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J Biomed Nanotechnol：双层微球与掺杂锶的聚磷酸钙骨架用于骨再生

2019-05-26 不详 网络

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设计和制备一种新型控释系统，用于两种药物的持续释放。在这项研究中，双层微球与锶掺杂的多磷酸钙（SCPP）支架结合，以促进骨再生和实现颅骨修复。通过静电纺丝制备结合四环素负载的海藻酸钠和基质金属蛋白酶-2（MMP-2）的壳聚糖的双层微球，其进一步粘附于SCPP支架。通过扫描电子显微镜观察微观结构的特征。研究了所得控释系统的负载效率和微球的最佳比例。此外，在体外检测细胞毒性和对成骨细胞增殖的影响和成骨

设计和制备一种新型控释系统，用于两种药物的持续释放。在这项研究中，双层微球与锶掺杂的多磷酸钙（SCPP）支架结合，以促进骨再生和实现颅骨修复。

通过静电纺丝制备结合四环素负载的海藻酸钠和基质金属蛋白酶-2（MMP-2）的壳聚糖的双层微球，其进一步粘附于SCPP支架。通过扫描电子显微镜观察微观结构的特征。研究了所得控释系统的负载效率和微球的最佳比例。此外，在体外检测细胞毒性和对成骨细胞增殖的影响和成骨相关因子的表达。此后，将具有控释系统的复合材料植入兔的颅骨缺损中，以评价其促进骨再生的性质。

结果表明，这种具有SCPP支架的新型控释系统和装有四环素和MMP-2的双层微球可能是一种很有前途的骨修复材料。

原始出处：

Ding Z, Yuan Q, et al., Double-Layer Microsphere Incorporated with Strontium Doped Calcium Polyphosphate Scaffold for Bone Regeneration. J Biomed Nanotechnol. 2019 Jun 1;15(6):1223-1231. doi: 10.1166/jbn.2019.2728.

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    2019-12-01 shock_melon

    #TEC#

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    2019-05-28 villahu

    #锶#

    0

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    2019-05-28 lsj630

    #骨再生#

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    2019-05-28 ms3994565386320060

    #Med#

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    2019-10-27 sunylz

    #Bio#

    0

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