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JCEM:1型糖尿病患者非酒精性脂肪性肝病患病率

2020-08-24 MedSci原创 MedSci原创

1型糖尿病患者NAFLD的患病率很高,并且高度依赖于所用的诊断方法和NAFLD定义。

非酒精性脂肪肝疾病(NAFLD)的患病率很高,尤其是在肥胖症和2型糖尿病患者中,预计在未来几十年会急剧上升。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在评估1型糖尿病患者NAFLD患病率,并探讨了相关的特征和结局。

研究人员检索了PubMed和Embase数据库中2020年3月前发表关于NAFLD和1型糖尿病的研究,并筛选了纳入文献的参考文献。两位研究者独立筛选了标题/摘要。一位研究人员筛选了全文文章。NAFLD的定义如个别研究所述,即脂肪变性和/或纤维化。排除了未报告肝脂肪变性替代病因或仅将NAFLD定义为肝酶升高的研究。最初,919篇文献符合选择标准。一位研究人员使用标准化表格进行了数据提取和偏差评估风险。

研究人员通过使用随机效应模型的荟萃分析评估合并患病率,随后通过亚组分析、荟萃回归分析和敏感性分析探索异质性。该分析纳入了2009年至2019年期间发表的20项研究(n=3901)。合并的NAFLD患病率为19.3%(95%CI为12.3-27.5%),在成人增加到22.0%(95%CI为13.9-31.2%)。与使用磁共振成像(8.6%,95%CI为2.1-18.6%)、肝活检(19.3%,95%CI为10.0-30.7%)或瞬时弹性成像检查(2.3%,95%CI为0.6-4.8%)的研究相比,超声检查的NAFLD合并患病率高(27.1%,95%CI为18.7-36.3%)。

由此可见,1型糖尿病患者NAFLD的患病率很高,并且高度依赖于所用的诊断方法和NAFLD定义。

原始出处:

Eva Maria Brandtner,et al.Prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with type 1 diabetes mellitus: a systematic review and meta-analysis.JCEM.2020.https://doi.org/10.1210/clinem/dgaa575

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    2021-01-09 qjddjq
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    2021-06-19 smallant2015
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1810184, encodeId=cfd118101844e, content=<a href='/topic/show?id=70f484349b5' target=_blank style='color:#2F92EE;'>#脂肪性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84349, encryptionId=70f484349b5, topicName=脂肪性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Sat Jan 09 05:05:21 CST 2021, time=2021-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777975, encodeId=c6c31e7797574, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, 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  6. 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level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Fri Apr 23 04:05:21 CST 2021, time=2021-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673607, encodeId=b95016e36079a, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Fri Jul 02 13:05:21 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814163, encodeId=4710814163b5, content=标记一下 学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ce05381686, createdName=ms4000002082197205, createdTime=Thu Aug 27 17:47:28 CST 2020, time=2020-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250708, encodeId=f2151250e08aa, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Wed Aug 26 03:05:21 CST 2020, time=2020-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474975, encodeId=08b714e4975c5, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Aug 26 03:05:21 CST 2020, time=2020-08-26, status=1, ipAttribution=)]
    2021-04-23 achengzhao
  7. 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  8. 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    2020-08-27 ms4000002082197205

    标记一下 学习了

    0

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