Diabetologia：生儿子的人妊娠期糖尿病风险更高？

2015-10-20 Mechront 译 MedSci原创

妊娠期间的糖尿病有两种情况，一种为妊娠前已确诊患糖尿病，称“糖尿病合并妊娠”；另一种为妊娠前糖代谢正常或有潜在糖耐量减退、妊娠期才出现或确诊的糖尿病，又称为“妊娠期糖尿病（GDM）”。糖尿病孕妇中80%以上为GDM，糖尿病合并妊娠者不足20%。GDM发生率世界各国报道为1%～14%，我国发生率为1%～5%，近年有明显增高趋势。最近有研究表明男性胎儿会降低孕妇胰岛β细胞功能，从而增加妊娠期糖尿病(G

妊娠期间的糖尿病有两种情况，一种为妊娠前已确诊患糖尿病，称“糖尿病合并妊娠”；另一种为妊娠前糖代谢正常或有潜在糖耐量减退、妊娠期才出现或确诊的糖尿病，又称为“妊娠期糖尿病（GDM）”。糖尿病孕妇中80%以上为GDM，糖尿病合并妊娠者不足20%。GDM发生率世界各国报道为1%～14%，我国发生率为1%～5%，近年有明显增高趋势。

最近有研究表明男性胎儿会降低孕妇胰岛β细胞功能，从而增加妊娠期糖尿病(GDM)风险。不过胎儿性别对孕妇糖代谢的影响依旧很微妙，还需要系统回顾、荟萃分析等评估该结论的稳定性，以及评估胎儿性别与孕妇GDM风险。

研究者检索了 PubMed、EMBASE（1950年1月-2015年4月）关于胎儿性别和GDM相关的观察性研究。最终将纳入文献进行数据处理，使用随机效应模型计算两者间RR。

该研究初筛出329篇文字，最终纳入了20篇，包含2,402,643名女性。合并数据后进行荟萃分析发现，与女性胎儿相比，男性胎儿会轻微增加孕妇GDM风险 (RR 1.04; 95% CI 1.02, 1.06)。敏感性分析也证实了两者间风险的稳定性(RR 1.03; 95% CI 1.01, 1.06) (I (2) = 0%, p = 0.66)。

研究结果表明，怀有男性胎儿比女性胎儿其妊娠期糖尿病风险大约高4%。因为可以推出胎儿性别对糖代谢通路有着潜在的影响。

原始出处：

Jaskolka D, Retnakaran R,et al.Sex of the baby and risk of gestational diabetes mellitus in the mother: a systematic review and meta-analysis.Diabetologia. 2015 Nov;58(11):2469-75.

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2016-08-15 ms5439512287675881

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2016-04-10 Liufeng6206

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2016-04-10 ms9608593228839890

#DIA#

116 0
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2015-10-24 nizongzan

很好玩?

168 0
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2015-10-24 nizongzan

大家真是奇思妙想

162 0
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2015-10-22 wjcjjian

#妊娠期#

68 0
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2015-10-22 shenxlcyp

#妊娠期糖尿病#

96 0
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2015-10-21 tshch

啦啦啦

235 0
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2015-10-21 tshch

额

192 0
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2015-10-21 tshch

额

153 0

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