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PLoS One:H2O2/NH4OH处理钛表面可更好的促进成骨增加抗菌性能

2018-05-16 MedSci MedSci原创

本研究中,研究人员采用NH4OH和H2O2混合物成功制备了两种具有新型微米/纳米层次结构,即蚀刻(E)和喷砂及蚀刻(SE)的钛表面。并与标准的喷砂酸蚀刻(SLA)表面相比,研究了MG63的细胞响应。采用扫描电子显微镜(SEM)、表面轮廓仪、X射线光电子能谱仪(XPS)和接触角仪分别评价表面形貌、粗糙度、化学性和润湿性。结果显示,E和SE表面上均形成具有10-30μm直径的微孔和数十纳米直径的纳米凹

本研究中,研究人员采用NH4OH和H2O2混合物成功制备了两种具有新型微米/纳米层次结构,即蚀刻(E)和喷砂及蚀刻(SE)的钛表面。并与标准的喷砂酸蚀刻(SLA)表面相比,研究了MG63的细胞响应。

采用扫描电子显微镜(SEM)、表面轮廓仪、X射线光电子能谱仪(XPS)和接触角仪分别评价表面形貌、粗糙度、化学性和润湿性。

结果显示,E和SE表面上均形成具有10-30μm直径的微孔和数十纳米直径的纳米凹坑的分层结构。微孔的大小非常接近成骨细胞的大小,这使它们成为成骨细胞的理想附着区。而且,这两种表面具有类似的粗糙度和优于SLA的亲水性。在E和SE表面检测到活性氧,因此可以推测其具有较好的抗菌性能。细胞实验也证实了细胞能力增强,并且实现了其增殖和成骨分化,尤其是在SE表面上。

综上所述,该研究结果表明,使用H2O2/NH4OH处理纯钛是提高种植体初始稳定性和增强骨结合的有效技术,是一种有前途的钛种植体表面处理技术。

原始出处:


Xin Yuan,  Yi Kang, et al., Micro/nano hierarchical structured titanium treated by NH4OH/H2O2 for enhancing cell response. PLoS One. 2018; 13(5): e0196366.  doi:  10.1371/journal.pone.0196366

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    2019-04-28 30397613
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    2018-05-18 zhaojie88
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    2018-05-16 131****1460

    学习了受益匪浅

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