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Neurology:心血管健康、遗传风险与痴呆风险的关系

2020-07-21 MedSci原创 MedSci原创

近日,神经病学领域权威杂志Neurology上发表了一篇研究文章,该研究观察到遗传风险和CVH均会增加痴呆风险。

近日,神经病学领域权威杂志Neurology上发表了一篇研究文章,该研究旨在明确理想的血管健康(CVH)和遗传风险对痴呆症风险的共同作用。

研究人员对1211名Framingham心脏研究(FHS)子代队列参与者根据常见遗传变异以及APOE e4基因型的遗传风险评分(GRS)衡量的遗传风险和美国心脏协会理想CVH指数对CVH进行了分类。研究人员使用多变量Cox比例风险回归模型评估了CVH、遗传风险和全因痴呆之间的关联,并进行了长达10年的随访(平均8.4年,共发生96例痴呆病例),并根据年龄、性别和教育进行调整。

研究人员观察到,与低GRS(<20%)相比,高GRS(>80%)与痴呆风险高2.6倍(风险比[HR]95%CI:1.23-5.29;p=0.012)相关。与不携带APOE e4等位基因相比,携带至少一个APOE e4等位基因与罹患痴呆症的风险增加2.3倍相关(HR的95%CI:1.49-3.53;p=0.0002),当所有三个成分都包括在模型中时,与不利的CVH相比,并且良好CVH使痴呆的风险降低了0.45(95%CI HR:0.20-1.01,p=0.0527)。研究人员没有观察到CVH和GRS(p=0.99)或APOE e4(p=0.16)之间的相互作用。

由此可见,该研究观察到遗传风险和CVH均会增加痴呆风险。

原始出处:

Gina M. Peloso.et al.Cardiovascular health, genetic risk, and risk of dementia in the Framingham Heart Study.Neurology.2020.https://n.neurology.org/content/early/2020/07/20/WNL.0000000000010306

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    2020-12-31 yinhl1978
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  5. [GetPortalCommentsPageByObjectIdResponse(id=2001086, encodeId=280520010865b, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Dec 31 02:12:16 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820409, encodeId=da25182040984, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Mon Jun 28 17:12:16 CST 2021, time=2021-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316752, encodeId=736d1316e5238, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Thu Jul 23 09:12:16 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361951, encodeId=566a136195152, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Jul 23 09:12:16 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803852, encodeId=6640803852f1, content=退行性疾病啊,治疗很困难。就如同衰老,正常的衰老也是一种广义上的病。, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47814065247, createdName=13b0e868m81暂无昵称, createdTime=Wed Jul 22 09:18:22 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803750, encodeId=afb4803e5065, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Tue Jul 21 22:03:27 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048635, encodeId=d27c10486355b, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Tue Jul 21 21:12:16 CST 2020, time=2020-07-21, status=1, ipAttribution=)]
    2020-07-22 13b0e868m81暂无昵称

    退行性疾病啊,治疗很困难。就如同衰老,正常的衰老也是一种广义上的病。

    0

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    2020-07-21 wxl882001

    了解一下

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2001086, encodeId=280520010865b, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Thu Dec 31 02:12:16 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820409, encodeId=da25182040984, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Mon Jun 28 17:12:16 CST 2021, time=2021-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316752, encodeId=736d1316e5238, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Thu Jul 23 09:12:16 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361951, encodeId=566a136195152, content=<a href='/topic/show?id=651f9521535' target=_blank style='color:#2F92EE;'>#遗传风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95215, encryptionId=651f9521535, topicName=遗传风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Jul 23 09:12:16 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803852, encodeId=6640803852f1, content=退行性疾病啊,治疗很困难。就如同衰老,正常的衰老也是一种广义上的病。, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47814065247, createdName=13b0e868m81暂无昵称, createdTime=Wed Jul 22 09:18:22 CST 2020, time=2020-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803750, encodeId=afb4803e5065, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Tue Jul 21 22:03:27 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048635, encodeId=d27c10486355b, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Tue Jul 21 21:12:16 CST 2020, time=2020-07-21, status=1, ipAttribution=)]
    2020-07-21 junJUN

    老年人痴呆何药可用??

    0

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近日,国际杂志 《Diabetic Med》上在线发表一项关于使用11个易感等位基因对普通日本人群中2型糖尿病发病率的遗传风险评分的预测性能的巢式病例对照研究,以评估遗传风险评分对一般日本人群中2型糖尿病发病率的预测能力。 这项前瞻性病例对照研结合在在日本公共卫生中心的前瞻性研究中,其中包括466名5年期间患有2型糖尿病的病例(病例)和1361名对照参与者,以及1463名现有糖尿病患者和14

NAT GENET:140万人大型研究发现318个II型糖尿病新风险位点

最近,研究人员通过对百万退伍军人计划(MVP)、DIAMANTE、日本生物库和其他研究中的228,499例患者和1,178,783例对照的多基因荟萃分析,调查了2型糖尿病(T2D)遗传易感性。

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