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J Infect:COVID-19的过程中,呼吸道样本中的SARS-CoV-2病毒载量变化模式

2020-11-08 MedSci原创 MedSci原创

本文旨在总结SARS-CoV-2在感染过程中(包括任何无症状或症状前阶段)的检测模式和病毒载量,以及感染性持续时间的证据。

本文旨在总结SARS-CoV-2在感染过程中(包括任何无症状或症状前阶段)的检测模式和病毒载量,以及感染性持续时间的证据。
从2019年12月30日至2020年5月12日,我们在PubMed、欧洲PubMed Central和EMBASE中进行了系统的文献检索。
 
共确定了在17个国家进行的113项研究。来自上呼吸道样本的证据表明,SARS-CoV-2的病毒载量在症状发生前后或此后几天达到峰值,并在症状发生后两周左右变得不可检测;然而,来自痰液样本的病毒载量可能更高,峰值更晚,持续时间更长。有证据表明,粪便样本中的病毒检测时间较长,但临床意义不明确。没有发现明确测量感染性持续时间的研究;然而,患者在检测病毒的整个时间内可能并不具有传染性,因为病毒核糖核酸的存在可能不代表可传播的活病毒。
 
该结果表明,在COVID-19的过程中,呼吸道样本中的SARS-CoV-2病毒载量有一个相对一致的轨迹,但传染性的持续时间仍不确定。
 
原始出处:
Kieran A Walsh, Karen Jordan, et al., SARS-CoV-2 detection, viral load and infectivity over the course of an infection. J Infect. 2020 Sep;81(3):357-371.  doi: 10.1016/j.jinf.2020.06.067. 

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    2021-06-11 zhzhxiang
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    2021-07-23 hukaixun
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    2020-11-09 zhmscau
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    2020-11-09 小刀医生
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