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Circulation:不同链球菌菌血症时感染性心内膜炎的发病率

2020-08-28 MedSci原创 MedSci原创

链球菌常引起感染性心内膜炎(IE),但由不同种类的链球菌引起的血液感染(BSIs)患者的IE患病率尚不明确。本研究旨在在菌种水平上调查链球菌BSI患者的IE发生率。

链球菌常引起感染性心内膜炎(IE),但由不同种类的链球菌引起的血液感染(BSIs)患者的IE患病率尚不明确。本研究旨在在菌种水平上调查链球菌BSI患者的IE发生率。

研究人员对2008年-2017年期间在丹麦首都地区的所有链球菌BSIs患者。并将数据与丹麦全国的登记资料交叉,以确定与同期IE的住院情况。在多变量logistic回归分析中,研究人员还调查了根据链球菌种属的IE风险。

在6506例链球菌BSI患者(平均68.1岁,52.8%的男性)中,IE的发病率为7.1%(95% CI 6.5-7.8)。肺炎链球菌和化脓性链球菌的IE发病率最低(1.2%和1.9%)。血链球菌、唾液链球菌和无乳链球菌的IE发病率居中(4.8%、5.8%和9.1%)。IE发病率最高的链球菌为轻型/口腔链球菌(19.4%)、解没食子酸链球菌(30.2%)、咽峡炎链球菌(34.6%)、戈登链球菌(44.2%)和变形链球菌(47.9%)。
在以肺炎链球菌为参考的多变量分析中,所有类型链球菌(除了化脓性链球菌)均与IE风险明显增加有关,风险比最高的依次是解没食子酸链球菌(OR 31.0) 、轻型/口腔链球菌(31.0)、咽峡炎链球菌(59.1)、戈登链球菌(80.8)和变形链球菌(81.3)。

IE在链球菌菌血症中的发生率具有菌种依赖性,由变形链球菌、戈登链球菌、血链球菌、解没食子酸链球菌和轻型/口腔链球菌引起的菌血症时感染性心内膜炎的发病率最高。

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    2022-07-18 Doctoryangbai

    学习了

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