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Stroke:头痛早期,脑CT排除蛛网膜下腔出血敏感性较高

2016-07-25 phylis 译 MedSci原创

背景:新的证据表明早期脑部电脑断层扫描(CT)高灵敏度带来的问题,即CT诊断阴性后,必须进行腰椎穿刺诊断自发性蛛网膜下腔出血的(SAH)。研究者旨在确定头痛开始6小时内脑CT排除SAH的敏感性。方法:对Ovid MEDLINE, Ovid EMBASE, Web of Science和Scopus进行全面的文献检索,研究者进行了一项荟萃分析。纳入自发性蛛网膜下腔出血史的患者,在症状开始6小时内使用

背景:新的证据表明早期脑部电脑断层扫描(CT)高灵敏度带来的问题,即CT诊断阴性后,必须进行腰椎穿刺诊断自发性蛛网膜下腔出血的(SAH)。研究者旨在确定头痛开始6小时内脑CT排除SAH的敏感性。

方法:对Ovid MEDLINE, Ovid EMBASE, Web of Science和Scopus进行全面的文献检索,研究者进行了一项荟萃分析。纳入自发性蛛网膜下腔出血史的患者,在症状开始6小时内使用新一代的多排螺旋CT扫描的原始研究。研究以系统综述和荟萃分析作为优先报告项目(PRISMA)。

结果:总共对882个论文进行了审查,5篇论文符合纳入标准,包括8907例患者。6小时内脑CT未显示蛛网膜下腔出血(发生率1.46/1000)。CT的总敏感性为0.987(95%CI,0.971-0.994),特异性为0.999(95%CI,0.993-1.0)。阴性CT总似然比(likelihood Ratio, LR)为0.010(95%CI,0.003-0.034)。

结论:出现剧烈头痛和神经系统检查正常的患者,头痛6小时内脑CT排除动脉瘤性蛛网膜下腔出血是极其敏感的。

原始出处:

Dubosh NM, Bellolio MF, et al. Sensitivity of Early Brain Computed Tomography to Exclude Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis. Stroke. 2016 Mar


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  2. [GetPortalCommentsPageByObjectIdResponse(id=1654423, encodeId=68351654423f7, content=<a href='/topic/show?id=5ab788e81d3' target=_blank style='color:#2F92EE;'>#蛛网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88781, encryptionId=5ab788e81d3, topicName=蛛网膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=396c24497244, createdName=aliceclz, createdTime=Tue Nov 01 13:50:00 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810324, encodeId=09e81810324c2, content=<a href='/topic/show?id=aaed84691e7' target=_blank style='color:#2F92EE;'>#脑CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84691, encryptionId=aaed84691e7, topicName=脑CT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c5e117, createdName=lujian, createdTime=Tue Jul 26 14:50:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145349, encodeId=e317145349c6, content=好文值得点赞!继续关注学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=196, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:15:38 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388325, encodeId=023a1388325d9, content=<a href='/topic/show?id=7ef25e5346b' target=_blank style='color:#2F92EE;'>#敏感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57534, encryptionId=7ef25e5346b, topicName=敏感性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJnkE6UvGFfMS41qV0RicWvVTTeLMicqibeZH5GqO4YhNicyl1Y9jFhylIUBn9ntPYy9jhk5hrfic5cRYw/132, createdBy=5f822500020, createdName=ms5236388012055669, createdTime=Wed Jul 27 14:50:00 CST 2016, time=2016-07-27, status=1, ipAttribution=)]
    2016-07-26 lujian
  3. [GetPortalCommentsPageByObjectIdResponse(id=1654423, encodeId=68351654423f7, content=<a href='/topic/show?id=5ab788e81d3' target=_blank style='color:#2F92EE;'>#蛛网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88781, encryptionId=5ab788e81d3, topicName=蛛网膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=396c24497244, createdName=aliceclz, createdTime=Tue Nov 01 13:50:00 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810324, encodeId=09e81810324c2, content=<a href='/topic/show?id=aaed84691e7' target=_blank style='color:#2F92EE;'>#脑CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84691, encryptionId=aaed84691e7, topicName=脑CT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c5e117, createdName=lujian, createdTime=Tue Jul 26 14:50:00 CST 2016, time=2016-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145349, encodeId=e317145349c6, content=好文值得点赞!继续关注学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=196, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:15:38 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388325, encodeId=023a1388325d9, content=<a href='/topic/show?id=7ef25e5346b' target=_blank style='color:#2F92EE;'>#敏感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57534, encryptionId=7ef25e5346b, topicName=敏感性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJnkE6UvGFfMS41qV0RicWvVTTeLMicqibeZH5GqO4YhNicyl1Y9jFhylIUBn9ntPYy9jhk5hrfic5cRYw/132, createdBy=5f822500020, createdName=ms5236388012055669, createdTime=Wed Jul 27 14:50:00 CST 2016, time=2016-07-27, status=1, ipAttribution=)]
    2016-10-11 ylzr123

    好文值得点赞!继续关注学习。

    0

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