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Br J Nutr:孕妇膳食叶酸摄入量与叶酸补充量与小于胎龄儿的关系

2019-08-28 不详 网络

母亲叶酸摄入量对小于胎龄儿(SGA)分娩的影响尚无定论。本研究旨在利用中国西北陕西省横断面研究数据,研究饮食和补充剂中母体叶酸摄入量与SGA分娩风险之间的关系。共纳入7307名分娩后12个月内(中位数3;第10-90百分位数0-7)的女性。采用两级模型检查叶酸(膳食叶酸,补充叶酸和总叶酸)摄入与SGA分娩和出生体重Z评分的风险之间的关联,控制在有向无环图中确定的最小混杂因子集。结果显示,孕早期补充


母亲叶酸摄入量对小于胎龄儿(SGA)分娩的影响尚无定论。本研究旨在利用中国西北陕西省横断面研究数据,研究饮食和补充剂中母体叶酸摄入量与SGA分娩风险之间的关系。

共纳入7307名分娩后12个月内(中位数3;第10-90百分位数0-7)的女性。采用两级模型检查叶酸(膳食叶酸,补充叶酸和总叶酸)摄入与SGA分娩和出生体重Z评分的风险之间的关联,控制在有向无环图中确定的最小混杂因子集。

结果显示,孕早期补充叶酸摄入量与SGA分娩风险呈负相关(≤60d V. 不使用:OR0.80; 95%CI0.66,0.96;> 60 d V. 不使用:OR 0.78; 95%CI 0.65,0.94; Ptrend =0.010;每增加10 d:OR 0.97; 95%CI 0.95,0.99)。怀孕期间总叶酸摄入量较高与SGA分娩风险降低有关(最高三分位数V. 最低三分位数:OR 0.77; 95%CI 0.64,0.94; P趋势 =0.010;对数变换值每增加一单位:OR 0.81; 95%CI 0.69,0.95)。对于出生体重Z评分观察到类似的模式。

我们的研究表明,妊娠早期补充叶酸和怀孕期间总叶酸摄入量增加与SGA分娩风险降低有关。

原始出处:

Li S, Liu D, et al., The association of maternal dietary folate intake and folic acid supplementation with small-for-gestational-age births: a cross-sectional study in Northwest China. Br J Nutr. 2019 Aug 5:1-9. doi: 10.1017/S0007114519001272.

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    2020-01-20 lmm397
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    2019-08-30 heli0118
  6. [GetPortalCommentsPageByObjectIdResponse(id=1860651, encodeId=d13d1860651a8, content=<a href='/topic/show?id=830b5693631' target=_blank style='color:#2F92EE;'>#摄入量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56936, encryptionId=830b5693631, topicName=摄入量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Mon Jan 20 00:41:00 CST 2020, time=2020-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740317, encodeId=7e7a1e40317c3, content=<a href='/topic/show?id=f9f383688d0' target=_blank style='color:#2F92EE;'>#胎龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83688, encryptionId=f9f383688d0, topicName=胎龄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f53c34728820, createdName=ms8538335253054589, createdTime=Sun Jun 28 22:41:00 CST 2020, time=2020-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809494, encodeId=d08618094940a, content=<a href='/topic/show?id=c9f18368966' target=_blank style='color:#2F92EE;'>#胎龄儿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83689, encryptionId=c9f18368966, topicName=胎龄儿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=82ba2500166, createdName=ms1467340776200723, createdTime=Tue Jun 30 13:41:00 CST 2020, time=2020-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1756729, encodeId=822f1e5672929, content=<a href='/topic/show?id=20f846859f8' target=_blank style='color:#2F92EE;'>#小于胎龄儿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46859, encryptionId=20f846859f8, topicName=小于胎龄儿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=887337209203, createdName=ms3117646317107274, createdTime=Thu Apr 09 19:41:00 CST 2020, time=2020-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350410, encodeId=c6621350410df, content=<a href='/topic/show?id=224a85904ad' target=_blank style='color:#2F92EE;'>#膳食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85904, encryptionId=224a85904ad, topicName=膳食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Fri Aug 30 13:41:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371933, encodeId=083a3e193313, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Aug 28 22:55:54 CST 2019, time=2019-08-28, status=1, ipAttribution=)]
    2019-08-28 天地飞扬

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