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Blood:磁共振直接血栓成像,排查深静脉血栓的新方法

2020-02-07 不详 MedSci原创

中心点:复发性同侧DVT的诊断具有挑战性,因为发生过DVT后常会存在持续的血管内异常。MRDTI阴性后的VTE复发率低,MRDTI被证实是一种可行的、可重复的诊断试验。摘要:复发性同侧深静脉血栓(DVT)的诊断具有挑战性,因为既往DVT后存在的持续血管内异常会阻碍超声诊断。磁共振直接血栓成像(MRDTI),是一项不需要静脉造影、10分钟即可完成采集的技术,已被证明可以准确区分急性复发性DVT和慢性

中心点:

复发性同侧DVT的诊断具有挑战性,因为发生过DVT后常会存在持续的血管内异常。

MRDTI阴性后的VTE复发率低,MRDTI被证实是一种可行的、可重复的诊断试验。

摘要:

复发性同侧深静脉血栓(DVT)的诊断具有挑战性,因为既往DVT后存在的持续血管内异常会阻碍超声诊断。磁共振直接血栓成像(MRDTI),是一项不需要静脉造影、10分钟即可完成采集的技术,已被证明可以准确区分急性复发性DVT和慢性血栓性残留。本研究评估了MRDTI作为排除复发性同侧DVT的唯一试验的安全性。

Theia研究是一项前瞻性的国际多中心诊断管理研究,招募临床疑诊急性复发性同侧DVT的患者(NCT02262052)。患者被纳入研究后24小时内予以MRDTI检查,并根据MRDTI检查结果进行管理。主要结果为DVT MRDTI检查阴性后3个月内的静脉血栓栓塞(VTE)发生率。次要结果是MRDTI读数的观察者间一致性。

本研究共纳入305例患者。复发性DVT的起始患病率为38%;表浅性血栓性静脉炎的诊断率为4.6%。119位MRDTI阴性的DVT和血栓性静脉炎患者(随访期间未使用任何抗凝药物)中有2位(1.7%)患者在检查后3个月内发生静脉血栓栓塞;两例均不致命。MRDTI阴性的DVT患者VTE的复发率为1.1%(95%CI 0.13-3.8%)。MRDTI图像的初始局部和事后中心读片之间的一致性非常好

综上所述,MRDTI检查阴性后的VTE复发率低,因此,MRDTI可作为一种可行的、可重复的诊断试验。

原始出处:

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    2020-11-28 xue8602
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    2020-09-26 fusion
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