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BMC Medicine:超23万人数据证实:患有精神疾病或可增加心肌梗死发生后的死亡风险

2021-03-23 MedSci原创 MedSci原创

严重的精神疾病(SMI),包括精神分裂症,躁郁症和重度抑郁症,与较高的心肌梗死(MI)死亡率相关,但冠状动脉血管重建率较低。以往的研究主要集中在精神分裂症方面,很少有资料对双相情感障碍,重度抑郁症或社

严重的精神疾病(SMI),包括精神分裂症,躁郁症和重度抑郁症,与较高的心肌梗死MI)死亡率相关,但冠状动脉血管重建率较低。以往的研究主要集中在精神分裂症方面,很少有资料对双相情感障碍,重度抑郁症或社会人口因素与MI预后之间的关系。

近日,发表在BMC Medicine杂志的一项研究表明,与没有患严重精神疾病的人相比,患严重精神疾病的人更容易在心肌梗死发生后死亡。

研究人员进行了一项全国性回顾性队列研究,收纳了来自1991年至2014年在苏格兰因心肌梗死而住院的235310名成年人,并通过入院记录收集了患者的精神分裂症,躁郁症和重度抑郁的既往史。比较了患有精神分裂症、重度抑郁症或双相情感障碍的心脏病患者与没有精神疾病史的患者的死亡和进一步心脏病发作和中风的风险。

结果发现,精神分裂症923例(0.4%),双相情感障碍642例(0.3%),重度抑郁症6239例(2.7%)。SMI30天,1年和5年较高的死亡率以及进一步发生MI和中风的风险相关。精神分裂症(OR 1.9595CI 1.64-2.30),躁郁症(OR 1.5395CI 1.26-1.86)和重度抑郁症(OR 1.3195CI 1.23-1.40)在30天后死亡率更高,精神分裂症患者死亡可能增加2倍,躁郁症或重度抑郁症患者的死亡风险增加了30%-50%

研究进一步发现,精神分裂症(HR 0.5795CI 0.48-0.67),双相情感障碍(HR 0.6995CI 0.56-0.85)和严重抑郁症(HR 0.7895CI 0.73-0.83)的患者血运重建率较低。从1991年到2014年,死亡率和血管重建差异持续存在,发生在70岁左右的MI绝对死亡率差异更为明显。而且,重度抑郁症的女性比重度抑郁症的男性在血管再通方面的减少幅度更大。

研究人员指出,这些发现可能是由于多种原因造成的,包括基础健康状况不佳、社会排斥和长期治疗方面可能存在的差异。研究小组建议,有心理健康状况的人如果对自己的健康有任何担忧,应该继续寻求医疗团队的建议。

原始出处

Kelly Fleetwood et al. Severe mental illness and mortality and coronary revascularisation following a myocardial infarction: a retrospective cohort study, BMC Medicine (2021). DOI: 10.1186/s12916-021-01937-2

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    2022-02-24 jeanqiuqiu
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    2021-07-01 kalseyzl
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    2021-03-23 病毒猎手

    #精神疾病#或可增加#心肌梗死#发生后的死亡风险

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