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Crit Care:重症患者中心静脉压升高与死亡率增加和急性肾损伤相关

2020-03-06 xing.T MedSci原创

由此可见,CVP升高与重症监护病房成年重症患者死亡和AKI风险增加有关。

在重症成年患者中,中心静脉压(CVP)与死亡率和急性肾损伤(AKI)的关系仍不清楚。近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,研究人员进行了荟萃分析,以明确成年危重患者CVP升高是否与增加的死亡率和AKI有关。

研究人员对PubMed和Embase进行了检索,时间截止至2019年6月,以确定入住重症监护病房的成年危重患者CVP与死亡率和/或AKI之间关系的研究。研究人员使用随机效应模型计算了总的比值比(OR)和95%CI。

该分析纳入了十五项危重患者(主要是败血症)的队列研究。对于二分类数据,CVP升高与死亡(3项研究;969名参与者; OR为1.65;95%CI为1.19-2.29)和AKI(2项研究;689名参与者;OR为2.09; 95%CI为1.39-3.14)风险增加。对于连续数据,较高的CVP与较高的死亡(5项研究;7837名参与者; OR为1.10; 95%CI为1.03-1.17)和AKI(6项研究; 5446名参与者;OR为1.14;95%CI为1.06-1.23)风险相关。此外,CVP每增加1mmHg,AKI的几率就会增加6%(4项研究;5150名参与者; OR为1.06;95%CI为1.01-1.12)。对仅限于败血症患者开展进一步分析得出了一致的结果。

由此可见,CVP升高与重症监护病房成年重症患者死亡和AKI风险增加有关。

原始出处:

Chuan-Yu Chen.et al.Elevated central venous pressure is associated with increased mortality and acute kidney injury in critically ill patients: a meta-analysis.Critical Care.2020.https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-2770-5

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Baidu
map