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Int J Impot Res:勃起功能异常病人中内皮细胞特异性分子-1的重要性

2017-04-30 AlexYang MedSci原创

最近,有研究人员对勃起功能障碍(ED)病人中的血清内皮细胞特异性分子-1含量水平进行了测量,并探究了内皮细胞特异性分子-1 (Endocan) 水平与ED的关系。研究人员将20名健康人和64名男性病人作为研究群体,并分成了四组,包括严重ED(19名病人)、中度ED(24名病人)、轻度ED (21名病人)和对照组(20名健康人),并利用勃起功能国际问卷-5(IIEF-5)对所有病人的勃起功能障碍进行

最近,有研究人员对勃起功能障碍(ED)病人中的血清内皮细胞特异性分子-1含量水平进行了测量,并探究了内皮细胞特异性分子-1 (Endocan) 水平与ED的关系。

研究人员将20名健康人和64名男性病人作为研究群体,并分成了四组,包括严重ED(19名病人)、中度ED(24名病人)、轻度ED (21名病人)和对照组(20名健康人),并利用勃起功能国际问卷-5(IIEF-5)对所有病人的勃起功能障碍进行了评估。同时,研究人员对每一个参与者的身体质量指数(BMI)、空腹血糖水平、总睾丸素含量、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇以及甘油三脂和内皮细胞特异性分子-1进行了血清样检测。研究发现,在三组ED组合对照组中,年龄、BMI、胆固醇和空腹血糖水平没有差异(P>0.05)。而血清内皮细胞特异性分子-1的水平在严重、中度和轻度ED组中分别为1.076±0.5, 0.674±0.40 and 0.671±0.3 ng ml-1。这些结果表明了内皮细胞特异性分子-1在严重组血清中的水平跟其他组比较起来具有显著的差异。在对照组中,内皮细胞特异性分子-1血清水平为0.73±0.46 ng ml-1,要比中度和轻度ED组的内皮细胞特异性分子-1血清水平显著更高(P<0.05)。最后,研究人员指出,内皮细胞特异性分子-1的水平在对照组和ED组中的显著性差异可以帮助评估病原学ED的内皮细胞病理。

原始出处:

M Karabakan, A Bozkurt, S Akdemir et al. Significance of serum endothelial cell specific molecule-1 (Endocan) level in patients with erectile dysfunction: a pilot study. Int J Imopt Res. 20 April 2017. doi:10.1038/ijir.2017.19.

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    2017-09-24 mgqwxj
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    2017-11-08 habb
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    2017-05-02 风铃826

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