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卵巢癌患者该不该预防性切除乳房?年龄也是一个坎

2016-03-23 MedSci MedSci原创

妇科肿瘤学会年会称,对60岁前确诊为卵巢癌的BRCA+患者,预防性乳房切除可提高生存获益,且费用在可接受范围。不过对于60岁以后才诊断卵巢癌的BRCA+患者,无论是医学还是经济上,进行乳房切除均说不过去。妇科肿瘤学会的指南推荐,所有确诊为卵巢癌的女性均应该进行基因检测,如果BRCA+,还需要告知患者可降低乳腺癌风险的选择。杜克大学医学中心产科学及妇科肿瘤学住院医师Charlotte R. Gamb

妇科肿瘤学会年会称,对60岁前确诊为卵巢癌的BRCA+患者,预防性乳房切除可提高生存获益,且费用在可接受范围。不过对于60岁以后才诊断卵巢癌的BRCA+患者,无论是医学还是经济上,进行乳房切除均说不过去。

妇科肿瘤学会的指南推荐,所有确诊为卵巢癌的女性均应该进行基因检测,如果BRCA+,还需要告知患者可降低乳腺癌风险的选择。

杜克大学医学中心产科学及妇科肿瘤学住院医师Charlotte R. Gamble和同事对BRCA+的卵巢癌患者进行了一项研究,探究预防性乳房切除 vs 乳腺筛查(MRI和钼靶)对患者生存和费用的影响。

研究数据显示,对40岁确诊为卵巢癌的BRCA1+患者,预防性乳房切除可延长8个月的生存(相比乳腺筛查),多出来的生存时间里,成本有效性比率(ICER)增加$12,298/年。

对于50岁确诊为卵巢癌的BRCA1+患者,预防性乳房切除可延长6个月的生存,ICER增加$24,255/年。

对于60岁确诊为卵巢癌的BRCA1+患者,预防性乳房切除可延长3个月的生存,ICER增加$56,881/年。

对于70岁确诊为卵巢癌的BRCA1+患者,预防性乳房切除可延长1.5个月的生存,ICER增加$143,207/年。

分别在40岁、50岁、60岁和70岁诊断为卵巢癌的BRCA2+患者,进行预防性乳房切除分别可延长7个月、5个月、3个月和2个月的生存。这类患者中,≤60岁的患者进行乳房切除具有成本有效性,但是对于70岁的患者,则不具有,其ICER增加$119,557/年。

此外,研究者发现,对40岁诊断为卵巢癌的患者进行乳房切除,多存活的日子里每年花费少于$100,000的可能性为99%。到70岁,BRCA1+患者的花费可降低24%,BRCA2+患者的花费可降低36%。

“60岁前诊断为卵巢癌的BRCA+患者,进行预防性乳房切除术可延长生存,每年的费用也在可接受范围。”Gamble和同事写道,“但是对于60岁以上的高危卵巢癌患者,无论是医学还是经济上,进行乳房切除均不划算,延长的生存时间很短很有限,但是付出的金钱却很多。”

原始出处:

Gamble CR, et al. Abstract 141. Presented at: Society of Gynecologic Oncology Annual Meeting; March 19-22, 2016; San Diego.

Mastectomy improves survival in younger, BRCA-positive women with ovarian cancer.Healio.March 22, 2016

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2034752, encodeId=0a042034e52df, content=<a href='/topic/show?id=69c910030635' target=_blank style='color:#2F92EE;'>#预防性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100306, encryptionId=69c910030635, topicName=预防性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Sun Sep 04 17:59:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128616, encodeId=7d9112861623, content=不错哦,会学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 16 11:55:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83299, encodeId=b7f6832993c, content=年龄不同治疗手段不同, beContent=null, objectType=article, channel=null, level=null, likeNumber=199, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Fri Apr 29 14:32:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76664, encodeId=c13ae666434, content=卫生经济学角度来评价了,但如果是有钱人,也宁愿用钱来换1.5个月的生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160529/IMG574AD2984A0809025.jpg, createdBy=33fb1613507, createdName=shineshinelv, createdTime=Sun Apr 10 12:26:00 CST 2016, time=2016-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74455, encodeId=9d28e44557f, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Mar 29 17:42:00 CST 2016, time=2016-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73753, encodeId=ba00e3753f1, content=仍存在很多争论哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=222, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=738d1704566, createdName=心流, createdTime=Fri Mar 25 16:07:00 CST 2016, time=2016-03-25, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2034752, encodeId=0a042034e52df, content=<a href='/topic/show?id=69c910030635' target=_blank style='color:#2F92EE;'>#预防性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100306, encryptionId=69c910030635, topicName=预防性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Sun Sep 04 17:59:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128616, encodeId=7d9112861623, content=不错哦,会学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 16 11:55:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83299, encodeId=b7f6832993c, content=年龄不同治疗手段不同, beContent=null, objectType=article, channel=null, level=null, likeNumber=199, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Fri Apr 29 14:32:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76664, encodeId=c13ae666434, content=卫生经济学角度来评价了,但如果是有钱人,也宁愿用钱来换1.5个月的生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160529/IMG574AD2984A0809025.jpg, createdBy=33fb1613507, createdName=shineshinelv, createdTime=Sun Apr 10 12:26:00 CST 2016, time=2016-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74455, encodeId=9d28e44557f, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Mar 29 17:42:00 CST 2016, time=2016-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73753, encodeId=ba00e3753f1, content=仍存在很多争论哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=222, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=738d1704566, createdName=心流, createdTime=Fri Mar 25 16:07:00 CST 2016, time=2016-03-25, status=1, ipAttribution=)]
    2016-09-16 1e10c84am36(暂无匿称)

    不错哦,会学到很多

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2034752, encodeId=0a042034e52df, content=<a href='/topic/show?id=69c910030635' target=_blank style='color:#2F92EE;'>#预防性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100306, encryptionId=69c910030635, topicName=预防性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Sun Sep 04 17:59:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128616, encodeId=7d9112861623, content=不错哦,会学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 16 11:55:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83299, encodeId=b7f6832993c, content=年龄不同治疗手段不同, beContent=null, objectType=article, channel=null, level=null, likeNumber=199, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Fri Apr 29 14:32:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76664, encodeId=c13ae666434, content=卫生经济学角度来评价了,但如果是有钱人,也宁愿用钱来换1.5个月的生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160529/IMG574AD2984A0809025.jpg, createdBy=33fb1613507, createdName=shineshinelv, createdTime=Sun Apr 10 12:26:00 CST 2016, time=2016-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74455, encodeId=9d28e44557f, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Mar 29 17:42:00 CST 2016, time=2016-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73753, encodeId=ba00e3753f1, content=仍存在很多争论哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=222, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=738d1704566, createdName=心流, createdTime=Fri Mar 25 16:07:00 CST 2016, time=2016-03-25, status=1, ipAttribution=)]
    2016-04-29 明崖

    年龄不同治疗手段不同

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2034752, encodeId=0a042034e52df, content=<a href='/topic/show?id=69c910030635' target=_blank style='color:#2F92EE;'>#预防性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100306, encryptionId=69c910030635, topicName=预防性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Sun Sep 04 17:59:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128616, encodeId=7d9112861623, content=不错哦,会学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 16 11:55:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83299, encodeId=b7f6832993c, content=年龄不同治疗手段不同, beContent=null, objectType=article, channel=null, level=null, likeNumber=199, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Fri Apr 29 14:32:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76664, encodeId=c13ae666434, content=卫生经济学角度来评价了,但如果是有钱人,也宁愿用钱来换1.5个月的生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160529/IMG574AD2984A0809025.jpg, createdBy=33fb1613507, createdName=shineshinelv, createdTime=Sun Apr 10 12:26:00 CST 2016, time=2016-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74455, encodeId=9d28e44557f, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Mar 29 17:42:00 CST 2016, time=2016-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73753, encodeId=ba00e3753f1, content=仍存在很多争论哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=222, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=738d1704566, createdName=心流, createdTime=Fri Mar 25 16:07:00 CST 2016, time=2016-03-25, status=1, ipAttribution=)]
    2016-04-10 shineshinelv

    卫生经济学角度来评价了,但如果是有钱人,也宁愿用钱来换1.5个月的生命

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2034752, encodeId=0a042034e52df, content=<a href='/topic/show?id=69c910030635' target=_blank style='color:#2F92EE;'>#预防性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100306, encryptionId=69c910030635, topicName=预防性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Sun Sep 04 17:59:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128616, encodeId=7d9112861623, content=不错哦,会学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 16 11:55:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83299, encodeId=b7f6832993c, content=年龄不同治疗手段不同, beContent=null, objectType=article, channel=null, level=null, likeNumber=199, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Fri Apr 29 14:32:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76664, encodeId=c13ae666434, content=卫生经济学角度来评价了,但如果是有钱人,也宁愿用钱来换1.5个月的生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160529/IMG574AD2984A0809025.jpg, createdBy=33fb1613507, createdName=shineshinelv, createdTime=Sun Apr 10 12:26:00 CST 2016, time=2016-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74455, encodeId=9d28e44557f, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Mar 29 17:42:00 CST 2016, time=2016-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73753, encodeId=ba00e3753f1, content=仍存在很多争论哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=222, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=738d1704566, createdName=心流, createdTime=Fri Mar 25 16:07:00 CST 2016, time=2016-03-25, status=1, ipAttribution=)]
    2016-03-29 忠诚向上

    好好学习一下

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2034752, encodeId=0a042034e52df, content=<a href='/topic/show?id=69c910030635' target=_blank style='color:#2F92EE;'>#预防性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100306, encryptionId=69c910030635, topicName=预防性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Sun Sep 04 17:59:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128616, encodeId=7d9112861623, content=不错哦,会学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 16 11:55:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83299, encodeId=b7f6832993c, content=年龄不同治疗手段不同, beContent=null, objectType=article, channel=null, level=null, likeNumber=199, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Fri Apr 29 14:32:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=76664, encodeId=c13ae666434, content=卫生经济学角度来评价了,但如果是有钱人,也宁愿用钱来换1.5个月的生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160529/IMG574AD2984A0809025.jpg, createdBy=33fb1613507, createdName=shineshinelv, createdTime=Sun Apr 10 12:26:00 CST 2016, time=2016-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=74455, encodeId=9d28e44557f, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Mar 29 17:42:00 CST 2016, time=2016-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=73753, encodeId=ba00e3753f1, content=仍存在很多争论哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=222, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=738d1704566, createdName=心流, createdTime=Fri Mar 25 16:07:00 CST 2016, time=2016-03-25, status=1, ipAttribution=)]
    2016-03-25 心流

    仍存在很多争论哦

    0

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