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Diabetologia:改善口腔卫生与降低新发糖尿病的风险有关:一项基于全国人群的队列研究

2020-07-20 MedSci原创 MedSci原创

糖尿病是一个全球健康问题,炎症在糖尿病的发展中扮演着重要的角色。牙周病在普通人群中也很常见。由于牙周病和口腔卫生不良可引起短暂的菌血症和全身炎症,我们假设牙周病和口腔卫生指标与新发糖尿病的发生有关。

糖尿病是一个全球健康问题,炎症在糖尿病的发展中扮演着重要的角色。牙周病在普通人群中也很常见。由于牙周病和口腔卫生不良可引起短暂的菌血症和全身炎症,我们假设牙周病和口腔卫生指标与新发糖尿病的发生有关。

在这项研究中,我们分析了在2003年至2006年期间韩国国家健康保险系统健康筛查队列(NHIS-HEALS)收集的188,013名受试者的数据,这些受试者在人口统计学、既往病史、口腔卫生指标或实验室发现方面没有缺失数据。严格定义牙周疾病,并收集口腔卫生行为(刷牙次数、因故就诊次数、专业洗牙次数)作为自我报告的牙齿健康体检数据。牙科医生在口腔健康检查时,确定牙齿缺失的数目。根据ICD-10编码E10-E14定义新发糖尿病的发病率。该标准包括每年至少一项关于门诊就诊和任何降糖药物随处方记录入院的报销,或基于NHIS治疗的空腹血糖≥7 mmol/l。

研究结果显示,在纳入的研究对象中,有17.5%患有牙周病。在中位随访10年之后,31,545名受试者(事件发生率:16.1%,95% CI 15.9%,16.3%)出现糖尿病。在多变量模型中,在对人口统计学进行校正后,规律的运动,饮酒,吸烟状况,血管危险因素,恶性病史和实验室检查结果后,发现牙周疾病(HR 1.09、95%CI 1.07、1.12,p <0.001)和 缺失牙齿的数量(≥15齿)仍与新发糖尿病的发生呈正相关(HR 1.21,95%CI 1.09,1.33,p <0.001,p <0.001)。 频繁刷牙(≥3次/天)与新发糖尿病的发生呈负相关(HR 0.92,95%CI 0.89,0.95,p <0.001,p <0.001)。

研究结果表明,频繁刷牙可能是一种衰减因素,而牙周病的存在和缺牙数量的增加可能是新发糖尿病发生的增加因素。改善口腔卫生可能与降低新发糖尿病的发生风险有关。

原始出处:

Yoonkyung Chang,Ji Sung Lee,Improved oral hygiene is associated with decreased risk of new-onset diabetes: a nationwide population-based cohort study

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