Baidu
map

糖尿病

订阅

MedSci主页 / 所有栏目 / 糖尿病

Diabetologia：呼吸道感染与1型糖尿病自身免疫有关？

2017-10-23 MedSci MedSci原创

呼吸道感染1型糖尿病
关注

两项小型前瞻性研究报道呼吸道感染和胰岛自身免疫的发生有正相关。年轻糖尿病患者的环境决定因素研究（TEDDY）是对定期监测临床感染和胰岛自身抗体的1型糖尿病环境决定因素的最大的国际前瞻性国际队列研究。近日，国际杂志 《Diabetologia》上在线发表一项关于呼吸道感染与1型糖尿病自身免疫有关的TEDDY研究。目的是确认报告的呼吸道感染影响，并进一步描述与自身抗体血清学转换的时间关系。

两项小型前瞻性研究报道呼吸道感染和胰岛自身免疫的发生有正相关。年轻糖尿病患者的环境决定因素研究（TEDDY）是对定期监测临床感染和胰岛自身抗体的1型糖尿病环境决定因素的最大的国际前瞻性国际队列研究。近日，国际杂志 《Diabetologia》上在线发表一项关于呼吸道感染与1型糖尿病自身免疫有关的TEDDY研究。目的是确认报告的呼吸道感染影响，并进一步描述与自身抗体血清学转换的时间关系。 研究在2004-2009年间，对同时具有HLA基因型1型糖尿病增加风险的8676名的新生儿，从3个月开始随访至15年结束。在本研究中，在7869名儿童中评估3个月间隔至4岁父母报告的呼吸道感染与胰岛自身抗体的关系。采用时间依赖比例风险模型评估呼吸系统感染的时间如何与持续确认的胰岛细胞免疫有关，并将此定义为胰岛素自身抗体阳性，GAD和/或胰岛素抗原-2的自身抗体阳性，经连续两次随访并经两个以上参考实验室确认。 研究共记录了87,327例家长报告的呼吸道感染事件，这些儿童进行胰岛自身免疫研究监测，454例患儿进行血清转换。9个月内发生呼吸道感染的数量与随后的自身免疫风险相关（p  <0.00

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1638110, encodeId=bea0163811075, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Mar 27 13:23:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760267, encodeId=afec1e602672b, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Oct 05 05:23:00 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282429, encodeId=9568128242961, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Wed Oct 25 13:23:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255605, encodeId=a6b625560589, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Tue Oct 24 12:25:14 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255457, encodeId=a59725545e55, content=不错的啊文章值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon Oct 23 22:49:13 CST 2017, time=2017-10-23, status=1, ipAttribution=)]
    2018-03-27 ms9608593228839890

    #DIA#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1638110, encodeId=bea0163811075, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Mar 27 13:23:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760267, encodeId=afec1e602672b, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Oct 05 05:23:00 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282429, encodeId=9568128242961, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Wed Oct 25 13:23:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255605, encodeId=a6b625560589, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Tue Oct 24 12:25:14 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255457, encodeId=a59725545e55, content=不错的啊文章值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon Oct 23 22:49:13 CST 2017, time=2017-10-23, status=1, ipAttribution=)]
    2018-10-05 ms5439512287675881

    #BET#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1638110, encodeId=bea0163811075, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Mar 27 13:23:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760267, encodeId=afec1e602672b, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Oct 05 05:23:00 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282429, encodeId=9568128242961, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Wed Oct 25 13:23:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255605, encodeId=a6b625560589, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Tue Oct 24 12:25:14 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255457, encodeId=a59725545e55, content=不错的啊文章值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon Oct 23 22:49:13 CST 2017, time=2017-10-23, status=1, ipAttribution=)]
    2017-10-25 zhmscau

    #呼吸道#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1638110, encodeId=bea0163811075, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Mar 27 13:23:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760267, encodeId=afec1e602672b, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Oct 05 05:23:00 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282429, encodeId=9568128242961, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Wed Oct 25 13:23:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255605, encodeId=a6b625560589, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Tue Oct 24 12:25:14 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255457, encodeId=a59725545e55, content=不错的啊文章值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon Oct 23 22:49:13 CST 2017, time=2017-10-23, status=1, ipAttribution=)]
    2017-10-24 llaq

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1638110, encodeId=bea0163811075, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Mar 27 13:23:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760267, encodeId=afec1e602672b, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Fri Oct 05 05:23:00 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282429, encodeId=9568128242961, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Wed Oct 25 13:23:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255605, encodeId=a6b625560589, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/28/37a322fa6e8be63db9e493f1c35a800a.jpg, createdBy=e5461842402, createdName=llaq, createdTime=Tue Oct 24 12:25:14 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255457, encodeId=a59725545e55, content=不错的啊文章值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon Oct 23 22:49:13 CST 2017, time=2017-10-23, status=1, ipAttribution=)]
    2017-10-23 1e1b8538m79(暂无匿称)

    不错的啊文章值得一读

    0

相关资讯

遇到呼吸道传染病，口罩不够怎么办？听APIC怎么说

医疗机构有多种呼吸防护装置可供使用，包括重复使用的和一次性的呼吸器，以及各种不同类型的口罩。呼吸防护是呼吸道传染病灾害发生时预防感染传播的唯一策略。

BMJ：减少抗生素处方对于呼吸道感染的安全性

该研究的目的是确定肺炎，扁桃体周围脓肿，乳突炎，脓胸，脑膜炎，颅内脓肿，以及勒米埃综合征的发病率是否较高，可以开较少的抗生素处方来治疗自限性呼吸道感染（RTIs）。原始出处：Martin C Gulliford,Michael V Moore,Paul Little,et al.Safety of reduced antibiotic prescribing for self limiting r

梳理维生素D功能研究新近进展

洒在脸上的阳光着实让人感觉到惬意，而且它还能带来有益于健康的效果，中波紫外线能够帮助我们合成维生素D。

CIRC J：血清维生素D与普通日本人群全因死亡及特定原因死亡之间的关系--久山研究

目前很少有研究调查一般亚洲人群血清维生素D水平与死亡率之间的关系。近期来自日本的学者发表研究性论着于circulation journal。研究者检测血清1，25-二羟维生素D（1，25（OH）2D）水平与全因死亡及特定原因死亡之间的关系。研究纳入2002 - 2012年，即平均9.5年随访时间中，3，292例年龄≥40岁的社区住院日本人。随着血清1，25（OH）2D水平降低，全因死亡的多变量调整

Intern Med J：呼吸道感染后一周内心梗风险增17倍

流感、肺炎、支气管炎……呼吸道感染是最常见的疾病了，而近期悉尼大学学者进行的研究显示，呼吸道感染“后劲儿”大，1周内可增加17倍的心梗风险，尤其是感染后第7日风险最高，而且此后1个月虽然风险逐渐降低但风险仍高。

Eur Respir J：IFI27作为一种新的免疫标志物可以区分流感病毒和细菌性呼吸道感染！

由此可见，IFI27代表了在基因组实验在临床应用上克服转化障碍的重要一步；它的实现可以改善呼吸系统感染的诊断和治疗。

Baidu
map
Baidu
map
Baidu
map