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Diabetologia：与2型糖尿病，空腹血糖和HbA 1c水平相关的DNA甲基化标记物？

2018-04-24 MedSci MedSci原创

2型糖尿病
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近日，国际杂志 《Diabetologia》上在线发表一项关于与2型糖尿病，空腹血糖和HbA 1c水平相关的DNA甲基化标记物的系统综述研究。 在2型糖尿病的病因学中，表观遗传机制可能发挥重要作用。最近的表观遗传关联研究（EWASs）确定了与2型糖尿病，空腹血糖和HbA 1c水平相关的几种DNA甲基化标记。在这里，研究人员提供了这些研究的系统评价，并尝试在生命线研究的病例对照样本中复制EWA

近日，国际杂志 《Diabetologia》上在线发表一项关于与2型糖尿病，空腹血糖和HbA 1c水平相关的DNA甲基化标记物的系统综述研究。 在2型糖尿病的病因学中，表观遗传机制可能发挥重要作用。最近的表观遗传关联研究（EWASs）确定了与2型糖尿病，空腹血糖和HbA 1c水平相关的几种DNA甲基化标记。在这里，研究人员提供了这些研究的系统评价，并尝试在生命线研究的病例对照样本中复制EWASs中的最显著关联CpG位点（CpGs）。 研究人员在PubMed和EMBASE中对EWASs进行了系统的文献检索，以调查DNA甲基化与2型糖尿病和/或血糖特征之间的关联并审核了检索结果。为了复制目的，研究人员使用研究特异性Bonferroni校正的显著性阈值，从15个EWASs中选择100个在外周血，胰腺，脂肪组织和肝脏中鉴定的独特CpG。使用100名2型糖尿病个体和生命线研究的100名对照个体的全血中的甲基化数据（Illumina 450K阵列）。采用多元线性模型分析特定CpG与2型糖尿病和血糖特征的关联。 选择从血液中鉴定的52个CpGs中用于复制研究，在生命线样本中15个CpGs与2型糖尿病

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    2018-10-20 ms5439512287675881

    #BET#

    0

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    2018-12-31 ms9608593228839890

    #DIA#

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    2018-12-06 wjywjy

    #标记物#

    0

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    2018-10-15 Smile2680

    #HbA#

    0

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    2018-04-26 手留余香

    #空腹血糖#

    0

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