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Psychot & Psychos:抗抑郁药物的又一个神奇作用

2017-10-18 佚名 medicalxpress

抗抑郁药通常是处方药,但他们的长期对身体的健康影响却存在争议。抗抑郁药破坏多个自适应过程的生化调节,有可能增加死亡率。然而,许多抗抑郁药也有抗血管的特性,可以有效地治疗心血管疾病。

抗抑郁药通常是处方药,但他们的长期对身体的健康影响却存在争议。抗抑郁药破坏多个自适应过程的生化调节,有可能增加死亡率。然而,许多抗抑郁药也有抗血管的特性,可以有效地治疗心血管疾病。

研究人员进行了一项数据分析,评估了抗抑郁药对一般人群和心血管病人样本的全因死亡率和心血管事件的影响。两位评审员独立评估PubMed,EMBASE和GoogleScholar的文章,介绍抑郁症和其他合并症的抗抑郁相关死亡率控制。从这些文章中,我们可以得到关于心血管事件、心血管疾病风险状况和抗抑郁类的信息。作者进行了混合效应数据分析,测试样品类型和抗抑郁药类作为全因死亡率和新的心血管事件的协调者。17项研究符合搜索标准。

结果显示,在一般人群中,抗抑郁药物的使用增加了死亡率和心血管事件的风险。在心血管病人中,抗抑郁剂的使用对风险没有明显的影响。抗抑郁药物也会降低死亡率,但血清素再吸收抑制剂与三环抗抑郁药没有明显区别。只有“其他抗抑郁药”与三环抗抑郁药有区别。当我们分析控制治疗前抑郁症的研究的结果时,死亡率风险估计增加了,这表明混淆因素可以排除。

作者得出结论认为抗抑郁药对普通人群有害,但对心血管病人的危害较小。

原始出处:

MM Maslej, BM Bolker, MJ Russell, et.al. The Mortality and Myocardial Effects of Antidepressants Are Moderated by Preexisting Cardiovascular Disease: A Meta-Analysis. Psychotherapy & Psychosomatics , 2017 , 86 (5) :268

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1722468, encodeId=495c1e2246828, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Tue Aug 28 10:37:00 CST 2018, time=2018-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255664, encodeId=6f9e25566462, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Tue Oct 24 20:31:14 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255375, encodeId=b86f2553e534, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Mon Oct 23 19:05:28 CST 2017, time=2017-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446688, encodeId=20d1144668851, content=<a href='/topic/show?id=38bf553405a' target=_blank style='color:#2F92EE;'>#抗抑郁药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55340, encryptionId=38bf553405a, topicName=抗抑郁药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4bd5278649, createdName=huhuaidong389, createdTime=Fri Oct 20 03:37:00 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492193, encodeId=19e9149219365, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Fri Oct 20 03:37:00 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254027, encodeId=221a25402e24, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4mzqK7XHyH86ToibWNdzamnZozW6yiceXFib4QHq1lCOia34v7bgwXUIH1Rdnoqia2y6ibLX156v1xmicZw/0, createdBy=15891613430, createdName=xuexin53, createdTime=Wed Oct 18 13:22:45 CST 2017, time=2017-10-18, status=1, ipAttribution=)]
    2018-08-28 wetgdt
  2. [GetPortalCommentsPageByObjectIdResponse(id=1722468, encodeId=495c1e2246828, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Tue Aug 28 10:37:00 CST 2018, time=2018-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255664, encodeId=6f9e25566462, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Tue Oct 24 20:31:14 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255375, encodeId=b86f2553e534, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKcmgibQ4oCrK7Z6f4CvMcs4k7QUGCkhopcGxvxaBfVciadECSIwaRVttllIOEKumpEaRrq5PoOUxow/0, createdBy=e3bb2081203, createdName=哈哈869, createdTime=Mon Oct 23 19:05:28 CST 2017, time=2017-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446688, encodeId=20d1144668851, content=<a href='/topic/show?id=38bf553405a' target=_blank style='color:#2F92EE;'>#抗抑郁药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55340, encryptionId=38bf553405a, topicName=抗抑郁药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4bd5278649, createdName=huhuaidong389, createdTime=Fri Oct 20 03:37:00 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492193, encodeId=19e9149219365, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Fri Oct 20 03:37:00 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254027, encodeId=221a25402e24, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4mzqK7XHyH86ToibWNdzamnZozW6yiceXFib4QHq1lCOia34v7bgwXUIH1Rdnoqia2y6ibLX156v1xmicZw/0, createdBy=15891613430, createdName=xuexin53, createdTime=Wed Oct 18 13:22:45 CST 2017, time=2017-10-18, status=1, ipAttribution=)]
    2017-10-24 哈哈869

    学了

    0

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    2017-10-23 哈哈869

    已阅

    0

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