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Med Sci Monit：β-受体阻滞剂1/2通过Wnt/β-Catenin途径加重糖尿病肾病的足细胞凋亡

2018-04-13 MedSci MedSci原创

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既往研究已显示β-抑制蛋白在糖尿病肾病进展中起关键作用。尽管如此，β-arrestins对足细胞凋亡调控的潜在机制却鲜有研究。本研究旨在阐明β-arrestin 1/2通过Wnt/β-连环蛋白通路对足细胞凋亡的调节。本研究通过质粒转染下调和上调β-arrestin 1/2的表达。Western blotting检测蛋白水平，RT-qPCR检测mRNA的表达。通过流式细胞术评估凋亡细胞。结果显示，在

既往研究已显示β-抑制蛋白在糖尿病肾病进展中起关键作用。尽管如此，β-arrestins对足细胞凋亡调控的潜在机制却鲜有研究。本研究旨在阐明β-arrestin 1/2通过Wnt/β-连环蛋白通路对足细胞凋亡的调节。

本研究通过质粒转染下调和上调β-arrestin 1/2的表达。Western blotting检测蛋白水平，RT-qPCR检测mRNA的表达。通过流式细胞术评估凋亡细胞。

结果显示，在高葡萄糖诱导的足细胞中，β-arrestin 1/2的表达水平上调。β-arrestin 1/2过度表达抑制了nephrin和podocin蛋白的表达。在高葡萄糖诱导的足细胞中，通过增加Bax、切割半胱天冬酶-3和p-p53的水平，上调β-arrestin 1/2促进足细胞凋亡和p53通路。流式细胞分析显示，与凋亡组相比，β-arrestin 1/2上调组凋亡细胞明显增多。β-arrestin 1/2上调组β-catenin的表达增加，提示Wnt/β-catenin信号通路被激活。Wnt/β-catenin通路抑制剂（Dkk1）明显抑制β-arrestin 1/2过表达和高葡萄糖诱导的细胞凋亡。

综上所述，这些结果提供了β-arrestin 1/2和Wnt/β-catenin通路在足细胞凋亡中的分子病理机制，为糖尿病肾病的治疗提供了新的思路，为今后研究糖尿病肾病和足细胞铺平了道路。

原始出处：

Yao Wang, Han Li, et al., β-Arrestin 1/2 Aggravates Podocyte Apoptosis of Diabetic Nephropathy via Wnt/β-Catenin Pathway. Med Sci Monit. 2018; 24: 1724–1732. doi:  10.12659/MSM.905642

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    2018-05-27 tulenzi

    #受体阻滞剂#

    0

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    2018-09-18 zhyy88

    #阻滞剂#

    0

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    2018-04-15 ms8538335253054589

    #细胞凋亡#

    0

  4. 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    2018-04-15 12498e87m43暂无昵称

    #β-受体阻滞剂#

    0

  5. 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    2018-04-15 zhwj

    #WNT#

    0

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    2018-04-15 ms3994565386320060

    #Med#

    0

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content=既往研究已显示β-抑制蛋白在糖尿病肾病进展中起关键作用.尽管如此.β-arrestins对足细胞凋亡调控的潜在机制却鲜有研究.本研究旨在阐明β-arrestin1/2通过Wnt/β-连环蛋白通路对足细胞凋亡的调节., beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Apr 14 05:00:29 CST 2018, time=2018-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305548, encodeId=a07c30554889, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat Apr 14 04:41:04 CST 2018, time=2018-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305511, encodeId=463c3055116e, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Apr 13 22:56:58 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2018-04-15 魅蓝青年

    标题能不能严谨一些...

    0

  8. 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    2018-04-14 有备才能无患

    既往研究已显示β-抑制蛋白在糖尿病肾病进展中起关键作用.尽管如此.β-arrestins对足细胞凋亡调控的潜在机制却鲜有研究.本研究旨在阐明β-arrestin1/2通过Wnt/β-连环蛋白通路对足细胞凋亡的调节.

    0

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createdBy=b8282062892, createdName=changjiu, createdTime=Sat Apr 14 04:41:04 CST 2018, time=2018-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305511, encodeId=463c3055116e, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Apr 13 22:56:58 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2018-04-14 changjiu

    学习一下谢谢

    0

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content=既往研究已显示β-抑制蛋白在糖尿病肾病进展中起关键作用.尽管如此.β-arrestins对足细胞凋亡调控的潜在机制却鲜有研究.本研究旨在阐明β-arrestin1/2通过Wnt/β-连环蛋白通路对足细胞凋亡的调节., beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Apr 14 05:00:29 CST 2018, time=2018-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305548, encodeId=a07c30554889, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, 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    2018-04-13 1e1b8538m79(暂无匿称)

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