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CMAJ:2型糖尿病:糖、果糖和蔗糖之间的相关性

2017-07-07 何娜 吴星 环球医学

几项高质量系统评价和荟萃分析已经评估了含糖饮料与2型糖尿病之间的相关性。2017年5月,发表在《CMAJ》的一项前瞻性研究的系统评价和荟萃分析,考察了糖、果糖和蔗糖与2型糖尿病之间的相关性。

几项高质量系统评价和荟萃分析已经评估了含糖饮料与2型糖尿病之间的相关性。2017年5月,发表在《CMAJ》的一项前瞻性研究的系统评价和荟萃分析,考察了糖、果糖和蔗糖与2型糖尿病之间的相关性。

背景:含糖饮料与2型糖尿病相关。为了评估这种相关性是否也同样适用于含果糖的饮料,研究者对前瞻性队列研究开展了一项系统评价和荟萃分析。

方法:研究者检索了MEDLINE、Embase、CINAHL和Cochrane Library(直至2016年6月)。纳入评价含果糖的糖类与2型糖尿病之间相关性的前瞻性队列研究。两名独立的评价者提取相关数据并评价偏倚风险。研究者使用随机效果荟萃分析,合并了风险比(RRs)。使用推荐评估评价、发展和评估分级(GRADE)系统,评价证据的总质量。

结果:15项比较糖、果糖和蔗糖最高摄入量(中位137、35.2和78 g/d)与最低摄入量(中位65、9.7和25.8 g/d)的前瞻性队列研究(251261例受试者,16416例病例)符合纳入标准。尽管总糖(RR 0.91,95%置信区间[CI] 0.76~1.09)或果糖(RR 1.04,95% CI 0.84~1.29)与2型糖尿病没有相关性,但蔗糖与2型糖尿病风险降低相关(RR 0.89,95% CI 0.80~0.98)。评估的置信度受到总糖和果糖研究证据严重不一致,以及所有3种糖类合并估算的严重不精确的制约。

阐释:当前证据不允许研究者得出以下结论:与食物形式无关的含果糖的糖与2型糖尿病风险增加相关。进一步的研究可能影响这一估算。

试验注册:ClinicalTrials.gov,编号:NCT01608620。

原始出处:

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1837292, encodeId=a079183e2921b, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Mon May 21 23:35:00 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239029, encodeId=fa06239029e0, content=谢谢.学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhRvIvBCic3jbz4PVDcMREDl6iaWw7opPo99JEXWc0tmIrGaXGPP0y58DKDiajZfV2qR3qXdCgwIyhVq/0, createdBy=d71a1955931, createdName=QFXL123456, createdTime=Thu Aug 31 16:35:29 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220320, encodeId=e2db220320c3, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Jul 09 13:32:44 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575734, encodeId=4efb15e5734f0, content=<a href='/topic/show?id=ab8b8839095' target=_blank style='color:#2F92EE;'>#蔗糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88390, encryptionId=ab8b8839095, topicName=蔗糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aeb516160889, createdName=yangfl11, createdTime=Sun Jul 09 06:35:00 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219764, encodeId=66b1219e6422, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Sat Jul 08 07:08:32 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219566, encodeId=c27b219566db, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Fri Jul 07 17:29:24 CST 2017, time=2017-07-07, status=1, ipAttribution=)]
    2017-08-31 QFXL123456

    谢谢.学习了!

    0

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    2017-07-09 changjiu

    学习了,谢谢

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1837292, encodeId=a079183e2921b, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Mon May 21 23:35:00 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239029, encodeId=fa06239029e0, content=谢谢.学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhRvIvBCic3jbz4PVDcMREDl6iaWw7opPo99JEXWc0tmIrGaXGPP0y58DKDiajZfV2qR3qXdCgwIyhVq/0, createdBy=d71a1955931, createdName=QFXL123456, createdTime=Thu Aug 31 16:35:29 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220320, encodeId=e2db220320c3, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sun Jul 09 13:32:44 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575734, encodeId=4efb15e5734f0, content=<a href='/topic/show?id=ab8b8839095' target=_blank style='color:#2F92EE;'>#蔗糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88390, encryptionId=ab8b8839095, topicName=蔗糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aeb516160889, createdName=yangfl11, createdTime=Sun Jul 09 06:35:00 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219764, encodeId=66b1219e6422, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Sat Jul 08 07:08:32 CST 2017, time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219566, encodeId=c27b219566db, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Fri Jul 07 17:29:24 CST 2017, time=2017-07-07, status=1, ipAttribution=)]
    2017-07-09 yangfl11
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    2017-07-08 flyingzyx

    学习了,谢谢分享。

    0

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    2017-07-07 dhzzm

    学习了分享了

    0

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