2型糖尿病患者的胰岛炎症影响α细胞和β细胞功能

2013-07-31 复旦大学附属金山医院内分泌科张进安 cmt

2型糖尿病患者的胰岛炎症不仅影响β细胞功能和胰岛素产生，同时也影响α细胞的功能和胰高血糖素的产量。胰岛炎症在2型糖尿病患者β细胞功能的衰竭中起重要作用。研究胰岛炎如何影响内分泌细胞将有助于寻找新的治疗靶点。新近发现IL-6可以调节胰岛α细胞的胰高血糖素分泌。IL-6属于gp130受体介导的细胞因子家族。最新的研究显示2型糖尿病患者的胰岛表达高水平的IL-6家族的细胞因子。在2型糖尿病的小鼠模型

2型糖尿病患者的胰岛炎症不仅影响β细胞功能和胰岛素产生，同时也影响α细胞的功能和胰高血糖素的产量。

胰岛炎症在2型糖尿病患者β细胞功能的衰竭中起重要作用。研究胰岛炎如何影响内分泌细胞将有助于寻找新的治疗靶点。新近发现IL-6可以调节胰岛α细胞的胰高血糖素分泌。IL-6属于gp130受体介导的细胞因子家族。最新的研究显示2型糖尿病患者的胰岛表达高水平的IL-6家族的细胞因子。在2型糖尿病的小鼠模型，也发现了多个IL-6家族细胞因子的过度表达。当部分敲除小鼠胰腺α细胞上的gp130受体后，小鼠对葡萄糖的耐受性提高，或免患2型糖尿病。这主要是因为去除gp130受体的α细胞恢复了正常的功能。因此，在2型糖尿病患者通过调控α细胞的gp130受体可减少过多的胰高血糖素分泌，从而成为调控血糖的手段。

在脂代谢信号通路中，磷脂酶A促进多种具有生物活性的脂类介质的产生，而这些脂类中间产物参与了多种生物学功能包括免疫反应、炎症细胞侵润，促进了β细胞的死亡。

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言

评论区 (7)

#插入话题

插入图片

[GetPortalCommentsPageByObjectIdResponse(id=1749429, encodeId=639c1e49429b3, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon Dec 02 06:04:00 CST 2013, time=2013-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038358, encodeId=21bc2038358ed, content=<a href='/topic/show?id=d4f819161bd' target=_blank style='color:#2F92EE;'>#α细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19161, encryptionId=d4f819161bd, topicName=α细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/656F31B644588474D1C46903A7F84373/100, createdBy=4e842500199, createdName=ms24272190615788285182, createdTime=Thu Sep 12 13:04:00 CST 2013, time=2013-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972221, encodeId=c18719e222181, content=<a href='/topic/show?id=d8e319241a4' target=_blank style='color:#2F92EE;'>#β细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19241, encryptionId=d8e319241a4, topicName=β细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Fri Aug 23 13:04:00 CST 2013, time=2013-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383137, encodeId=7d75138313e10, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473731, encodeId=83c514e373197, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586769, encodeId=98671586e6949, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618822, encodeId=d93616188226f, content=<a href='/topic/show?id=007419239ca' target=_blank style='color:#2F92EE;'>#β细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19239, encryptionId=007419239ca, topicName=β细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b69919964433, createdName=ms24272190615788285182, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=)]
2013-12-02 baoya

#胰岛#

56 0
[GetPortalCommentsPageByObjectIdResponse(id=1749429, encodeId=639c1e49429b3, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon Dec 02 06:04:00 CST 2013, time=2013-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038358, encodeId=21bc2038358ed, content=<a href='/topic/show?id=d4f819161bd' target=_blank style='color:#2F92EE;'>#α细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19161, encryptionId=d4f819161bd, topicName=α细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/656F31B644588474D1C46903A7F84373/100, createdBy=4e842500199, createdName=ms24272190615788285182, createdTime=Thu Sep 12 13:04:00 CST 2013, time=2013-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972221, encodeId=c18719e222181, content=<a href='/topic/show?id=d8e319241a4' target=_blank style='color:#2F92EE;'>#β细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19241, encryptionId=d8e319241a4, topicName=β细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Fri Aug 23 13:04:00 CST 2013, time=2013-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383137, encodeId=7d75138313e10, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473731, encodeId=83c514e373197, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586769, encodeId=98671586e6949, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618822, encodeId=d93616188226f, content=<a href='/topic/show?id=007419239ca' target=_blank style='color:#2F92EE;'>#β细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19239, encryptionId=007419239ca, topicName=β细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b69919964433, createdName=ms24272190615788285182, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=)]
2013-09-12 ms24272190615788285182

#α细胞#

82 0
[GetPortalCommentsPageByObjectIdResponse(id=1749429, encodeId=639c1e49429b3, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon Dec 02 06:04:00 CST 2013, time=2013-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038358, encodeId=21bc2038358ed, content=<a href='/topic/show?id=d4f819161bd' target=_blank style='color:#2F92EE;'>#α细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19161, encryptionId=d4f819161bd, topicName=α细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/656F31B644588474D1C46903A7F84373/100, createdBy=4e842500199, createdName=ms24272190615788285182, createdTime=Thu Sep 12 13:04:00 CST 2013, time=2013-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972221, encodeId=c18719e222181, content=<a href='/topic/show?id=d8e319241a4' target=_blank style='color:#2F92EE;'>#β细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19241, encryptionId=d8e319241a4, topicName=β细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Fri Aug 23 13:04:00 CST 2013, time=2013-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383137, encodeId=7d75138313e10, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473731, encodeId=83c514e373197, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586769, encodeId=98671586e6949, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618822, encodeId=d93616188226f, content=<a href='/topic/show?id=007419239ca' target=_blank style='color:#2F92EE;'>#β细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19239, encryptionId=007419239ca, topicName=β细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b69919964433, createdName=ms24272190615788285182, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=)]
2013-08-23 paperyu

#β细胞功能#

72 0
[GetPortalCommentsPageByObjectIdResponse(id=1749429, encodeId=639c1e49429b3, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon Dec 02 06:04:00 CST 2013, time=2013-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038358, encodeId=21bc2038358ed, content=<a href='/topic/show?id=d4f819161bd' target=_blank style='color:#2F92EE;'>#α细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19161, encryptionId=d4f819161bd, topicName=α细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/656F31B644588474D1C46903A7F84373/100, createdBy=4e842500199, createdName=ms24272190615788285182, createdTime=Thu Sep 12 13:04:00 CST 2013, time=2013-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972221, encodeId=c18719e222181, content=<a href='/topic/show?id=d8e319241a4' target=_blank style='color:#2F92EE;'>#β细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19241, encryptionId=d8e319241a4, topicName=β细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Fri Aug 23 13:04:00 CST 2013, time=2013-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383137, encodeId=7d75138313e10, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473731, encodeId=83c514e373197, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586769, encodeId=98671586e6949, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618822, encodeId=d93616188226f, content=<a href='/topic/show?id=007419239ca' target=_blank style='color:#2F92EE;'>#β细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19239, encryptionId=007419239ca, topicName=β细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b69919964433, createdName=ms24272190615788285182, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=)]
2013-08-02 aids213

#2型糖尿病患者#

64 0
[GetPortalCommentsPageByObjectIdResponse(id=1749429, encodeId=639c1e49429b3, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon Dec 02 06:04:00 CST 2013, time=2013-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038358, encodeId=21bc2038358ed, content=<a href='/topic/show?id=d4f819161bd' target=_blank style='color:#2F92EE;'>#α细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19161, encryptionId=d4f819161bd, topicName=α细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/656F31B644588474D1C46903A7F84373/100, createdBy=4e842500199, createdName=ms24272190615788285182, createdTime=Thu Sep 12 13:04:00 CST 2013, time=2013-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972221, encodeId=c18719e222181, content=<a href='/topic/show?id=d8e319241a4' target=_blank style='color:#2F92EE;'>#β细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19241, encryptionId=d8e319241a4, topicName=β细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Fri Aug 23 13:04:00 CST 2013, time=2013-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383137, encodeId=7d75138313e10, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473731, encodeId=83c514e373197, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586769, encodeId=98671586e6949, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618822, encodeId=d93616188226f, content=<a href='/topic/show?id=007419239ca' target=_blank style='color:#2F92EE;'>#β细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19239, encryptionId=007419239ca, topicName=β细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b69919964433, createdName=ms24272190615788285182, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=)]
2013-08-02 xue8604

#糖尿病患者#

62 0
[GetPortalCommentsPageByObjectIdResponse(id=1749429, encodeId=639c1e49429b3, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon Dec 02 06:04:00 CST 2013, time=2013-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038358, encodeId=21bc2038358ed, content=<a href='/topic/show?id=d4f819161bd' target=_blank style='color:#2F92EE;'>#α细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19161, encryptionId=d4f819161bd, topicName=α细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/656F31B644588474D1C46903A7F84373/100, createdBy=4e842500199, createdName=ms24272190615788285182, createdTime=Thu Sep 12 13:04:00 CST 2013, time=2013-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972221, encodeId=c18719e222181, content=<a href='/topic/show?id=d8e319241a4' target=_blank style='color:#2F92EE;'>#β细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19241, encryptionId=d8e319241a4, topicName=β细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Fri Aug 23 13:04:00 CST 2013, time=2013-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383137, encodeId=7d75138313e10, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473731, encodeId=83c514e373197, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586769, encodeId=98671586e6949, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618822, encodeId=d93616188226f, content=<a href='/topic/show?id=007419239ca' target=_blank style='color:#2F92EE;'>#β细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19239, encryptionId=007419239ca, topicName=β细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b69919964433, createdName=ms24272190615788285182, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=)]
2013-08-02 般若傻瓜

#细胞功能#

62 0
[GetPortalCommentsPageByObjectIdResponse(id=1749429, encodeId=639c1e49429b3, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Mon Dec 02 06:04:00 CST 2013, time=2013-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038358, encodeId=21bc2038358ed, content=<a href='/topic/show?id=d4f819161bd' target=_blank style='color:#2F92EE;'>#α细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19161, encryptionId=d4f819161bd, topicName=α细胞)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/656F31B644588474D1C46903A7F84373/100, createdBy=4e842500199, createdName=ms24272190615788285182, createdTime=Thu Sep 12 13:04:00 CST 2013, time=2013-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972221, encodeId=c18719e222181, content=<a href='/topic/show?id=d8e319241a4' target=_blank style='color:#2F92EE;'>#β细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19241, encryptionId=d8e319241a4, topicName=β细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Fri Aug 23 13:04:00 CST 2013, time=2013-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383137, encodeId=7d75138313e10, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473731, encodeId=83c514e373197, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586769, encodeId=98671586e6949, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618822, encodeId=d93616188226f, content=<a href='/topic/show?id=007419239ca' target=_blank style='color:#2F92EE;'>#β细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19239, encryptionId=007419239ca, topicName=β细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b69919964433, createdName=ms24272190615788285182, createdTime=Fri Aug 02 05:04:00 CST 2013, time=2013-08-02, status=1, ipAttribution=)]
2013-08-02 ms24272190615788285182

#β细胞#

69 0

内科

外科

专科科室

热点

按科室浏览

临床工具

科研工具

其他工具

科研数智化

真实世界研究解决方案

数字化学术传播解决方案

其它

内分泌科

2型糖尿病患者的胰岛炎症影响α细胞和β细胞功能

相关资讯

科室

工具

服务