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Gastric Cancer:血清ANOS1水平可作为胃癌的诊断生物标志物

2019-09-08 不详 MedSci原创

发现特异性的血清生物标志物可能会改善胃癌患者(GC)的治疗效果。有研究已经确定了候选血清标志物,anosmin 1(ANOS1),二氢嘧啶酶样3(DPYSL3)和黑色素瘤相关抗原D2(MAGE-D2),并通过单中心回顾性分析评估了它们的临床意义。在这里,研究人员进行了一项前瞻性多中心观察研究,旨在验证这些潜在标志物的诊断性能。

背景
发现特异性的血清生物标志物可能会改善癌患者(GC)的治疗效果。有研究已经确定了候选血清标志物,anosmin 1(ANOS1),二氢嘧啶酶样3(DPYSL3)和黑色素瘤相关抗原D2(MAGE-D2),并通过单中心回顾性分析评估了它们的临床意义。在这里,研究人员进行了一项前瞻性多中心观察研究,旨在验证这些潜在标志物的诊断性能。

方法
研究人员分析了GC和健康志愿者患者手术前后三种潜在生物标志物的血清水平。使用ELISA进行血清和GC组织水平的定量。

结果
对于ANOS1,DPYSL3和MAGED2,区分患有GC的患者与健康对照的曲线下面积(AUC)值分别为0.7058,0.6188和0.5031。ANOS1测定的灵敏度和特异性分别为0.36和0.85。从健康对照中区分患有I期GC的患者的ANOS1的AUC值是0.7131。I期GC患者血清ANOS1水平显着高于健康对照组(中位数分别为1179 ng/ml和461ng/ml,P<0.0001),并且在切除原发性GC病灶后降低(P<0.0001)。血清ANOS1和DPYSL3水平的组合增加了区分具有GC的患者与健康对照的AUC值。ANOS1的血清水平与癌胚抗原,碳水化合物抗原19-9或其他炎症标志物的血清水平无显着相关性。

结论
血清ANOS1水平可作为诊断GC的有用血清标志物。

原始出处:

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    2020-07-24 skhzy
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    2020-07-03 许安
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  8. [GetPortalCommentsPageByObjectIdResponse(id=1893644, encodeId=e188189364431, content=<a href='/topic/show?id=4fc4e85161' target=_blank style='color:#2F92EE;'>#gastric#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7851, encryptionId=4fc4e85161, topicName=gastric)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b30126, createdName=skhzy, createdTime=Fri Jul 24 22:14:00 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712089, encodeId=bee11e1208905, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Apr 11 13:14:00 CST 2020, time=2020-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2058987, encodeId=9461205898eaf, content=<a href='/topic/show?id=e9f38324118' target=_blank style='color:#2F92EE;'>#胃癌的诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83241, encryptionId=e9f38324118, topicName=胃癌的诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Sat Jan 11 19:14:00 CST 2020, time=2020-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841429, encodeId=4fcf184142951, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sun May 03 23:14:00 CST 2020, time=2020-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072695, encodeId=1c0620e269568, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Jul 03 08:14:00 CST 2020, time=2020-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560850, encodeId=650e1560850b1, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Sep 10 01:14:00 CST 2019, time=2019-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566859, encodeId=9a601566859a9, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Sep 10 01:14:00 CST 2019, time=2019-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=372476, encodeId=a6bb3e247610, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Mon Sep 09 06:43:46 CST 2019, time=2019-09-09, status=1, ipAttribution=)]
    2019-09-09 thm112988

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