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CELL:LC3相关的吞噬作用促进肿瘤免疫耐受

2018-09-26 海北 MedSci原创

靶向癌细胞和肿瘤微环境中的自噬是癌症治疗的当前目标。然而,规范自噬的组成部分在其他生物过程中也能够发挥作用,这增加了该目标的复杂性。

靶向癌细胞和肿瘤微环境中的自噬是癌症治疗的当前目标。然而,规范自噬的组成部分在其他生物过程中也能够发挥作用,这增加了该目标的复杂性。
自噬蛋白的一种替代功能是LC3相关的吞噬作用(LAP),其在吞噬体成熟和随后的信号传导事件中起作用。最近,来自圣犹达儿童研究医院的研究人员发现,骨髓区室中LAP的损伤,而不是典型的自噬,在死亡的肿瘤细胞的吞噬作用下诱导肿瘤相关巨噬细胞(TAM)对肿瘤生长的控制。
单细胞RNA测序(RNA-seq)分析显示,LAP缺陷诱导促炎基因表达,并触发TAM中STING介导的I型干扰素应答。研究人员还发现,LAP损伤的抗肿瘤作用需要肿瘤浸润性T细胞,这取决于STING和I型干扰素反应。
因此,肿瘤微环境的髓样细胞中的自噬蛋白通过影响LAP,帮助T淋巴细胞的免疫抑制。

原始出处:
Cunha LD et al. LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance. CELL 2018, DOI: 10.1016/j.cell.2018.08.061.

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    2019-09-11 维他命
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    2018-10-02 kafei

    学习了谢谢

    0

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    2018-09-26 明月清辉

    谢谢分享,学习了

    0

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    2018-09-26 lietome24

    认真学习,不断进步,把经验分享给同好。点赞了!

    0

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    2018-09-26 183****7028

    学习

    0

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