(9):e38-e44. doi: 10.1097/DSS.0000000000002293.

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    2022-07-27 hyf028
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    2021-08-22 oliver169
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    2021-08-22 HinsMax
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    2021-08-21 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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