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左上肺放线菌病一例误诊分析

2018-03-18 佚名 临床误诊误治

男,63岁。因咳嗽20余日入院。

【一般资料】

男,63岁。

【主诉】

因咳嗽20余日入院。

【现病史】

患者20余日前无明显诱因出现咳嗽,咳白色黏液痰,自觉发热(未测体温)。在当地医院就诊,行胸部CT检查示:左肺上叶病灶,纵隔多发淋巴结,部分淋巴结增大。诊断为肺部感染,经头孢菌素类抗生素(具体不详)静脉滴注1周,咳嗽好转,痰量减少,但停药后症状反复,遂入我院心胸外科。

【既往史】

既往体健。吸烟30年,每日20支,戒烟1月余。

【体格检查】

体温36.5℃,脉搏68/min,呼吸18/min,血压122/80mmHg。双肺呼吸音清,未闻及干湿性啰音。

【辅助检查】

查血常规、肝肾功能及肿瘤标志物均未见异常。痰细菌培养和痰找结核杆菌均阴性,痰涂片见鳞状上皮细胞、急慢性炎性细胞及不明菌群。胸部CT平扫及增强扫描示:左上肺可见4.6cm×2.7cm条索状高密度影,边界不光整,可见毛刺影,平扫CT值24Hu,增强扫描CT值72Hu;双侧各叶、段支气管通畅;纵隔内各组织间隙未见增大淋巴结。CT报告:左上肺病灶性质待定(肺癌?)。纤维支气管镜检查示:左肺支气管黏膜充血肿胀,余未见异常。CT引导下经皮肺穿刺活检示:肺泡间隔增宽,间质纤维组织增生伴淋巴细胞及灶性中性粒细胞浸润。

【初步诊断

根据前述检查,临床诊断不明,

【治疗】

患者拒绝行正电子发射型计算机断层扫描检查和再次肺穿刺活检,自动出院。2个月后患者因咳嗽加重、痰中带血再次入我院心胸外科。查体:生命体征平稳。左上肺呼吸音粗,未闻及干湿性啰音,余未见阳性体征。常规实验室检查及肿瘤标志物未见异常。胸部CT检查示:左上肺可见约3.5cm×3.4cm团块状实变影,形态不规整,周围可见毛刺及棘状突起,平扫CT值37Hu,增强扫描最高CT值90Hu,病灶中心可见类圆形不强化区,邻近部分细支气管闭塞,右肺门及纵隔内淋巴结增大。CT报告:左上肺病灶性质待定(肺癌?)。因患者不愿行进一步检查,应患者及家属要求,行手术探查明确病灶性质。术中见胸腔广泛粘连,肿物位于左肺尖处,质软,大小约4.0cm×3.0cm×3.0cm,行左上肺叶切除+淋巴结清扫术。术后病理检查示:肺组织及支气管中见急慢性炎性细胞浸润,伴出血、坏死、脓肿及显著纤维化,局部支气管扩张,局部空洞形成伴大量菌丝团,中央呈均质性,周围见放射状菌丝,HE染色嗜碱性,银染(+)。术后诊断:肺放线菌病。患者术后次日晚突发心房颤动,心率160~170/min,给予去乙酰毛花苷注射液0.4mg、胺碘酮注射液150mg静脉推注,后给予胺碘酮注射液60mg/h持续泵入,5h后转为窦性心律。转入我院呼吸内科,给予阿莫西林克拉维酸钾口服抗感染,14d后复查血常规、肝肾功能未见明显异常出院。出院后患者继续口服阿莫西林克拉维酸钾,随诊半年无复发。

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    2019-02-17 howi
  2. [GetPortalCommentsPageByObjectIdResponse(id=2083621, encodeId=44ad2083621ab, content=<a href='/topic/show?id=ecb05e4399a' target=_blank style='color:#2F92EE;'>#放线菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57439, encryptionId=ecb05e4399a, topicName=放线菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Feb 17 16:38:00 CST 2019, time=2019-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297566, encodeId=833d29e56611, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 19 06:22:04 CST 2018, time=2018-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297486, encodeId=0a8c29e48632, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun Mar 18 22:27:17 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297463, encodeId=4dad29e46318, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/12/6f80f6d18bfb74ecb66b6ced313da725.jpg, createdBy=61d639722, createdName=wuqianhong99, createdTime=Sun Mar 18 20:01:05 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297450, encodeId=d4cc29e45083, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Mar 18 18:57:34 CST 2018, time=2018-03-18, status=1, ipAttribution=)]
    2018-03-19 忠诚向上

    好好学习天天向上

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2083621, encodeId=44ad2083621ab, content=<a href='/topic/show?id=ecb05e4399a' target=_blank style='color:#2F92EE;'>#放线菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57439, encryptionId=ecb05e4399a, topicName=放线菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Feb 17 16:38:00 CST 2019, time=2019-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297566, encodeId=833d29e56611, content=好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 19 06:22:04 CST 2018, time=2018-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297486, encodeId=0a8c29e48632, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun Mar 18 22:27:17 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297463, encodeId=4dad29e46318, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/12/6f80f6d18bfb74ecb66b6ced313da725.jpg, createdBy=61d639722, createdName=wuqianhong99, createdTime=Sun Mar 18 20:01:05 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297450, encodeId=d4cc29e45083, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Mar 18 18:57:34 CST 2018, time=2018-03-18, status=1, ipAttribution=)]
    2018-03-18 惠映实验室

    学习了.谢谢分享.

    0

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    2018-03-18 wuqianhong99

    学习了.谢谢分享!

    0

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    2018-03-18 清风拂面

    谢谢分享学习

    0

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