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ASCO 2014：局部晚期NSCLC每周三次紫杉醇同步放化疗（CCRT）优于每周一次

2014-05-31 Ruanancy 译 医学论坛网

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摘要号：#7545第一作者：朱广迎，北京大学肿瘤医院肿瘤放疗科标题：局部晚期非小细胞肺癌患者同步放化疗中紫杉醇每周一次用法vs.每周三次用法的一项随机化III期试验背景：由于局部晚期非小细胞肺癌（LA NSCLC）的局部复发率较高，临床上对其进行最优管理仍具有挑战性。NCCN指南推荐把同步放化疗（CCRT）作为LA NSCLC的标准疗法。本III期试验研究的目的是：对比局部晚期非小细胞肺癌患者同步

摘要号：#7545

第一作者：朱广迎，北京大学肿瘤医院肿瘤放疗科

标题：局部晚期非小细胞肺癌患者同步放化疗中紫杉醇每周一次用法vs.每周三次用法的一项随机化III期试验

背景：由于局部晚期非小细胞肺癌（LA NSCLC）的局部复发率较高，临床上对其进行最优管理仍具有挑战性。NCCN指南推荐把同步放化疗（CCRT）作为LA NSCLC的标准疗法。本III期试验研究的目的是：对比局部晚期非小细胞肺癌患者同步放化疗中紫杉醇每周一次用法（组2）与每周三次用法（组1）。

方法：在本多中心、随机化对照III期的试验中，接受诱导性化学疗法治疗2至4个周期后的LANSCLC患者被随机分配为两组。组1的化疗方案是紫杉醇（15mg/m2，3次/周，6周总剂量为270 mg/ m2）；在组2中，化疗方案是紫杉醇（45mg/m2，1次/周，6周总剂量为270 mg/ m2）的；放疗方案是60-70Gy（每次2Gy，每周5次）。

结果：2006年3月至2013年2月期间的115例患者被纳入研究。组1有63例患者，其中3例发生了3级放射性食管炎，3例发生了3级白细胞减少症，12例发生了3级放射性肺炎，1例发生了5级放射性肺炎、死于呼吸衰竭；组2有52例患者，其中5例发生了3级放射性食管炎，15例发生了3级或4级白细胞减少症，6例发生了3级放射性肺炎，2例发生了5级的放射性肺炎、死于呼吸衰竭。组1的反应率（87.3％）明显高于组2（57.7％）（P=0.023），而两组的PFS中位值分别为11.0ms和7.4ms（P =0.039）

结论：研究结果显示，LANSCLC患者CCRT中紫杉醇每周三次用法比每周一次用法更安全、有效。临床试验信息：ChiCTR-TRC-10000786。

研究链接：A randomized phase III trial comparing triple weekly usage with weekly usage of paclitaxel in concurrent chemoradiotherapy for patients with locally advanced non-small cell lung cancer. (Abstract 7545)

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    2015-04-01 yhy100208

    #局部晚期#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1650701, encodeId=74ab1650e0112, content=<a href='/topic/show?id=ffae4e614b6' target=_blank style='color:#2F92EE;'>#局部晚期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47614, encryptionId=ffae4e614b6, topicName=局部晚期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=901d24099859, createdName=yhy100208, createdTime=Wed Apr 01 10:18:00 CST 2015, time=2015-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938312, encodeId=99121938312fc, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Wed Jul 02 05:18:00 CST 2014, time=2014-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287863, encodeId=bda8128e86310, content=<a href='/topic/show?id=4d185e31825' target=_blank style='color:#2F92EE;'>#放化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57318, encryptionId=4d185e31825, topicName=放化疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=310e209, createdName=yzh399, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341460, encodeId=ffae1341460ed, content=<a href='/topic/show?id=4310528ea7' target=_blank style='color:#2F92EE;'>#CRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5287, encryptionId=4310528ea7, topicName=CRT)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405654, encodeId=4291140565405, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416255, encodeId=8c031416255a0, content=<a href='/topic/show?id=6cef59801ea' target=_blank style='color:#2F92EE;'>#晚期NSCLC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59801, encryptionId=6cef59801ea, topicName=晚期NSCLC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b093156350, createdName=经常头晕, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516663, encodeId=066715166636f, content=<a href='/topic/show?id=a8183896891' target=_blank style='color:#2F92EE;'>#同步放化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38968, encryptionId=a8183896891, topicName=同步放化疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1dd10999249, createdName=12498e0fm81暂无昵称, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=)]
    2014-07-02 quxin068

    #ASC#

    0

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    2014-06-02 yzh399

    #放化疗#

    0

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    2014-06-02 41514487@qq.com

    #CRT#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1650701, encodeId=74ab1650e0112, content=<a href='/topic/show?id=ffae4e614b6' target=_blank style='color:#2F92EE;'>#局部晚期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47614, encryptionId=ffae4e614b6, topicName=局部晚期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=901d24099859, createdName=yhy100208, createdTime=Wed Apr 01 10:18:00 CST 2015, time=2015-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938312, encodeId=99121938312fc, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Wed Jul 02 05:18:00 CST 2014, time=2014-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287863, encodeId=bda8128e86310, content=<a href='/topic/show?id=4d185e31825' target=_blank style='color:#2F92EE;'>#放化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57318, encryptionId=4d185e31825, topicName=放化疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=310e209, createdName=yzh399, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341460, encodeId=ffae1341460ed, content=<a href='/topic/show?id=4310528ea7' target=_blank style='color:#2F92EE;'>#CRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5287, encryptionId=4310528ea7, topicName=CRT)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405654, encodeId=4291140565405, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416255, encodeId=8c031416255a0, content=<a href='/topic/show?id=6cef59801ea' target=_blank style='color:#2F92EE;'>#晚期NSCLC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59801, encryptionId=6cef59801ea, topicName=晚期NSCLC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b093156350, createdName=经常头晕, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516663, encodeId=066715166636f, content=<a href='/topic/show?id=a8183896891' target=_blank style='color:#2F92EE;'>#同步放化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38968, encryptionId=a8183896891, topicName=同步放化疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1dd10999249, createdName=12498e0fm81暂无昵称, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=)]
    2014-06-02 chg122

    #局部#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1650701, encodeId=74ab1650e0112, content=<a href='/topic/show?id=ffae4e614b6' target=_blank style='color:#2F92EE;'>#局部晚期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47614, encryptionId=ffae4e614b6, topicName=局部晚期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=901d24099859, createdName=yhy100208, createdTime=Wed Apr 01 10:18:00 CST 2015, time=2015-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938312, encodeId=99121938312fc, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Wed Jul 02 05:18:00 CST 2014, time=2014-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287863, encodeId=bda8128e86310, content=<a href='/topic/show?id=4d185e31825' target=_blank style='color:#2F92EE;'>#放化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57318, encryptionId=4d185e31825, topicName=放化疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=310e209, createdName=yzh399, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341460, encodeId=ffae1341460ed, content=<a href='/topic/show?id=4310528ea7' target=_blank style='color:#2F92EE;'>#CRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5287, encryptionId=4310528ea7, topicName=CRT)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405654, encodeId=4291140565405, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416255, encodeId=8c031416255a0, content=<a href='/topic/show?id=6cef59801ea' target=_blank style='color:#2F92EE;'>#晚期NSCLC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59801, encryptionId=6cef59801ea, topicName=晚期NSCLC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b093156350, createdName=经常头晕, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516663, encodeId=066715166636f, content=<a href='/topic/show?id=a8183896891' target=_blank style='color:#2F92EE;'>#同步放化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38968, encryptionId=a8183896891, topicName=同步放化疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1dd10999249, createdName=12498e0fm81暂无昵称, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=)]
    2014-06-02 经常头晕

    #晚期NSCLC#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1650701, encodeId=74ab1650e0112, content=<a href='/topic/show?id=ffae4e614b6' target=_blank style='color:#2F92EE;'>#局部晚期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47614, encryptionId=ffae4e614b6, topicName=局部晚期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=901d24099859, createdName=yhy100208, createdTime=Wed Apr 01 10:18:00 CST 2015, time=2015-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938312, encodeId=99121938312fc, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Wed Jul 02 05:18:00 CST 2014, time=2014-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1287863, encodeId=bda8128e86310, content=<a href='/topic/show?id=4d185e31825' target=_blank style='color:#2F92EE;'>#放化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57318, encryptionId=4d185e31825, topicName=放化疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=310e209, createdName=yzh399, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341460, encodeId=ffae1341460ed, content=<a href='/topic/show?id=4310528ea7' target=_blank style='color:#2F92EE;'>#CRT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5287, encryptionId=4310528ea7, topicName=CRT)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405654, encodeId=4291140565405, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416255, encodeId=8c031416255a0, content=<a href='/topic/show?id=6cef59801ea' target=_blank style='color:#2F92EE;'>#晚期NSCLC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59801, encryptionId=6cef59801ea, topicName=晚期NSCLC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b093156350, createdName=经常头晕, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1516663, encodeId=066715166636f, content=<a href='/topic/show?id=a8183896891' target=_blank style='color:#2F92EE;'>#同步放化疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38968, encryptionId=a8183896891, topicName=同步放化疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1dd10999249, createdName=12498e0fm81暂无昵称, createdTime=Mon Jun 02 12:18:00 CST 2014, time=2014-06-02, status=1, ipAttribution=)]
    2014-06-02 12498e0fm81暂无昵称

    #同步放化疗#

    0

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