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Clinica Chimica Acta：一项关于人类慢性心力衰竭循环白细胞介素-20水平表达和预测结果的单中心观察研究结果

2020-08-10 MedSci原创 MedSci原创

白细胞介素-20水平；表达
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白细胞介素-20 (IL-20)与动脉粥样硬化等心血管疾病密切相关。然而关于IL-20表达在人慢性心力衰竭(CHF)中的相关性尚不清楚。

白细胞介素-20 (IL-20)与动脉粥样硬化等心血管疾病密切相关。然而关于IL-20表达在人慢性心力衰竭(CHF)中的相关性尚不清楚。因此，研究人员对CHF患者循环中IL-20的水平进行了研究，并观察其与CHF结局的关系。

研究人员对CHF患者进行了队列研究，收集180例CHF患者和167例对照组血样，测定每位患者血浆IL-20水平。此外，对CHF患者心血管事件的终点进行前瞻性评估。CHF患者最大随访时间为24个月，中位随访时间为21个月。

CHF患者的IL-20水平较高，在纽约心脏协会(NYHA)功能性评级II类、NYHA III和NYHA IV组中逐渐升高。根据IL-20的低、中、高tertiles将CHF患者分别分为1、2、3组。多因素Cox危险分析显示，校正混杂因素后，3组心脏事件发病率明显高于其他两组。根据血浆IL-20水平将CHF患者分为两组，IL-20水平较高的组心血管事件发生率较高。

研究结果表明，慢性心力衰竭患者循环IL-20水平显著升高，较高的IL-20水平提示慢性心力衰竭患者预后较差。

原始出处：

Yingying Zhao，Zicong Yang，A single-center observational study on the expression of circulating interleukin-20 levels and predicting outcomes in human chronic heart failure: A 2-year follow-up cohort study: Higher IL-20 levels suggest poorer outcomes in CHF

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    2021-06-02 windight

    #CTA#

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    2021-02-16 644982816_68283321

    #白细胞介素-2#

    0

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    2021-07-16 仁医06

    #研究结果#

    0

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    2021-01-28 ms7258648636991762

    #观察研究#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1850028, encodeId=d80618500288d, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Jun 02 00:58:15 CST 2021, time=2021-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800112, encodeId=4f681800112ee, content=<a href='/topic/show?id=2762e172079' target=_blank style='color:#2F92EE;'>#白细胞介素-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71720, encryptionId=2762e172079, topicName=白细胞介素-2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3dd32500118, createdName=644982816_68283321, createdTime=Tue Feb 16 06:58:15 CST 2021, time=2021-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739549, encodeId=77a11e3954924, content=<a href='/topic/show?id=8041e343504' target=_blank style='color:#2F92EE;'>#研究结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73435, encryptionId=8041e343504, topicName=研究结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Jul 16 23:58:15 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688983, encodeId=760516889834c, content=<a href='/topic/show?id=b65f90588b8' target=_blank style='color:#2F92EE;'>#观察研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90588, encryptionId=b65f90588b8, topicName=观察研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e4fa28698173, createdName=ms7258648636991762, createdTime=Thu Jan 28 00:58:15 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251815, encodeId=9bf41251815fb, content=<a href='/topic/show?id=ac5d5351ea8' target=_blank style='color:#2F92EE;'>#慢性心力衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53517, encryptionId=ac5d5351ea8, topicName=慢性心力衰竭)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Tue Aug 11 04:58:15 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620603, encodeId=cb7416206031b, content=<a href='/topic/show?id=25a4e1714f0' target=_blank style='color:#2F92EE;'>#白细胞介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71714, encryptionId=25a4e1714f0, topicName=白细胞介素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1dc20143475, createdName=yxch43, createdTime=Tue Aug 11 04:58:15 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807306, encodeId=58a180e30682, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/9484c971e5f44f9eaff769f5ce71ddcf/814572c1f5654774a44e07ea1a22187d.jpg, createdBy=63e35409263, createdName=ms美霖, createdTime=Mon Aug 10 17:44:40 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807254, encodeId=69e380e2541d, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6d095409783, createdName=ms5000002046462755, createdTime=Mon Aug 10 11:54:18 CST 2020, time=2020-08-10, status=1, ipAttribution=)]
    2020-08-11 bioon1

    #慢性心力衰竭#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1850028, encodeId=d80618500288d, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Jun 02 00:58:15 CST 2021, time=2021-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800112, encodeId=4f681800112ee, content=<a href='/topic/show?id=2762e172079' target=_blank style='color:#2F92EE;'>#白细胞介素-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71720, encryptionId=2762e172079, topicName=白细胞介素-2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3dd32500118, createdName=644982816_68283321, createdTime=Tue Feb 16 06:58:15 CST 2021, time=2021-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739549, encodeId=77a11e3954924, content=<a href='/topic/show?id=8041e343504' target=_blank style='color:#2F92EE;'>#研究结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73435, encryptionId=8041e343504, topicName=研究结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Jul 16 23:58:15 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688983, encodeId=760516889834c, content=<a href='/topic/show?id=b65f90588b8' target=_blank style='color:#2F92EE;'>#观察研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90588, encryptionId=b65f90588b8, topicName=观察研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e4fa28698173, createdName=ms7258648636991762, createdTime=Thu Jan 28 00:58:15 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251815, encodeId=9bf41251815fb, content=<a href='/topic/show?id=ac5d5351ea8' target=_blank style='color:#2F92EE;'>#慢性心力衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53517, encryptionId=ac5d5351ea8, topicName=慢性心力衰竭)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Tue Aug 11 04:58:15 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620603, encodeId=cb7416206031b, content=<a href='/topic/show?id=25a4e1714f0' target=_blank style='color:#2F92EE;'>#白细胞介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71714, encryptionId=25a4e1714f0, topicName=白细胞介素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1dc20143475, createdName=yxch43, createdTime=Tue Aug 11 04:58:15 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807306, encodeId=58a180e30682, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/9484c971e5f44f9eaff769f5ce71ddcf/814572c1f5654774a44e07ea1a22187d.jpg, createdBy=63e35409263, createdName=ms美霖, createdTime=Mon Aug 10 17:44:40 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807254, encodeId=69e380e2541d, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6d095409783, createdName=ms5000002046462755, createdTime=Mon Aug 10 11:54:18 CST 2020, time=2020-08-10, status=1, ipAttribution=)]
    2020-08-11 yxch43

    #白细胞介素#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1850028, encodeId=d80618500288d, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Jun 02 00:58:15 CST 2021, time=2021-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800112, encodeId=4f681800112ee, content=<a href='/topic/show?id=2762e172079' target=_blank style='color:#2F92EE;'>#白细胞介素-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71720, encryptionId=2762e172079, topicName=白细胞介素-2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3dd32500118, createdName=644982816_68283321, createdTime=Tue Feb 16 06:58:15 CST 2021, time=2021-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739549, encodeId=77a11e3954924, content=<a href='/topic/show?id=8041e343504' target=_blank style='color:#2F92EE;'>#研究结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73435, encryptionId=8041e343504, topicName=研究结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Jul 16 23:58:15 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688983, encodeId=760516889834c, content=<a href='/topic/show?id=b65f90588b8' target=_blank style='color:#2F92EE;'>#观察研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90588, encryptionId=b65f90588b8, topicName=观察研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e4fa28698173, createdName=ms7258648636991762, createdTime=Thu Jan 28 00:58:15 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251815, encodeId=9bf41251815fb, content=<a href='/topic/show?id=ac5d5351ea8' target=_blank style='color:#2F92EE;'>#慢性心力衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53517, encryptionId=ac5d5351ea8, topicName=慢性心力衰竭)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Tue Aug 11 04:58:15 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620603, encodeId=cb7416206031b, content=<a href='/topic/show?id=25a4e1714f0' target=_blank style='color:#2F92EE;'>#白细胞介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71714, encryptionId=25a4e1714f0, topicName=白细胞介素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1dc20143475, createdName=yxch43, createdTime=Tue Aug 11 04:58:15 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807306, encodeId=58a180e30682, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/9484c971e5f44f9eaff769f5ce71ddcf/814572c1f5654774a44e07ea1a22187d.jpg, createdBy=63e35409263, createdName=ms美霖, createdTime=Mon Aug 10 17:44:40 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807254, encodeId=69e380e2541d, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6d095409783, createdName=ms5000002046462755, createdTime=Mon Aug 10 11:54:18 CST 2020, time=2020-08-10, status=1, ipAttribution=)]
    2020-08-10 ms美霖

    谢谢

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1850028, encodeId=d80618500288d, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Jun 02 00:58:15 CST 2021, time=2021-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800112, encodeId=4f681800112ee, content=<a href='/topic/show?id=2762e172079' target=_blank style='color:#2F92EE;'>#白细胞介素-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71720, encryptionId=2762e172079, topicName=白细胞介素-2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3dd32500118, createdName=644982816_68283321, createdTime=Tue Feb 16 06:58:15 CST 2021, time=2021-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739549, encodeId=77a11e3954924, content=<a href='/topic/show?id=8041e343504' target=_blank style='color:#2F92EE;'>#研究结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73435, encryptionId=8041e343504, topicName=研究结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Fri Jul 16 23:58:15 CST 2021, time=2021-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688983, encodeId=760516889834c, content=<a href='/topic/show?id=b65f90588b8' target=_blank style='color:#2F92EE;'>#观察研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90588, encryptionId=b65f90588b8, topicName=观察研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e4fa28698173, createdName=ms7258648636991762, createdTime=Thu Jan 28 00:58:15 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251815, encodeId=9bf41251815fb, content=<a href='/topic/show?id=ac5d5351ea8' target=_blank style='color:#2F92EE;'>#慢性心力衰竭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53517, encryptionId=ac5d5351ea8, topicName=慢性心力衰竭)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Tue Aug 11 04:58:15 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620603, encodeId=cb7416206031b, content=<a href='/topic/show?id=25a4e1714f0' target=_blank style='color:#2F92EE;'>#白细胞介素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71714, encryptionId=25a4e1714f0, topicName=白细胞介素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1dc20143475, createdName=yxch43, createdTime=Tue Aug 11 04:58:15 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807306, encodeId=58a180e30682, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200807/9484c971e5f44f9eaff769f5ce71ddcf/814572c1f5654774a44e07ea1a22187d.jpg, createdBy=63e35409263, createdName=ms美霖, createdTime=Mon Aug 10 17:44:40 CST 2020, time=2020-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807254, encodeId=69e380e2541d, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6d095409783, createdName=ms5000002046462755, createdTime=Mon Aug 10 11:54:18 CST 2020, time=2020-08-10, status=1, ipAttribution=)]
    2020-08-10 ms5000002046462755

    受益匪浅

    0

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