BMJ Open：新肿瘤标志物miRNA-205（meta分析）

2015-01-26 MedSci MedSci原创

最新研究显示miRNA-205是一个良好的肿瘤生物标志物。然而，多项研究的结果并不一致。我们在这里做了一项meta分析来阐释miRNA-205在多种不同的人类恶性肿瘤中的预后作用。通过PubMed，EMBASE以及Web of Science在线搜索和一些其他高质量的评估，我们收纳了截止到2014年6月5号的17项符合要求的研究，共包含患者4827例。我们用I(2)数据分析评估这些研究

最新研究显示miRNA-205是一个良好的肿瘤生物标志物。然而，多项研究的结果并不一致。我们在这里做了一项meta分析来阐释miRNA-205在多种不同的人类恶性肿瘤中的预后作用。

通过PubMed，EMBASE以及Web of Science在线搜索和一些其他高质量的评估，我们收纳了截止到2014年6月5号的17项符合要求的研究，共包含患者4827例。我们用I(2)数据分析评估这些研究的差异，通过HRs(95% CIs)对患者的生存率和病情复发来研究miRNA-205的表达对多种不同恶性肿瘤的预后结果。

研究结果显示miRNA-205水平的升高与乳腺癌组整体生存率的提高显著相关（HR=0.78, 95% CI 0.67 to 0.91) ，与腺癌的无病生存期/无复发生存期也显著相关(HR=0.68, 95% CI 0.49 to 0.94).

因此，miRNA-205有希望作为预测腺癌和乳腺癌进展和复发的肿瘤标志物。由于miRNA-205功能复杂，因此，有必要进行进一步的相关研究。

原始出处

Zhang JY1, Sun MY2, Song NH1, Deng ZL3, Xue CY2, Yang J1.Prognostic role of microRNA-205 in multiple human malignant neoplasms: a meta-analysis of 17 studies.BMJ Open. 2015 Jan 22

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2015-10-20 feather89

#PE#

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2015-05-31 guojianrong

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2015-04-03 smallant2002

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2015-11-05 gaoxiaoe

#BMJ#

165 0
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2015-07-16 hukaixun

#标志物#

0 0
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2015-03-05 happypig

可以，学习了。

229 0
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2015-06-21 一闲

#MET#

138 0
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2015-01-28 Homburg

#miRNA#

148 0
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2015-01-26 223.104.5.**

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