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NAT MED:“人猪合体”可以帮助恢复损伤的人类肺部

2020-07-15 MedSci原创 MedSci原创

等待肺移植的患者面临着较高的等待名单死亡率,因为损伤使得大多数供体肺的变得不可用。

等待肺移植的患者面临着较高的等待名单死亡率,因为损伤使得大多数供体肺的变得不可用。

尽管体外肺灌注(EVLP)能够恢复边际质量的供体肺,但将常温支持延长到6小时以上一直具有挑战性。

最近,研究人员证明,无法进行肺移植的急性损伤的人类肺部,包括在EVLP上未能恢复的肺部,可以通过外植体人类肺部和约克夏猪之间的全血交叉循环来恢复。

这个异种基因平台为外植体人肺提供了一个支持性的生理环境和系统调节,导致24小时常温支持后的功能和组织学恢复。

该研究结果表明,交叉循环可以作为临床EVLP的补充方法,以恢复受伤的供体肺,也可作为免疫调节和先进的器官生物工程的转化研究平台。

 

原始出处:

Ahmed E. Hozain et al. Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs, NATURE MEDICINE (2020).

 

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    2020-08-21 liye789132251
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    2020-07-17 muzishouyi
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