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高危人群筛选的利器——潜在类别聚类分析

2017-04-28 曹红艳/张岩波 BioMed数据坊

内容提要:机器学习按照训练数据是否有标记信息,可将学习任务分为监督学习(supervised learning)和非监督学习(unsupervised learning)两大类。其中,聚类分析是非监督学习的重要方法,潜在类别聚类分析(latent class cluster analysis,LCCA)可作为非监督学习方法,用于高危人群的筛选。LCCA假定异质性群体由多个总体混合而成,即存在一个潜

内容提要:机器学习按照训练数据是否有标记信息,可将学习任务分为监督学习(supervised learning)和非监督学习(unsupervised learning)两大类。其中,聚类分析是非监督学习的重要方法,潜在类别聚类分析(latent class cluster analysis,LCCA)可作为非监督学习方法,用于高危人群的筛选。LCCA假定异质性群体由多个总体混合而成,即存在一个潜在的分类变量,借助拟合优度评价指标确定最优模型,最后通过估计和比较后验概率进行分类,实现变量水平上的“降维”和个体水平上的“聚类”。LCCA所提取的潜在类别既能反映不同影响因素的综合效应,也能进一步考察不同类别人群分布特征。LCCA分析步骤以出生缺陷为例,依据可能的可观察的非检测影响因素,采用适当的评估方法筛选出高危人群,进而对高危人群做进一步的检测,既可以提高筛查效率,又能降低筛查成本。采用LCCA方法,研究出生缺陷危险特征的潜在类别及其分布特点,分为三个步骤。首先,从出生缺陷调查问卷中提取出生缺陷相关指示变量:母亲生育年龄、遗传因素、母亲既往病史、母亲饮食与叶酸食用情况、母亲孕期患病情况、

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    2017-05-17 184****9840

    看过了,谢谢分享。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1675038, encodeId=b2d416e50388a, content=<a href='/topic/show?id=7d321022504e' target=_blank style='color:#2F92EE;'>#高危人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102250, encryptionId=7d321022504e, topicName=高危人群)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e95727161035, createdName=Smile2689, createdTime=Thu Dec 14 15:30:00 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199367, encodeId=70b019936ea1, content=看过了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed May 17 23:05:34 CST 2017, time=2017-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197858, encodeId=ed2519e8588f, content=数理统计还有这个功能啊。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Sun May 14 07:57:40 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194336, encodeId=292a19433659, content=学习了,非常有用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAU2wVkTeANBK9R3rSMa9LcU72r7swR61YTJ7oZWL1MzhnJhRqMIsPZvCgHPwqmpYhDYKYK7dcwibS/0, createdBy=0cab1623974, createdName=hanchunhee, createdTime=Sat May 06 05:11:27 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584372, encodeId=682c15843e2e4, content=<a href='/topic/show?id=9bbee5948f0' target=_blank style='color:#2F92EE;'>#筛选#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75948, encryptionId=9bbee5948f0, topicName=筛选)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=39da17047364, createdName=ms6747015003810650, createdTime=Sun Apr 30 02:30:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191558, encodeId=630719155809, content=非常棒的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aadd1680584, createdName=蔬菜, createdTime=Fri Apr 28 19:38:50 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191528, encodeId=198a1915286a, content=感谢梅斯医学一直提供这么专业这么有价值的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Fri Apr 28 16:00:55 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191516, encodeId=bdf019151683, content=学习了,相当有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuADftdGTCtOFk6JIo8WtRPKSMvbibdWI9WNJl6EaqKuVbCvQPOp4FkibcpgZ57XROgfP3wzTEJE8ah/0, createdBy=63812044088, createdName=江南烟雨6212, createdTime=Fri Apr 28 15:33:08 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191452, encodeId=3340191452d0, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Fri Apr 28 11:32:16 CST 2017, time=2017-04-28, status=1, ipAttribution=)]
    2017-05-14 184****9840

    数理统计还有这个功能啊。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1675038, encodeId=b2d416e50388a, content=<a href='/topic/show?id=7d321022504e' target=_blank style='color:#2F92EE;'>#高危人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102250, encryptionId=7d321022504e, topicName=高危人群)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e95727161035, createdName=Smile2689, createdTime=Thu Dec 14 15:30:00 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199367, encodeId=70b019936ea1, content=看过了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed May 17 23:05:34 CST 2017, time=2017-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197858, encodeId=ed2519e8588f, content=数理统计还有这个功能啊。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Sun May 14 07:57:40 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194336, encodeId=292a19433659, content=学习了,非常有用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAU2wVkTeANBK9R3rSMa9LcU72r7swR61YTJ7oZWL1MzhnJhRqMIsPZvCgHPwqmpYhDYKYK7dcwibS/0, createdBy=0cab1623974, createdName=hanchunhee, createdTime=Sat May 06 05:11:27 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584372, encodeId=682c15843e2e4, content=<a href='/topic/show?id=9bbee5948f0' target=_blank style='color:#2F92EE;'>#筛选#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75948, encryptionId=9bbee5948f0, topicName=筛选)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=39da17047364, createdName=ms6747015003810650, createdTime=Sun Apr 30 02:30:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191558, encodeId=630719155809, content=非常棒的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aadd1680584, createdName=蔬菜, createdTime=Fri Apr 28 19:38:50 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191528, encodeId=198a1915286a, content=感谢梅斯医学一直提供这么专业这么有价值的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Fri Apr 28 16:00:55 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191516, encodeId=bdf019151683, content=学习了,相当有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuADftdGTCtOFk6JIo8WtRPKSMvbibdWI9WNJl6EaqKuVbCvQPOp4FkibcpgZ57XROgfP3wzTEJE8ah/0, createdBy=63812044088, createdName=江南烟雨6212, createdTime=Fri Apr 28 15:33:08 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191452, encodeId=3340191452d0, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Fri Apr 28 11:32:16 CST 2017, time=2017-04-28, status=1, ipAttribution=)]
    2017-05-06 hanchunhee

    学习了,非常有用。

    0

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    2017-04-28 蔬菜

    非常棒的内容

    0

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    2017-04-28 lovetcm

    感谢梅斯医学一直提供这么专业这么有价值的内容

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1675038, encodeId=b2d416e50388a, content=<a href='/topic/show?id=7d321022504e' target=_blank style='color:#2F92EE;'>#高危人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102250, encryptionId=7d321022504e, topicName=高危人群)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e95727161035, createdName=Smile2689, createdTime=Thu Dec 14 15:30:00 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199367, encodeId=70b019936ea1, content=看过了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Wed May 17 23:05:34 CST 2017, time=2017-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197858, encodeId=ed2519e8588f, content=数理统计还有这个功能啊。, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Sun May 14 07:57:40 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194336, encodeId=292a19433659, content=学习了,非常有用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAU2wVkTeANBK9R3rSMa9LcU72r7swR61YTJ7oZWL1MzhnJhRqMIsPZvCgHPwqmpYhDYKYK7dcwibS/0, createdBy=0cab1623974, createdName=hanchunhee, createdTime=Sat May 06 05:11:27 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584372, encodeId=682c15843e2e4, content=<a href='/topic/show?id=9bbee5948f0' target=_blank style='color:#2F92EE;'>#筛选#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75948, encryptionId=9bbee5948f0, topicName=筛选)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=39da17047364, createdName=ms6747015003810650, createdTime=Sun Apr 30 02:30:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191558, encodeId=630719155809, content=非常棒的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aadd1680584, createdName=蔬菜, createdTime=Fri Apr 28 19:38:50 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191528, encodeId=198a1915286a, content=感谢梅斯医学一直提供这么专业这么有价值的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Fri Apr 28 16:00:55 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191516, encodeId=bdf019151683, content=学习了,相当有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuADftdGTCtOFk6JIo8WtRPKSMvbibdWI9WNJl6EaqKuVbCvQPOp4FkibcpgZ57XROgfP3wzTEJE8ah/0, createdBy=63812044088, createdName=江南烟雨6212, createdTime=Fri Apr 28 15:33:08 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=191452, encodeId=3340191452d0, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Fri Apr 28 11:32:16 CST 2017, time=2017-04-28, status=1, ipAttribution=)]
    2017-04-28 江南烟雨6212

    学习了,相当有用

    0

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    2017-04-28 1dd8aa01m06(暂无匿称)

    学习了很好的内容

    0

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