FASEB J：骨骼细胞YAP和TAZ共同促进骨发育

2018-02-10 MedSci MedSci原创

同源转录共激活物Yes相关蛋白（YAP）和转录共激活因子PDZ结合基序（TAZ）在骨中的功能是有争议的。既往研究已发现二者均可独立在体外促进或抑制成骨作用，但是关于二者共同作用的效果却尚未可知。本研究中，研究人员使用来源于骨骼谱系细胞的Osterix-Cre细胞，YAP/TAZ的缺失导致成骨不全症样表型，严重程度取决于等位基因量和更高的TAZ VS. YAP消除的表型表现性。YAP/TAZ缺失通过

同源转录共激活物Yes相关蛋白（YAP）和转录共激活因子PDZ结合基序（TAZ）在骨中的功能是有争议的。既往研究已发现二者均可独立在体外促进或抑制成骨作用，但是关于二者共同作用的效果却尚未可知。

本研究中，研究人员使用来源于骨骼谱系细胞的Osterix-Cre细胞，YAP/TAZ的缺失导致成骨不全症样表型，严重程度取决于等位基因量和更高的TAZ VS. YAP消除的表型表现性。YAP/TAZ缺失通过减少胶原蛋白含量和组织降低了骨应激并降低了内在骨成分的特性。这些结构和材料缺陷产生自发性骨折，尤其是在纯合TAZ缺失的小鼠中，并在双纯合子敲除中引起新生儿死亡。

在细胞水平体内，YAP/TAZ敲除减少成骨细胞活性和增加破骨细胞活性，以等位基因剂量依赖性方式，损害骨应计和重塑。YAP/TAZ缺失和与转录因子TEAD相互作用的小分子抑制YAP/TAZ可以在体内和体外降低成骨和胶原相关基因的表达。

综上所述，该研究结果表明，YAP和TAZ通过调节成骨细胞活性、基质质量和破骨细胞重塑来组合促进骨发育。

原始出处：

Kegelman CD, Mason DE, et al., Skeletal cell YAP and TAZ combinatorially promote bone development. FASEB J. 2018 Jan 10:fj201700872R. doi: 10.1096/fj.201700872R.

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插入图片

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2018-09-29 gujh

#YAP#

30 0
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2018-12-03 gracezdd

#FAS#

25 0
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2018-07-21 12498e5fm22(暂无昵称)

#AZ#

34 0
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2018-02-12 neurowu

#发育#

28 0
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2018-02-11 1e1b8538m79(暂无匿称)

不错的文章值得拥有

44 0
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2018-02-11 海之蓝

学习

38 0
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2018-02-10 changjiu

学习一下谢谢

42 0
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2018-02-10 131****1460

学习了受益匪浅

34 0
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2018-02-10 医者仁心5538

学习了

49 0

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