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JAHA:白细胞介素13受体α1在心肌稳态和心力衰竭中的新作用!

2017-05-27 xing.T MedSci原创

由此可见,在人类和小鼠的研究结果首次表明白细胞介素13受体α1在心肌稳态和心力衰竭中的作用,这为心脏病的治疗提供了新的治疗靶点。

免疫系统在心肌稳态和损伤反应中起着举足轻重的作用。白细胞介素4和白细胞介素13是2型抗炎细胞因子,其信号是通过常见的白细胞介素13受体α1链和2型白细胞介素4受体所介导。然而,白细胞介素13受体α1在心脏中的作用尚不清楚。近日,心血管疾病领域权威杂志JAHA上针对这一问题发表了一篇研究文章。

研究人员分析了来自于人类供体(n=136)和终末期心力衰竭患者(n=177)的心肌样本。研究人员发现白细胞介素13受体α1存在于心肌细胞中,并与互补的2型白细胞介素4受体链Il4ra一致,在心衰患者的心脏中显着下调。

接下来,研究人员发现Il13ra1缺陷小鼠出现了严重的心肌功能障碍并且不能同步化,相比于野生型小鼠(左室射血分数为29.7±9.9 vs. 45±8;P=0.004,左室舒张末直径为4.2±0.2 vs. 3.92±0.3;P=0.03)。小鼠心脏的生物信息学分析表明白细胞介素13受体α1在心脏中调节重要信号通路,而不是免疫系统,如细胞外基质(归一化富集得分为1.90;错误发现率q=0.005)和糖代谢(归一化富集得分为2.36;错误发现率q=0)。在正常压力和压力负荷超载的情况下,Il13ra1缺失与减少的胶原沉积有关。

由此可见,在人类和小鼠的研究结果首次表明白细胞介素13受体α1在心肌稳态和心力衰竭中的作用,这为心脏病的治疗提供了新的治疗靶点。

原始出处:

Uri Amit,et al. New Role for Interleukin‐13 Receptor α1 in Myocardial Homeostasis and Heart Failure.JAHA.2017. https://doi.org/10.1161/JAHA.116.005108

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    2017-12-03 changfy
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createdName=zhaohui6731, createdTime=Mon May 29 14:15:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203911, encodeId=acac20391122, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6XtWFkdce8Hiav6b8ntyFxhFAddYYlLh0NR1N9E3H1lYgrsbtG2lc5Z8Ht8BJh1t45TIN8fCtNbd9Pib5445babo/0, createdBy=10472062033, createdName=芳哥, createdTime=Mon May 29 08:05:55 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203839, encodeId=f0c1203839c7, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon May 29 07:06:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203701, encodeId=4e38203e015a, content=感谢分享一下!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Sun May 28 21:57:38 CST 2017, time=2017-05-28, status=1, ipAttribution=)]
    2017-06-07 laoli

    学习了,谢谢分享!

    0

  5. 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    2017-05-31 尹玉伟

    厉害厉害……学习了

    0

  6. 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createdName=zhaohui6731, createdTime=Mon May 29 14:15:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203911, encodeId=acac20391122, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6XtWFkdce8Hiav6b8ntyFxhFAddYYlLh0NR1N9E3H1lYgrsbtG2lc5Z8Ht8BJh1t45TIN8fCtNbd9Pib5445babo/0, createdBy=10472062033, createdName=芳哥, createdTime=Mon May 29 08:05:55 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203839, encodeId=f0c1203839c7, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon May 29 07:06:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203701, encodeId=4e38203e015a, content=感谢分享一下!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Sun May 28 21:57:38 CST 2017, time=2017-05-28, status=1, ipAttribution=)]
    2017-05-29 zhaohui6731
  8. [GetPortalCommentsPageByObjectIdResponse(id=1646706, encodeId=14911646e06bc, content=<a href='/topic/show?id=4478e5315e1' target=_blank style='color:#2F92EE;'>#稳态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75315, encryptionId=4478e5315e1, topicName=稳态)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3ebc23344390, createdName=changfy, createdTime=Sun Dec 03 16:15:00 CST 2017, time=2017-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800094, encodeId=309218000948e, content=<a href='/topic/show?id=8665e17311b' target=_blank style='color:#2F92EE;'>#白细胞介素1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71731, encryptionId=8665e17311b, topicName=白细胞介素1)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKeia4TJeMGvEH3wKKIBNjuHuIic1HDNOB10j4tCd3nbylxkxm6HSMfEaKkSu6OZOak4uZv7UVicsWEg/132, createdBy=bc9a2500116, createdName=zywlvao, createdTime=Sun Mar 25 17:15:00 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1924136, encodeId=3bd319241367b, content=<a href='/topic/show?id=794d5803930' target=_blank style='color:#2F92EE;'>#新作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58039, encryptionId=794d5803930, topicName=新作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Mon Oct 09 11:15:00 CST 2017, time=2017-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207570, encodeId=23ca20e570ad, content=学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Wed Jun 07 07:37:56 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204742, encodeId=5953204e429e, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Wed May 31 08:58:58 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620552, encodeId=059a1620552fe, content=<a href='/topic/show?id=25a4e1714f0' target=_blank style='color:#2F92EE;'>#白细胞介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71714, encryptionId=25a4e1714f0, topicName=白细胞介素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1dc20143475, createdName=yxch43, createdTime=Mon May 29 14:15:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267459, encodeId=1517126e459e0, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Mon May 29 14:15:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203911, encodeId=acac20391122, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6XtWFkdce8Hiav6b8ntyFxhFAddYYlLh0NR1N9E3H1lYgrsbtG2lc5Z8Ht8BJh1t45TIN8fCtNbd9Pib5445babo/0, createdBy=10472062033, createdName=芳哥, createdTime=Mon May 29 08:05:55 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203839, encodeId=f0c1203839c7, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon May 29 07:06:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203701, encodeId=4e38203e015a, content=感谢分享一下!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Sun May 28 21:57:38 CST 2017, time=2017-05-28, status=1, ipAttribution=)]
    2017-05-29 芳哥

    谢谢分享

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1646706, encodeId=14911646e06bc, content=<a href='/topic/show?id=4478e5315e1' target=_blank style='color:#2F92EE;'>#稳态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75315, encryptionId=4478e5315e1, topicName=稳态)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3ebc23344390, createdName=changfy, createdTime=Sun Dec 03 16:15:00 CST 2017, time=2017-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800094, encodeId=309218000948e, content=<a href='/topic/show?id=8665e17311b' target=_blank style='color:#2F92EE;'>#白细胞介素1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71731, encryptionId=8665e17311b, topicName=白细胞介素1)], attachment=null, authenticateStatus=null, 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likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Wed Jun 07 07:37:56 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204742, encodeId=5953204e429e, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Wed May 31 08:58:58 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620552, encodeId=059a1620552fe, content=<a href='/topic/show?id=25a4e1714f0' target=_blank style='color:#2F92EE;'>#白细胞介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71714, encryptionId=25a4e1714f0, topicName=白细胞介素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1dc20143475, createdName=yxch43, createdTime=Mon May 29 14:15:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267459, encodeId=1517126e459e0, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Mon May 29 14:15:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203911, encodeId=acac20391122, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6XtWFkdce8Hiav6b8ntyFxhFAddYYlLh0NR1N9E3H1lYgrsbtG2lc5Z8Ht8BJh1t45TIN8fCtNbd9Pib5445babo/0, createdBy=10472062033, createdName=芳哥, createdTime=Mon May 29 08:05:55 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203839, encodeId=f0c1203839c7, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon May 29 07:06:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203701, encodeId=4e38203e015a, content=感谢分享一下!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Sun May 28 21:57:38 CST 2017, time=2017-05-28, status=1, ipAttribution=)]
    2017-05-29 130****4638

    学习了谢谢分享。

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1646706, encodeId=14911646e06bc, content=<a href='/topic/show?id=4478e5315e1' target=_blank style='color:#2F92EE;'>#稳态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75315, encryptionId=4478e5315e1, topicName=稳态)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3ebc23344390, createdName=changfy, createdTime=Sun Dec 03 16:15:00 CST 2017, time=2017-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800094, encodeId=309218000948e, content=<a href='/topic/show?id=8665e17311b' target=_blank style='color:#2F92EE;'>#白细胞介素1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71731, encryptionId=8665e17311b, topicName=白细胞介素1)], attachment=null, authenticateStatus=null, 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likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Wed Jun 07 07:37:56 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204742, encodeId=5953204e429e, content=厉害厉害……学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Wed May 31 08:58:58 CST 2017, time=2017-05-31, status=1, ipAttribution=), 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createdName=zhaohui6731, createdTime=Mon May 29 14:15:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203911, encodeId=acac20391122, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6XtWFkdce8Hiav6b8ntyFxhFAddYYlLh0NR1N9E3H1lYgrsbtG2lc5Z8Ht8BJh1t45TIN8fCtNbd9Pib5445babo/0, createdBy=10472062033, createdName=芳哥, createdTime=Mon May 29 08:05:55 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203839, encodeId=f0c1203839c7, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon May 29 07:06:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203701, encodeId=4e38203e015a, content=感谢分享一下!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Sun May 28 21:57:38 CST 2017, time=2017-05-28, status=1, ipAttribution=)]
    2017-05-28 laymankey

    感谢分享一下!!

    0

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