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Biosci Rep：TGF-β通过抑制泛素 - 蛋白酶体途径阻止去神经支配诱导的骨形成减少并促进骨再生

2019-04-28 不详 网络

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转化生长因子β（TGF-β）可以作为多功能蛋白刺激成骨。本研究旨在探讨TGF-β是否可以预防去神经支配诱导的骨形成减少。使用重组人TGF-β1（rhTGF-β1）处理6周龄雄性小鼠。通过实时PCR在骨骼组织中测量骨形成，软骨内骨生长速率和成骨细胞标志物的基因表达。结果显示，RhTGF-β1治疗阻止去神经支配诱导的骨形成率，软骨内生长和Cbfa1/Runx2（Runt相关转录因子2），OC和ColI

转化生长因子β（TGF-β）可以作为多功能蛋白刺激成骨。本研究旨在探讨TGF-β是否可以预防去神经支配诱导的骨形成减少。

使用重组人TGF-β1（rhTGF-β1）处理6周龄雄性小鼠。通过实时PCR在骨骼组织中测量骨形成，软骨内骨生长速率和成骨细胞标志物的基因表达。

结果显示，RhTGF-β1治疗阻止去神经支配诱导的骨形成率，软骨内生长和Cbfa1/Runx2（Runt相关转录因子2），OC和ColIA1表达的降低。TGF-β1通过遍在蛋白-蛋白酶体通路部分抑制去神经诱导的小鼠松质骨中Cbfa1/Runx2的泛素化。

总之，TGF-β通过至少部分地抑制遍在蛋白-蛋白酶体通路来防止去神经支配诱导的骨形成减少并促进骨再生。

原始出处：

Yu Z, Li Y, et al., TGF-β Prevents the Denervation-induced Reduction of Bone Formation and Promotes the Bone Regeneration through Inhibiting Ubiquitin-proteosome Pathway. Biosci Rep. 2019 Apr 23. pii: BSR20190350. doi: 10.1042/BSR20190350.

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    2019-05-21 canlab

    #蛋白酶#

    0

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    2020-03-23 changhe713

    #TGF#

    0

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    2019-06-17 sunylz

    #Bio#

    0

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    2020-01-09 gds2009

    #蛋白酶体#

    0

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    2019-04-30 ms6980045490879608

    #TGF-β#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1945204, encodeId=529119452041a, content=<a href='/topic/show?id=249488e60fe' target=_blank style='color:#2F92EE;'>#蛋白酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88760, encryptionId=249488e60fe, topicName=蛋白酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=512d422, createdName=canlab, createdTime=Tue May 21 23:38:00 CST 2019, time=2019-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035885, encodeId=5b3c203588559, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Mon Mar 23 22:38:00 CST 2020, time=2020-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918652, encodeId=79e11918652a8, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon Jun 17 04:38:00 CST 2019, time=2019-06-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2042329, encodeId=ec532042329c7, content=<a href='/topic/show?id=702188e64cf' target=_blank style='color:#2F92EE;'>#蛋白酶体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88764, encryptionId=702188e64cf, topicName=蛋白酶体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f612331, createdName=gds2009, createdTime=Thu Jan 09 21:38:00 CST 2020, time=2020-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441372, encodeId=4db614413e2b8, content=<a href='/topic/show?id=58dd1e34591' target=_blank style='color:#2F92EE;'>#TGF-β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17345, encryptionId=58dd1e34591, topicName=TGF-β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=496f4824495, createdName=ms6980045490879608, createdTime=Tue Apr 30 09:38:00 CST 2019, time=2019-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472188, encodeId=15b714e2188ac, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Tue Apr 30 09:38:00 CST 2019, time=2019-04-30, status=1, ipAttribution=)]
    2019-04-30 lsj630

    #骨再生#

    0

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