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Stroke:限制性脑叶微出血与认知障碍相关

2016-10-04 xing.T MedSci原创

由此可见,限制性脑叶,但不是深部或幕下,脑微出血与认知功能改变有关,特别是在视空间执行功能方面。脑淀粉样血管病可能是潜在的病理改变,与脑微出血相关的认知功能损害有关。

大脑微出血的位置不同与不同的病理机制有关,如脑叶微出血与淀粉样脑血管病相关,而深部或幕下微出血与高血压血管病变相关。近日,卒中领域权威杂志《Stroke》上发表了一篇台湾学者的研究文章,旨在探讨大脑微出血和它们的位置对不同的认知功能的影响。

研究对象选自以社区为基础的衰老纵向研究,研究者评估了研究对象的认知功能,包括言语记忆、语言、视空间执行功能和言语执行功能,脑微出血通过3T敏感加权核磁共振成像评价。

研究者共分析了959个受试者(平均数年龄为62.5±8.6岁;425个[44.3%]男性),14.2%的研究对象发生脑微出血,根据出血位置,研究对象被分为两类:(1)深部或幕下(85人,占8.8%)和(2)限制性脑叶(49人,占5.1%)。


多元线性回归分析表明,限制性脑叶的微出血与整体认知功能(简易精神状态检查)和视空间执行功能缺失显著相关。研究者对年龄、性别、受教育年限、心血管危险因素、其他脑小血管疾病标志、中风和白质高信号进行调整,发现深部或幕下脑微出血与人群认知功能的变化不存在相关性。

由此可见,限制性脑叶,但不是深部或幕下的脑微出血与认知功能改变有关,特别是在视空间执行功能方面。脑淀粉样血管病可能是潜在的病理改变,与脑微出血相关的认知功能损害有关。

原始出处:

Chih-Ping Chung, et al. Strictly Lobar Cerebral Microbleeds Are Associated With Cognitive Impairment. Stroke. 2016.

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    2016-10-05 1e0d99ddm02(暂无匿称)

    分享一下!

    0

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    2016-10-05 医路开来

    谢谢分享,,

    0

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    2016-10-05 医路开来

    学习啦,,

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2032270, encodeId=231120322e074, content=<a href='/topic/show?id=34d784e77fe' target=_blank style='color:#2F92EE;'>#脑叶微出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84777, encryptionId=34d784e77fe, topicName=脑叶微出血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Sun Apr 09 07:03:00 CST 2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1674842, encodeId=3b2316e4842f9, content=<a href='/topic/show?id=60fb50501b3' target=_blank style='color:#2F92EE;'>#微出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50501, encryptionId=60fb50501b3, topicName=微出血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c7927121733, createdName=liuxiaona, createdTime=Fri Sep 01 20:03:00 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140555, encodeId=dbc6140555bd, content=分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Wed Oct 05 20:33:28 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140235, encodeId=6b1614023547, content=谢谢分享,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Wed Oct 05 00:00:13 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140234, encodeId=3e2a14023467, content=学习啦,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Wed Oct 05 00:00:08 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140233, encodeId=46bd140233b7, content=新话题,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Wed Oct 05 00:00:00 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-05 医路开来

    新话题,,

    0

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