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BMC Med:阿尔茨海默氏病患者对热和疼痛感觉迟钝?

2016-08-11 Seven L 译 MedSci原创

目的:与健康对照组相比,阿尔茨海默氏病(AD)患者使用更少的止痛药,报道疼痛的频率也更低。这些结果是否反映出AD患者对疼痛的感知减少或无法交流疼痛仍是未知的。方法:为了探究AD患者疼痛相关问题,研究者进行了一项横断面研究,纳入了40名≥65岁的AD患者,其中女性20名,中位数年龄75岁;按性别匹配40名对照组,中位数年龄70岁;比较两组之间对温暖、轻微疼痛、中度疼痛的接触诱发感性热阈的心理生理反应

目的:与健康对照组相比,阿尔茨海默氏病(AD)患者使用更少的止痛药,报道疼痛的频率也更低。这些结果是否反映出AD患者对疼痛的感知减少或无法交流疼痛仍是未知的。

方法:为了探究AD患者疼痛相关问题,研究者进行了一项横断面研究,纳入了40名≥65岁的AD患者,其中女性20名,中位数年龄75岁;按性别匹配40名对照组,中位数年龄70岁;比较两组之间对温暖、轻微疼痛、中度疼痛的接触诱发感性热阈的心理生理反应,以及自我报道每一个知觉的不愉快情况。

结果:与对照组相比,AD组需要更高的阈值才报道感知到了温暖(Cohen's d = 0.64, p = 0.002)、轻微疼痛(Cohen's d = 0.51, p = 0.016)和中度疼痛(Cohen's d = 0.45, p = 0.043)。在对不愉快知觉的评级上,两组之间没有显著差异(p > 0.05)。

结论:与对照组相比,AD患者对热和疼痛的感觉不太敏感,但是情感方面不愉快的表现没有差异。所以AD患者在报道疼痛或经理组织器官损伤时,其程度可能已经超过了我们平时的一般认知;这些结果也可以解释为什么AD患者报道疼痛更少,需要止疼药更少。

原始出处:

Monroe TB.et al.Contact heat sensitivity and reports of unpleasantness in communicative people with mild to moderate cognitive impairment in Alzheimer's disease: a cross-sectional study.BMC Med. 2016 May 10;14:74. doi: 10.1186/s12916-016-0619-1.


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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99040, encodeId=283b99040aa, content=早期识别很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:15:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365165, encodeId=cc40136516506, content=<a href='/topic/show?id=f2049e785f1' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97785, encryptionId=f2049e785f1, topicName=阿尔茨海默氏病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743b215, createdName=fusion, createdTime=Sat Aug 13 06:11:00 CST 2016, time=2016-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470085, encodeId=2d5914e008532, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sat Aug 13 06:11:00 CST 2016, time=2016-08-13, status=1, ipAttribution=)]
    2016-10-09 ylzr123

    赞一个!好文章拜读了,认真学习了。

    0

  5. 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  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99040, encodeId=283b99040aa, content=早期识别很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:15:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365165, encodeId=cc40136516506, content=<a href='/topic/show?id=f2049e785f1' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97785, encryptionId=f2049e785f1, topicName=阿尔茨海默氏病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743b215, createdName=fusion, createdTime=Sat Aug 13 06:11:00 CST 2016, time=2016-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470085, encodeId=2d5914e008532, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sat Aug 13 06:11:00 CST 2016, time=2016-08-13, status=1, ipAttribution=)]
    2016-09-03 李东泽

    很好,不错,以后会多学习

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Oct 09 06:58:06 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816708, encodeId=44681816e08b4, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Jun 28 03:11:00 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99040, encodeId=283b99040aa, content=早期识别很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:15:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365165, encodeId=cc40136516506, content=<a href='/topic/show?id=f2049e785f1' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97785, encryptionId=f2049e785f1, topicName=阿尔茨海默氏病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743b215, createdName=fusion, createdTime=Sat Aug 13 06:11:00 CST 2016, time=2016-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470085, encodeId=2d5914e008532, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sat Aug 13 06:11:00 CST 2016, time=2016-08-13, status=1, ipAttribution=)]
    2016-08-16 cgessmu

    哦,不错啊

    0

  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=99040, encodeId=283b99040aa, content=早期识别很重要!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLJ7BzcCPMKqjxDXnZ6zibwCZgJtpSexqXgmj8tQpWllJzNGgJoQQG7KcQLXhJ6MXnpHx3srW1jXf6/0, createdBy=8d1836681, createdName=huiminghappy, createdTime=Tue Aug 16 07:15:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1365165, encodeId=cc40136516506, content=<a href='/topic/show?id=f2049e785f1' target=_blank style='color:#2F92EE;'>#阿尔茨海默氏病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97785, encryptionId=f2049e785f1, topicName=阿尔茨海默氏病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=743b215, createdName=fusion, createdTime=Sat Aug 13 06:11:00 CST 2016, time=2016-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470085, encodeId=2d5914e008532, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sat Aug 13 06:11:00 CST 2016, time=2016-08-13, status=1, ipAttribution=)]
    2016-08-16 huiminghappy

    早期识别很重要!

    0

  9. 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  10. 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